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Entries
Interleukin-15 signaling
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authored
[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
created
[InstanceEdit:8983431] Duenas, Corina, 2017-03-23
crossReference
[DatabaseIdentifier:12325400] BioModels Database:BIOMD0000000504
[DatabaseIdentifier:12325642] BioModels Database:BIOMD0000000968
[DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477
dbId
8983432
displayName
Interleukin-15 signaling
doi
10.3180/R-HSA-8983432.2
edited
[InstanceEdit:9005908] Jupe, Steve, 2017-05-11
eventOf
[Pathway:R-HSA-451927] Interleukin-2 family signaling - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:1301068] interleukin-15-mediated signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-8983307] IL15 binds IL15RA - Homo sapiens
[BlackBoxEvent:R-HSA-449115] IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 - Homo sapiens
[BlackBoxEvent:R-HSA-8983298] IL15 binds IL2RB:JAK1 and IL2RG:JAK3 - Homo sapiens
[BlackBoxEvent:R-HSA-8983300] IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 - Homo sapiens
[BlackBoxEvent:R-HSA-9009700] IL2RB and IL2RG are phosphorylated - Homo sapiens
[BlackBoxEvent:R-HSA-8983378] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 - Homo sapiens
[BlackBoxEvent:R-HSA-8983371] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 - Homo sapiens
[BlackBoxEvent:R-HSA-8983374] p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 - Homo sapiens
[BlackBoxEvent:R-HSA-8983373] p-Y-STAT3 binds p-STAT5 - Homo sapiens
[BlackBoxEvent:R-HSA-8983379] p-Y-STAT3:p-STAT5 translocates to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-8983299] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 - Homo sapiens
[BlackBoxEvent:R-HSA-8983309] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 - Homo sapiens
[Reaction:R-HSA-8983394] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 - Homo sapiens
[BlackBoxEvent:R-HSA-8983384] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 - Homo sapiens
[BlackBoxEvent:R-HSA-8983425] IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 - Homo sapiens
[BlackBoxEvent:R-HSA-8983424] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 - Homo sapiens
[BlackBoxEvent:R-HSA-8983335] IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8983265] The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines
[LiteratureReference:9011522] The emerging safety profile of JAK inhibitors in rheumatic disease
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Interleukin-15 signaling
orthologousEvent
[Pathway:R-DDI-8983432] Interleukin-15 signaling - Dictyostelium discoideum
[Pathway:R-CEL-8983432] Interleukin-15 signaling - Caenorhabditis elegans
[Pathway:R-DME-8983432] Interleukin-15 signaling - Drosophila melanogaster
[Pathway:R-GGA-8983432] Interleukin-15 signaling - Gallus gallus
[Pathway:R-XTR-8983432] Interleukin-15 signaling - Xenopus tropicalis
[Pathway:R-DRE-8983432] Interleukin-15 signaling - Danio rerio
[Pathway:R-SSC-8983432] Interleukin-15 signaling - Sus scrofa
[Pathway:R-BTA-8983432] Interleukin-15 signaling - Bos taurus
[Pathway:R-CFA-8983432] Interleukin-15 signaling - Canis familiaris
[Pathway:R-RNO-8983432] Interleukin-15 signaling - Rattus norvegicus
[Pathway:R-MMU-8983432] Interleukin-15 signaling - Mus musculus
releaseDate
2017-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
[InstanceEdit:9014997] Patidar, Manoj, 2017-08-07
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8983432
summation
[Summation:8983261] The high affinity Interleukin-15 receptor is a heterotrimer ...
Referrals
(hasEvent)
[Pathway:R-HSA-451927] Interleukin-2 family signaling
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