Reactome | PIP3 recruits PDPK1 to the membrane

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PIP3 recruits PDPK1 to the membrane Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2316430] Orlic-Milacic, M, 2012-06-09
dbId	2316429
displayName	PIP3 recruits PDPK1 to the membrane
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
eventOf	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens [Pathway:R-HSA-1257604] PIP3 activates AKT signaling - Homo sapiens [Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens [Pathway:R-HSA-114604] GPVI-mediated activation cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-437192] PDPK1 binds PRKCZ - Homo sapiens [Reaction:R-HSA-2317314] AKT binds PDPK1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-202210] PDPK1 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2219518] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PIP3 recruits PDPK1 to the membrane
orthologousEvent	[Reaction:R-PFA-2316429] PIP3 recruits PDPK1 to the membrane - Plasmodium falciparum [Reaction:R-SCE-2316429] PIP3 recruits PDPK1 to the membrane - Saccharomyces cerevisiae [Reaction:R-SPO-2316429] PIP3 recruits PDPK1 to the membrane - Schizosaccharomyces pombe [Reaction:R-DDI-2316429] PIP3 recruits PDPK1 to the membrane - Dictyostelium discoideum [Reaction:R-CEL-2316429] PIP3 recruits PDPK1 to the membrane - Caenorhabditis elegans [Reaction:R-DME-2316429] PIP3 recruits PDPK1 to the membrane - Drosophila melanogaster [Reaction:R-GGA-2316429] PIP3 recruits PDPK1 to the membrane - Gallus gallus [Reaction:R-XTR-2316429] PIP3 recruits PDPK1 to the membrane - Xenopus tropicalis [Reaction:R-DRE-2316429] PIP3 recruits PDPK1 to the membrane - Danio rerio [Reaction:R-SSC-2316429] PIP3 recruits PDPK1 to the membrane - Sus scrofa [Reaction:R-BTA-2316429] PIP3 recruits PDPK1 to the membrane - Bos taurus [Reaction:R-CFA-2316429] PIP3 recruits PDPK1 to the membrane - Canis familiaris [Reaction:R-RNO-2316429] PIP3 recruits PDPK1 to the membrane - Rattus norvegicus [Reaction:R-MMU-2316429] PIP3 recruits PDPK1 to the membrane - Mus musculus
output	[Complex:R-HSA-377179] PDPK1:PIP3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Homo sapiens [Reaction:R-HSA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens [Reaction:R-HSA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
revised	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2316429
summation	[Summation:2326764] PIP3 generated by PI3K recruits phosphatidylinositide-depend...

Referrals

(hasEvent)	[Pathway:R-HSA-114604] GPVI-mediated activation cascade [Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability [Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling [Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(precedingEvent)	[Reaction:R-HSA-437192] PDPK1 binds PRKCZ [Reaction:R-HSA-2317314] AKT binds PDPK1

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