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Schema
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Entries
Regulation of TP53 Expression and Degradation
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created
[InstanceEdit:6806002] Orlic-Milacic, Marija, 2015-10-21
dbId
6806003
displayName
Regulation of TP53 Expression and Degradation
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf
[Pathway:R-HSA-5633007] Regulation of TP53 Activity - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-6804754] Regulation of TP53 Expression - Homo sapiens
[Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6804851] Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
[LiteratureReference:6804747] Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage
[LiteratureReference:3245948] The p53-mdm-2 autoregulatory feedback loop
[LiteratureReference:6804444] CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
[LiteratureReference:3209191] ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
[LiteratureReference:3209099] Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors
[LiteratureReference:3229104] MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1
[LiteratureReference:8856302] MDM2 and MDM4: p53 regulators as targets in anticancer therapy
[LiteratureReference:8856298] MDM2, MDMX and p53 in oncogenesis and cancer therapy
[LiteratureReference:3215288] Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
[LiteratureReference:8856311] Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
[LiteratureReference:8856313] The ubiquitin ligase COP1 is a critical negative regulator of p53
[LiteratureReference:8856332] Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage
[LiteratureReference:8856326] MicroRNA-125b is a novel negative regulator of p53
[LiteratureReference:8856335] Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
[LiteratureReference:8856323] Transcriptional and epigenetic regulation of the p53 tumor suppressor gene
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
Regulation of TP53 Expression and Degradation
orthologousEvent
[Pathway:R-CFA-6806003] Regulation of TP53 Expression and Degradation - Canis familiaris
[Pathway:R-SCE-6806003] Regulation of TP53 Expression and Degradation - Saccharomyces cerevisiae
[Pathway:R-SPO-6806003] Regulation of TP53 Expression and Degradation - Schizosaccharomyces pombe
[Pathway:R-DDI-6806003] Regulation of TP53 Expression and Degradation - Dictyostelium discoideum
[Pathway:R-CEL-6806003] Regulation of TP53 Expression and Degradation - Caenorhabditis elegans
[Pathway:R-DME-6806003] Regulation of TP53 Expression and Degradation - Drosophila melanogaster
[Pathway:R-XTR-6806003] Regulation of TP53 Expression and Degradation - Xenopus tropicalis
[Pathway:R-SSC-6806003] Regulation of TP53 Expression and Degradation - Sus scrofa
[Pathway:R-BTA-6806003] Regulation of TP53 Expression and Degradation - Bos taurus
[Pathway:R-DRE-6806003] Regulation of TP53 Expression and Degradation - Danio rerio
[Pathway:R-GGA-6806003] Regulation of TP53 Expression and Degradation - Gallus gallus
[Pathway:R-RNO-6806003] Regulation of TP53 Expression and Degradation - Rattus norvegicus
[Pathway:R-MMU-6806003] Regulation of TP53 Expression and Degradation - Mus musculus
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6806003
summation
[Summation:6806126] TP53 (p53) tumor suppressor protein is a transcription facto...
Referrals
(normalPathway)
[Pathway:R-HSA-9723905] Loss of function of TP53 in cancer due to loss of tetramerization ability
(hasEncapsulatedEvent)
[Pathway:R-HSA-201556] Signaling by ALK
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation
(hasEvent)
[Pathway:R-HSA-5633007] Regulation of TP53 Activity
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