Reactome | Regulation of TP53 Expression and Degradation

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Regulation of TP53 Expression and Degradation Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6806002] Orlic-Milacic, Marija, 2015-10-21
dbId	6806003
diseasePathways	[Pathway:R-HSA-9723905] Loss of function of TP53 in cancer due to loss of tetramerization ability - Homo sapiens
displayName	Regulation of TP53 Expression and Degradation
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-5633007] Regulation of TP53 Activity - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-6804754] Regulation of TP53 Expression - Homo sapiens [Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-06-12
literatureReference	[LiteratureReference:6804851] Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms [LiteratureReference:6804747] Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage [LiteratureReference:3245948] The p53-mdm-2 autoregulatory feedback loop [LiteratureReference:6804444] CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation [LiteratureReference:3209191] ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways [LiteratureReference:3209099] Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors [LiteratureReference:3229104] MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1 [LiteratureReference:8856302] MDM2 and MDM4: p53 regulators as targets in anticancer therapy [LiteratureReference:8856298] MDM2, MDMX and p53 in oncogenesis and cancer therapy [LiteratureReference:3215288] Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization [LiteratureReference:8856311] Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation [LiteratureReference:8856313] The ubiquitin ligase COP1 is a critical negative regulator of p53 [LiteratureReference:8856332] Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage [LiteratureReference:8856326] MicroRNA-125b is a novel negative regulator of p53 [LiteratureReference:8856335] Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin [LiteratureReference:8856323] Transcriptional and epigenetic regulation of the p53 tumor suppressor gene
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Regulation of TP53 Expression and Degradation
orthologousEvent	[Pathway:R-MMU-6806003] Regulation of TP53 Expression and Degradation - Mus musculus [Pathway:R-RNO-6806003] Regulation of TP53 Expression and Degradation - Rattus norvegicus [Pathway:R-CFA-6806003] Regulation of TP53 Expression and Degradation - Canis familiaris [Pathway:R-BTA-6806003] Regulation of TP53 Expression and Degradation - Bos taurus [Pathway:R-DME-6806003] Regulation of TP53 Expression and Degradation - Drosophila melanogaster [Pathway:R-SSC-6806003] Regulation of TP53 Expression and Degradation - Sus scrofa [Pathway:R-CEL-6806003] Regulation of TP53 Expression and Degradation - Caenorhabditis elegans [Pathway:R-SPO-6806003] Regulation of TP53 Expression and Degradation - Schizosaccharomyces pombe [Pathway:R-SCE-6806003] Regulation of TP53 Expression and Degradation - Saccharomyces cerevisiae [Pathway:R-GGA-6806003] Regulation of TP53 Expression and Degradation - Gallus gallus [Pathway:R-DDI-6806003] Regulation of TP53 Expression and Degradation - Dictyostelium discoideum [Pathway:R-DRE-6806003] Regulation of TP53 Expression and Degradation - Danio rerio [Pathway:R-XTR-6806003] Regulation of TP53 Expression and Degradation - Xenopus tropicalis
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6806003
summation	[Summation:6806126] TP53 (p53) tumor suppressor protein is a transcription facto...
updateTrackers	[UpdateTracker:9777685] Update Tracker - [Pathway:6806003] Regulation of TP53 Expression and Degradation - v69:[updateIndirectRLE] [UpdateTracker:9782777] Update Tracker - [Pathway:6806003] Regulation of TP53 Expression and Degradation - v58:[updateIndirectRLE] [UpdateTracker:9781958] Update Tracker - [Pathway:6806003] Regulation of TP53 Expression and Degradation - v60:[updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5633007] Regulation of TP53 Activity
(hasEncapsulatedEvent)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation [Pathway:R-HSA-1257604] PIP3 activates AKT signaling [Pathway:R-HSA-201556] Signaling by ALK
(normalPathway)	[Pathway:R-HSA-9723905] Loss of function of TP53 in cancer due to loss of tetramerization ability
(updatedInstance)	[UpdateTracker:9777685] Update Tracker - [Pathway:6806003] Regulation of TP53 Expression and Degradation - v69:[updateIndirectRLE] [UpdateTracker:9782777] Update Tracker - [Pathway:6806003] Regulation of TP53 Expression and Degradation - v58:[updateIndirectRLE] [UpdateTracker:9781958] Update Tracker - [Pathway:6806003] Regulation of TP53 Expression and Degradation - v60:[updateIndirectRLE]

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