Reactome | PIP3 activates AKT signaling

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556175
displayName	PIP3 activates AKT signaling
eventOf	[Pathway:R-SSC-9006925] Intracellular signaling by second messengers - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262292] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-114542] RAC1,RAC2,RHOG activate PI3K - Sus scrofa [Reaction:R-SSC-2316434] PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-SSC-2316429] PIP3 recruits PDPK1 to the membrane - Sus scrofa [Reaction:R-SSC-6795290] mTORC2 phosphorylates SGK1 - Sus scrofa [Reaction:R-SSC-6795473] PDPK1 phosphorylates SGK1 - Sus scrofa [Pathway:R-SSC-199418] Negative regulation of the PI3K/AKT network - Sus scrofa [Reaction:R-SSC-2219524] PDPK1 binds PIP2 - Sus scrofa [Pathway:R-SSC-6807070] PTEN Regulation - Sus scrofa
inferredFrom	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	PIP3 activates AKT signaling PI3K/AKT Signaling
precedingEvent	[BlackBoxEvent:R-SSC-198266] PI3K produces PIP3 and other phosphatidyl inositides - Sus scrofa
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-1257604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(inferredTo)	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(hasEvent)	[Pathway:R-SSC-9006925] Intracellular signaling by second messengers
(hasEncapsulatedEvent)	[Pathway:R-SSC-5687128] MAPK6/MAPK4 signaling [Pathway:R-SSC-1483255] PI Metabolism [Pathway:R-SSC-201556] Signaling by ALK [Pathway:R-SSC-9607240] FLT3 Signaling [Pathway:R-SSC-114604] GPVI-mediated activation cascade [Pathway:R-SSC-9614085] FOXO-mediated transcription [Pathway:R-SSC-5654741] Signaling by FGFR3 [Pathway:R-SSC-1227986] Signaling by ERBB2 [Pathway:R-SSC-187037] Signaling by NTRK1 (TRKA) [Pathway:R-SSC-6807070] PTEN Regulation [Pathway:R-SSC-5654736] Signaling by FGFR1 [Pathway:R-SSC-109606] Intrinsic Pathway for Apoptosis [Pathway:R-SSC-983705] Signaling by the B Cell Receptor (BCR) [Pathway:R-SSC-389356] Co-stimulation by CD28 [Pathway:R-SSC-5654743] Signaling by FGFR4 [Pathway:R-SSC-165159] MTOR signalling [Pathway:R-SSC-9034015] Signaling by NTRK3 (TRKC) [Pathway:R-SSC-9006115] Signaling by NTRK2 (TRKB) [Pathway:R-SSC-202403] TCR signaling [Pathway:R-SSC-9927354] Co-stimulation by ICOS [Pathway:R-SSC-202131] Metabolism of nitric oxide: NOS3 activation and regulation [Pathway:R-SSC-2454202] Fc epsilon receptor (FCERI) signaling [Pathway:R-SSC-2172127] DAP12 interactions [Pathway:R-SSC-5628897] TP53 Regulates Metabolic Genes [Pathway:R-SSC-6806003] Regulation of TP53 Expression and Degradation [Pathway:R-SSC-5625740] RHO GTPases activate PKNs [Pathway:R-SSC-177929] Signaling by EGFR [Pathway:R-SSC-9009391] Extra-nuclear estrogen signaling [Pathway:R-SSC-8983432] Interleukin-15 signaling [Pathway:R-SSC-186797] Signaling by PDGF [Pathway:R-SSC-1433557] Signaling by SCF-KIT [Pathway:R-SSC-1236394] Signaling by ERBB4 [Pathway:R-SSC-453279] Mitotic G1 phase and G1/S transition [Pathway:R-SSC-8848021] Signaling by PTK6 [Pathway:R-SSC-6806834] Signaling by MET [Pathway:R-SSC-5654738] Signaling by FGFR2

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