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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
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Cytomics
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POM121C [nuclear envelope]
Stable Identifier
R-HSA-6805165
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
Nuclear envelope pore membrane protein POM 121C, P121C_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)
CDK1 phosphorylates NUP98 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)
Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Partially Disassembled NPC [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
HSF1 trimer translocates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) (Homo sapiens)
Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
Defective NPC [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
HCMV Nuclear Pore Docking (Homo sapiens)
HCMV Capsid:Nuclear Pore Complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of HCMV DNA Into the Nucleus (Homo sapiens)
HCMV Capsid:Nuclear Pore Complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
HCMV Late Events (Homo sapiens)
Translocation of SCP, Triplex (TRI) complex, CVC complex, and Accessory Proteins from the cytoplasm into the nucleous (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Rev with host cellular proteins (Homo sapiens)
Nuclear import of Rev protein (Homo sapiens)
Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Rev-mediated nuclear export of HIV RNA (Homo sapiens)
Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Translocation of nuclear RNA transport complex to cytoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Interactions of Vpr with host cellular proteins (Homo sapiens)
Vpr-mediated nuclear import of PICs (Homo sapiens)
Vpr binds nucleoporins (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
PIC anchored to the NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Influenza Infection (Homo sapiens)
Export of Viral Ribonucleoproteins from Nucleus (Homo sapiens)
NEP/NS2 Interacts with the Cellular Export Machinery (Homo sapiens)
vRNP Export through the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Influenza Viral RNA Transcription and Replication (Homo sapiens)
Viral Messenger RNA Synthesis (Homo sapiens)
Export of Spliced Viral mRNA (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Viral mRNA Export (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of Ribonucleoproteins into the Host Nucleus (Homo sapiens)
Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Dimerized phospho-IRF3, IRF7 is transported to the nucleus (Homo sapiens)
6:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
SARS-CoV-2 6 binds NUP98:RAE1 within NPC (Homo sapiens)
6:NPC [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
Transcriptional regulation by small RNAs (Homo sapiens)
Importin-8 imports AGO2:miRNA into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Translocation of ISGF3 complex to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Homo sapiens)
Beta-catenin migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
IRF3 mediated activation of type 1 IFN (Homo sapiens)
Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of Glucokinase by Glucokinase Regulatory Protein (Homo sapiens)
NPC transports GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Metabolism of non-coding RNA (Homo sapiens)
snRNP Assembly (Homo sapiens)
Nuclear export of snRNA transcripts (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
snRNP nuclear import and release (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of the SLBP Dependant Mature mRNA (Homo sapiens)
Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA processing in the nucleus (Homo sapiens)
tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates TOP2A with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
SUMOylation of SUMOylation proteins (Homo sapiens)
RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
SUMOylation of ubiquitinylation proteins (Homo sapiens)
RANBP2 SUMOylates MDM2 with SUMO1 (Homo sapiens)
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
POM121 [nuclear envelope] (Homo sapiens)
POM121C [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:A8CG34 POM121C
Gene Names
POM121C
Chain
chain:1-1229
Reference Genes
COSMIC (genes):POM121C POM121C
ENSEMBL:ENSG00000272391 POM121C
HGNC:34005 POM121C
OMIM:615754 POM121C
UCSC:A8CG34 POM121C
Other Identifiers
100101267
11717556_s_at
11717557_s_at
11717558_s_at
11725974_s_at
11745659_s_at
11745660_x_at
212178_PM_s_at
212178_s_at
213360_PM_s_at
213360_s_at
2988471
3007445
3007448
3007451
3007452
3007455
3007457
3007458
3007477
3007482
3007483
3007485
3007486
3007487
3007492
3007493
3007495
3007496
3007497
3007498
3007499
3007501
3007502
3007503
3007504
3007505
3007506
3007508
3007509
3007511
3007512
3007513
3007515
3007516
3007557
3007558
3007562
3007563
3007564
3007565
3007566
3007567
3007568
3007569
3007570
3007571
3007572
3007574
3007575
3007576
3009585
3009587
3009598
3016712
3016714
3016717
3016721
3057167
3057168
3057169
3057170
3057171
3057172
3057173
3057174
3057175
3057176
3057177
3057178
3057179
3057180
3057181
3057182
3057183
3057184
3057185
3057187
3057189
3057190
3057191
3057192
3057193
3057194
3057261
3057265
3057267
3057269
3057271
3057273
3057292
3057293
3057297
3057298
3057299
3057300
3057320
3057322
3057329
3057331
3057767
3057770
3057771
3057772
3057773
3057774
3057776
3057777
3057779
3057799
40160_at
8133275
8133326
8133331
8140297
A_24_P349002
A_33_P3412233
GE81774
GE81960
GO:0005198
GO:0005515
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005783
GO:0005789
GO:0006405
GO:0006606
GO:0006886
GO:0006913
GO:0008139
GO:0015031
GO:0016020
GO:0017056
GO:0031965
GO:0043226
GO:0051028
HMNXSV003058439
Hs.295112.1.A1_3p_a_at
ILMN_1662130
TC07001530.hg
Participates
as a member of
POM121 [nuclear envelope] (Homo sapiens)
Inferred To
LOC110258677 [nuclear envelope]
(Sus scrofa)
Homologues of POM121C [nuclear envelope]
(Schizosaccharomyces pombe)
Homologues of POM121C [nuclear envelope]
(Sus scrofa)
Pom121 [nuclear envelope]
(Mus musculus)
Pom121 [nuclear envelope]
(Rattus norvegicus)
nup146 [nuclear envelope]
(Schizosaccharomyces pombe)
LOC100627016 [nuclear envelope]
(Sus scrofa)
nup124 [nuclear envelope]
(Schizosaccharomyces pombe)
NUP1 [nuclear envelope]
(Saccharomyces cerevisiae)
Nup214 [nuclear envelope]
(Drosophila melanogaster)
POM121C [nuclear envelope]
(Bos taurus)
POM121C [nuclear envelope]
(Canis familiaris)
POM121C [nuclear envelope]
(Gallus gallus)
POM121C [nuclear envelope]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000481575
,
ENST00000607367
,
ENST00000615331
,
ENSP00000476236
OpenTargets
ENSG00000272391
HPA
ENSG00000272391-POM121C
PRO
A8CG34
Pharos - Targets
A8CG34
GlyGen
A8CG34
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12004 PCNA
5
PCNA [nucleoplasm]
(R-HSA-68439)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
0.547
2
UniProt:Q14974 KPNB1
5
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
0.527
2
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