Reactome | ANG [extracellular region]

ANG [extracellular region]

Stable Identifier

R-HSA-5692435

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Angiogenin ecNumber3.1.27.-/ecNumber, ANGI_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P03950 ANG

Gene Names

ANG, RNASE5

Chain

signal peptide:1-24, chain:25-147

Reference Genes

BioGPS Gene:283 ANG

COSMIC (genes):ANG ANG

CTD Gene:283 ANG

dbSNP Gene:283 ANG

ENSEMBL:ENSG00000214274 ANG

ENSEMBL_homo_sapiens_GENE:ENSG00000214274.10 ANG

HGNC:483 ANG

KEGG Gene (Homo sapiens):283 ANG

Monarch:283 ANG

NCBI Gene:283 ANG

OMIM:105850 ANG

Reference Transcript

Other Identifiers

1103_at

11721569_a_at

16781573

205141_PM_at

205141_at

283

2891006

3023105

3382577

3527610

3527611

3527612

3527619

3527622

3527623

3527624

3527625

3527626

3645732

3645745

3645747

3677491

7973084

A_14_P106455

A_14_P123738

A_14_P123754

A_23_P428738

A_33_P3236177

GE57809

GO:0001525

GO:0001541

GO:0001556

GO:0001666

GO:0001890

GO:0001938

GO:0002376

GO:0003676

GO:0003677

GO:0003723

GO:0003779

GO:0003824

GO:0004518

GO:0004519

GO:0004521

GO:0004540

GO:0005102

GO:0005507

GO:0005515

GO:0005576

GO:0005604

GO:0005615

GO:0005634

GO:0005694

GO:0005730

GO:0005829

GO:0005856

GO:0006351

GO:0006399

GO:0006629

GO:0006651

GO:0007010

GO:0007154

GO:0007202

GO:0008092

GO:0008201

GO:0009303

GO:0009725

GO:0015629

GO:0016078

GO:0016477

GO:0016787

GO:0017148

GO:0019731

GO:0019843

GO:0022414

GO:0030041

GO:0030154

GO:0030312

GO:0030426

GO:0031012

GO:0031410

GO:0032148

GO:0032311

GO:0032431

GO:0036211

GO:0042277

GO:0042327

GO:0042592

GO:0042803

GO:0043025

GO:0043226

GO:0045087

GO:0048662

GO:0048856

GO:0048870

GO:0050714

GO:0050830

GO:0061844

GO:0065003

GO:0098542

GO:0140098

HMNXSV003000978

HMNXSV003030595

ILMN_1696974

ILMN_1760727

ILMN_2239408

ILMN_2294976

ILMN_2294978

M11567_rna1_at

TC05002160.hg

TC14000066.hg

TC14000067.hg

TC16000106.hg

TC16000111.hg

TC16000810.hg

g4557312_3p_at

Participates

as a component of

F-actin:ANG [plasma membrane] (Homo sapiens)

as an input of

ANG binds F-actin (Homo sapiens)

Other forms of this molecule

ANG [cytosol]

Inferred To

rnasel2 [extracellular region] (Danio rerio)

ANG1 [extracellular region] (Sus scrofa)

Homologues of ANG [extracellular region] (Bos taurus)

Homologues of ANG [extracellular region] (Danio rerio)

Homologues of ANG [extracellular region] (Gallus gallus)

rnasel4 [extracellular region] (Danio rerio)

ANG [extracellular region] (Bos taurus)

ANG [extracellular region] (Danio rerio)

ANG [extracellular region] (Gallus gallus)

ANG [extracellular region] (Mus musculus)

ANG2 [extracellular region] (Bos taurus)

Ang2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001136.1, NP_001091046.1

OpenTargets

ENSG00000214274

HPA

ENSG00000214274-ANG

GeneCards

P03950

Ensembl

ENST00000336811, ENSG00000214274, ENST00000397990, ENSP00000381077, ENSP00000336762

PRO

P03950

Pharos - Targets

P03950

Orphanet

17376

HMDB Protein

HMDBP01814

PDB

4AHL, 1B1I, 5M9S, 4AHK, 5M9C, 5M9T, 1B1E, 5EPZ, 4AHJ, 4AHI, 4AOH, 7NPM, 1K58, 1ANG, 7PNJ, 5M9M, 5EQO, 5M9P, 4AHN, 7PNP, 1HBY, 5M9Q, 4AHE, 8AF0, 4AHM, 1B1J, 1UN3, 7PNR, 5M9R, 5M9A, 1K5B, 2ANG, 4B36, 1K5A, 1H0D, 1GV7, 5M9G, 5M9V, 1K59, 5M9J, 5EOP, 4AHH, 4AHG, 1UN5, 1AWZ, 1A4Y, 1UN4, 4AHF, 1H53, 1H52, 4AHD

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13489 RINI			0.75	6
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.633	4
UniProt:Q03405 PLAUR	7	PLAUR [endoplasmic reticulum membrane] (R-HSA-162703) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [specific granule membrane] (R-HSA-6806143)	0.571	5
UniProt:P19883 FST	1	FST [extracellular region] (R-HSA-2473211)	0.571	3
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.537	4
UniProt:P60903 S100A10	1	S100A10 [external side of plasma membrane] (R-HSA-5336168)	0.484	8
UniProt:P07355 ANXA2	6	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) p-S26-ANXA2 [cytosol] (R-HSA-9865163) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.484	6

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