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GADD45A [nucleoplasm]
Stable Identifier
R-HSA-3215139
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
GADD45, DDIT1, Growth arrest and DNA damage-inducible protein GADD45 alpha, DNA damage-inducible transcript 1 protein
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
GADD45A gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)
GADD45A [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
GADD45A binds AURKA (Homo sapiens)
GADD45A [nucleoplasm] (Homo sapiens)
GADD45A:AURKA [nucleoplasm] (Homo sapiens)
GADD45A [nucleoplasm] (Homo sapiens)
GADD45A binds PCNA (Homo sapiens)
GADD45A [nucleoplasm] (Homo sapiens)
GADD45A:PCNA [nucleoplasm] (Homo sapiens)
GADD45A [nucleoplasm] (Homo sapiens)
TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)
GADD45A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24522 GADD45A
Gene Names
GADD45A, DDIT1, GADD45
Chain
chain:1-165
Reference Genes
BioGPS Gene:1647 GADD45A
COSMIC (genes):GADD45A GADD45A
CTD Gene:1647 GADD45A
dbSNP Gene:1647 GADD45A
ENSEMBL:ENSG00000116717 GADD45A
HGNC:4095 GADD45A
KEGG Gene (Homo sapiens):1647 GADD45A
Monarch:1647 GADD45A
NCBI Gene:1647 GADD45A
OMIM:126335 GADD45A
UCSC:P24522 GADD45A
Reference Transcript
RefSeq:NM_001199741.1 GADD45A
RefSeq:NM_001199742.1 GADD45A
RefSeq:NM_001924.3 GADD45A
Other Identifiers
0004150025
11717039_a_at
1647
16665932
1911_s_at
203725_at
2341089
2341090
2341091
2341094
2341096
2341098
2341099
2341100
2341101
7902227
A_14_P114342
A_23_P23221
GE57684
GO:0000079
GO:0000122
GO:0000185
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0006259
GO:0006281
GO:0006464
GO:0006469
GO:0006915
GO:0006950
GO:0006974
GO:0006977
GO:0007010
GO:0007049
GO:0007050
GO:0007098
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0016525
GO:0016607
GO:0019899
GO:0019900
GO:0033140
GO:0034641
GO:0040011
GO:0042770
GO:0042803
GO:0043065
GO:0043226
GO:0043537
GO:0046330
GO:0046982
GO:0047485
GO:0048646
GO:0048856
GO:0048870
GO:0051726
GO:0071260
GO:0071479
GO:0071850
GO:0071901
GO:1900745
GO:1990841
GO:2000379
ILMN_1694075
ILMN_2052208
M60974_s_at
PH_hs_0004630
TC01000745.hg
g9790904_3p_at
Participant Of
output
GADD45A gene expression is stimulated by FOXO3,FOXO4,(FOXO1)
GADD45A gene expression is stimulated by Foxo4
TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription
hasComponent
GADD45A:AURKA [nucleoplasm]
GADD45A:PCNA [nucleoplasm]
input
GADD45A binds AURKA
GADD45A binds PCNA
Inferred To
Gadd45 [nucleoplasm] (Drosophila melanogaster)
gadd45aa [nucleoplasm] (Danio rerio)
GADD45A [nucleoplasm] (Bos taurus)
GADD45A [nucleoplasm] (Canis familiaris)
GADD45A [nucleoplasm] (Gallus gallus)
GADD45A [nucleoplasm] (Sus scrofa)
Gadd45a [nucleoplasm] (Mus musculus)
Gadd45a [nucleoplasm] (Rattus norvegicus)
gadd45a [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_001186671.1
,
NP_001915.1
,
NP_001186670.1
Target Pathogen
5b354852be737e166372eb75
OpenTargets
ENSG00000116717
HPA
ENSG00000116717-GADD45A
GeneCards
P24522
Ensembl
ENSG00000116717
,
ENST00000370985
,
ENST00000370986
,
ENSP00000360024
,
ENSP00000360025
PRO
P24522
PDB
2KG4
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13561 DCTN2
1
DCTN2 [cytosol]
(R-HSA-380302)
0.742
7
UniProt:Q8TAE8 GADD45GIP1
1
GADD45GIP1 [mitochondrial matrix]
(R-HSA-5368253)
0.593
3
UniProt:P52564 MAP2K6
3
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
MAP2K6 [cytosol]
(R-HSA-167998)
0.573
2
UniProt:Q92600-3 CNOT9
0.556
5
UniProt:Q9HBI0 PARVG
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:Q14204 DYNC1H1
3
DYNC1H1 [azurophil granule lumen]
(R-HSA-6799155)
DYNC1H1 [extracellular region]
(R-HSA-6806223)
DYNC1H1 [cytosol]
(R-HSA-380285)
0.556
3
UniProt:P28715 ERCC5
1
ERCC5 [nucleoplasm]
(R-HSA-67447)
0.544
2
UniProt:Q13569 TDG
3
TDG [nucleoplasm]
(R-HSA-65812)
SUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
SUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
0.524
3
UniProt:Q9Y371 SHLB1
0.508
2
UniProt:P80303 NUCB2
0.508
2
UniProt:Q9GZX7 AICDA
0.499
5
UniProt:Q8NA61-2 CBY2
0.488
2
UniProt:Q8N448 LNX2
0.488
2
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