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MSH3 [nucleoplasm]
Stable Identifier
R-HSA-5357519
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA mismatch repair protein Msh3, MSH3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Mismatch Repair (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Homo sapiens)
EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) (Homo sapiens)
EXO1:MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)
EXO1:MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
Formation of MSH2:MSH3 Complex (Homo sapiens)
MSH2:MSH3:ADP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Homo sapiens)
MSH2:MSH3:ADP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ADP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MSH2:MSH3 exchanges ADP for ATP (Homo sapiens)
MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ADP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP:DNA containing IDL of 2 bases or more [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of Mismatch Repair (MMR) (Homo sapiens)
Defective Mismatch Repair Associated With MSH2 (Homo sapiens)
MSH2 variant:MSH3-defective DNA mismatch repair (Homo sapiens)
MSH3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20585 MSH3
Gene Names
MSH3, DUC1, DUG
Chain
chain:1-1137
Reference Genes
BioGPS Gene:4437 MSH3
COSMIC (genes):MSH3 MSH3
CTD Gene:4437 MSH3
dbSNP Gene:4437 MSH3
ENSEMBL:ENSG00000113318 MSH3
HGNC:7326 MSH3
KEGG Gene (Homo sapiens):4437 MSH3
Monarch:4437 MSH3
NCBI Gene:4437 MSH3
OMIM:600887 MSH3
UCSC:P20585 MSH3
Reference Transcript
RefSeq:NM_002439.4 MSH3
Other Identifiers
0000840739
11731032_at
11731033_at
16986748
17126222
1719_at
205887_3p_x_at
205887_PM_x_at
205887_x_at
210947_PM_s_at
210947_s_at
2817839
2817840
2817844
2817847
2817848
2817849
2817850
2817851
2817856
2817857
2817858
2817866
2817868
2817870
2817871
2817881
2817882
2817883
2817886
2817887
2817890
2817892
2817895
2817896
2817907
2817908
2817910
2817912
2817913
2817914
2817915
8106633
A_14_P117964
A_14_P122052
A_14_P123827
A_14_P139372
A_23_P122001
A_24_P203479
GE59286
GO:0000166
GO:0002376
GO:0003674
GO:0003677
GO:0003690
GO:0003697
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006259
GO:0006281
GO:0006298
GO:0006312
GO:0006950
GO:0006974
GO:0008150
GO:0016020
GO:0016447
GO:0019899
GO:0030983
GO:0032139
GO:0032142
GO:0032181
GO:0032302
GO:0032991
GO:0034641
GO:0043167
GO:0043226
GO:0043570
GO:0045910
GO:0048856
GO:0051096
GO:0051276
HMNXSV003035413
ILMN_2077130
J04810_s_at
PH_hs_0003124
TC05000400.hg
U61981_at
g181841_3p_a_at
g4505248_3p_at
Participates
as an input of
MSH2 variant:MSH3-defective DNA mismatch repair (Homo sapiens)
Formation of MSH2:MSH3 Complex (Homo sapiens)
as a component of
MSH2:MSH3:ADP [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MSH3 414TER [nucleoplasm]
Inferred To
MSH3 [nucleoplasm]
(Bos taurus)
MSH3 [nucleoplasm]
(Canis familiaris)
MSH3 [nucleoplasm]
(Gallus gallus)
MSH3 [nucleoplasm]
(Sus scrofa)
Msh3 [nucleoplasm]
(Mus musculus)
Msh3 [nucleoplasm]
(Rattus norvegicus)
msh3 [nucleoplasm]
(Danio rerio)
msh3 [nucleoplasm]
(Dictyostelium discoideum)
msh3 [nucleoplasm]
(Schizosaccharomyces pombe)
msh3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002430.3
OpenTargets
ENSG00000113318
GeneCards
P20585
HPA
ENSG00000113318-MSH3
Ensembl
ENSG00000113318
,
ENSP00000265081
,
ENST00000265081
PRO
P20585
Pharos - Targets
P20585
Orphanet
25490
PDB
3THW
,
3THZ
,
3THX
,
3THY
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43246 MSH2
3
MSH2 [nucleoplasm]
(R-HSA-5357525)
MSH2 GLN601TER [nucleoplasm]
(R-HSA-5577243)
MSH2 R406* [nucleoplasm]
(R-HSA-5575594)
0.851
10
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.742
5
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.718
6
UniProt:Q9NXL9 MCM9
0.462
2
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