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CDT1 [nucleoplasm]
Stable Identifier
R-HSA-68536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
CDT1 gene expression is stimulated by E2F1 (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1 binds MCM2-7 (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDT1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H211 CDT1
Gene Names
CDT1
Chain
chain:1-546
Reference Genes
BioGPS Gene:81620 CDT1
COSMIC (genes):CDT1 CDT1
CTD Gene:81620 CDT1
dbSNP Gene:81620 CDT1
ENSEMBL:ENSG00000167513 CDT1
HGNC:24576 CDT1
KEGG:hsa:81620 CDT1
Monarch:81620 CDT1
NCBI Gene:81620 CDT1
OMIM:605525 CDT1
UCSC:Q9H211 CDT1
Reference Transcript
RefSeq:NM_030928.3 CDT1
Other Identifiers
11721666_at
11721667_a_at
11721668_at
16821869
209832_PM_s_at
209832_s_at
228868_PM_x_at
228868_x_at
34510_at
3673691
3673692
3673693
3673694
3673695
3673696
3673697
3673698
3673699
3673700
3673701
3673702
3673703
3673704
3673705
3673706
3673707
3673708
7997839
81620
A_14_P114944
A_23_P37704
A_24_P176374
A_33_P3386262
GE54632
GO:0000076
GO:0000278
GO:0000775
GO:0000776
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006260
GO:0016604
GO:0030174
GO:0033262
GO:0035563
GO:0043226
GO:0045740
GO:0045786
GO:0051301
GO:0051315
GO:0065003
GO:0070182
GO:0071163
GO:0072708
GO:2000104
GO:2000105
HMNXSV003045252
Hs.122908.1.S1_3p_at
ILMN_1651237
PH_hs_0006882
TC16000686.hg
g12007404_3p_a_at
Participates
as an output of
CDT1 gene expression is stimulated by E2F1 (Homo sapiens)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:GMNN [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
as an input of
CDT1 binds MCM2-7 (Homo sapiens)
CDT1 binds geminin (Homo sapiens)
Inferred To
cdt1 [nucleoplasm]
(Schizosaccharomyces pombe)
cdt1 [nucleoplasm]
(Xenopus tropicalis)
Cdt1 [nucleoplasm]
(Mus musculus)
Cdt1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of CDT1 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of CDT1 [nucleoplasm]
(Saccharomyces cerevisiae)
cdt-1 [nucleoplasm]
(Caenorhabditis elegans)
dup [nucleoplasm]
(Drosophila melanogaster)
CDT1 [nucleoplasm]
(Bos taurus)
CDT1 [nucleoplasm]
(Canis familiaris)
CDT1 [nucleoplasm]
(Gallus gallus)
CDT1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_112190.2
ENSEMBL
ENST00000301019
,
ENSP00000301019
OpenTargets
ENSG00000167513
HPA
ENSG00000167513-CDT1
PRO
Q9H211
Pharos - Targets
Q9H211
Orphanet
CDT1
PDB
2WVR
,
6QCG
,
2LE8
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.975
22
UniProt:P20248 CCNA2
3
CCNA2 [nucleoplasm]
(R-HSA-68905)
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
0.725
7
UniProt:Q14566 MCM6
1
MCM6 [nucleoplasm]
(R-HSA-68553)
0.656
4
UniProt:P24941 CDK2
5
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
CDK2 [nucleoplasm]
(R-HSA-68365)
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
0.643
3
UniProt:Q99741 CDC6
4
CDC6 [cytosol]
(R-HSA-113566)
p-CDC6 [cytosol]
(R-HSA-68583)
p-CDC6 [nucleoplasm]
(R-HSA-5661317)
CDC6 [nucleoplasm]
(R-HSA-68542)
0.609
3
UniProt:O14777 NDC80
1
NDC80 [cytosol]
(R-HSA-375314)
0.567
7
UniProt:Q00526 CDK3
0.527
3
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.527
2
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.527
2
UniProt:P33552 CKS2
0.527
2
UniProt:P06493 CDK1
11
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
CDK1 [cytosol]
(R-HSA-170075)
CDK1 [nucleoplasm]
(R-HSA-68889)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
0.527
2
UniProt:P12004 PCNA
5
PCNA [nucleoplasm]
(R-HSA-68439)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
0.499
2
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