p16INK4A R80TER [cytosol]

Stable Identifier
R-HSA-9632586
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p16INK4A Arg80TER, p16INK4A R80*, p16INK4A Arg80*, CDKN2A R80TER, CDKN2A Arg80TER, CDKN2A R80*, CDKN2A Arg80*
p16INK4A R80TER [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
9354451 CDKN2A/p16 is inactivated in most melanoma cell lines

Castellano, M, Pollock, PM, Walters, MK, Sparrow, LE, Down, LM, Gabrielli, BG, Parsons, PG, Hayward, NK

Cancer Res. 1997
21053367 C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells

Fahham, N, Sardari, S, Ostad, SN, Vaziri, B, Ghahremani, MH

J. Cell. Biochem. 2010
External Reference Information
External Reference
Gene Names
CDKN2A, CDKN2, MTS1
Chain
chain:1-156
Other Identifiers
0002570204
0005130288
1029
11718293_a_at
1713_s_at
18232
1A5E
1BI7
1DC2
207039_at
209644_x_at
211156_at
2A5E
3201447
3201448
3201450
3201451
3201457
3201458
3201459
3201460
3201461
3201464
3201465
3201466
3201467
3201477
3201478
3201483
445
73132_r_at
8160441
93
A_23_P43484
A_23_P43490
A_33_P3411628
AAA92554
AAB60645
AAD11437
AAD14048
AAD14050
AAR05391
AB060808
ABC47036
AF115544
AF527803
AFN61598
AFN61599
AFN61600
AH007355
AL449423
BAB91133
CAA63870
CAB000093
CAB000445
CAB018232
CCDS56565
CCDS6510
CCDS87644
CDKN2A
CDKN2A-201
CDKN2A-203
CDKN2A-206
CDKN2A-208
CDKN2A-209
CDKN2A-212
CH471071
DQ318021
EAW58598
EAW58599
EAW58603
ENSG00000147889
ENSP00000307101
ENSP00000369496
ENSP00000418915
ENSP00000464952
ENSP00000467390
ENSP00000467857
ENST00000304494
ENST00000304494.9
ENST00000380151
ENST00000380151.3
ENST00000494262
ENST00000494262.5
ENST00000498124
ENST00000498124.1
ENST00000498628
ENST00000498628.6
ENST00000578845
ENST00000578845.2
EntrezGene:1029
g1353569_3p_a_at
g1353569_3p_x_at
g4206166_3p_a_at
g4502748_3p_at
GE59038
GO:0000082
GO:0001953
GO:0003674
GO:0003723
GO:0004861
GO:0005515
GO:0005575
GO:0005634
GO:0005737
GO:0005829
GO:0006950
GO:0007049
GO:0007050
GO:0007165
GO:0007265
GO:0007568
GO:0008134
GO:0008150
GO:0008285
GO:0016301
GO:0016310
GO:0019899
GO:0019901
GO:0022607
GO:0030234
GO:0030308
GO:0032088
GO:0034393
GO:0035985
GO:0035986
GO:0042326
GO:0043226
GO:0045736
GO:0045892
GO:0051059
GO:0090398
GO:0090399
GO:2000111
GO:2000134
GO:2000774
HGNC:1787
ILMN_1717714
ILMN_1757255
IPR020683
IPR036770
J3QRG6
JQ694043
JQ694044
JQ694045
K7ENC6
K7ES20
K7PML8
L27211
LRG_11
MIM:155601
MIM:155755
MIM:600160
MIM:606719
NM_000077
NM_001195132
NM_058197
NP_000068
NP_001182061
NP_001350692
NP_478104
PH_hs_0019731
Q8N726
S69804
U12818
U12819
U12820
U26727_at
UPI0000047FDA
UPI000014576F
UPI000036760F
UPI0001565711
X94154
XM_005251343
XM_011517679
XP_005251400
XP_011515981
Participant Of
Other forms of this molecule
Disease
Name Identifier Synonyms
esophagus adenocarcinoma 4914 Oesophageal adenocarcinoma, adenocarcinoma of esophagus
astrocytoma 3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
pancreatic ductal adenocarcinoma 3498 ductal adenocarcinoma of the pancreas
cancer 162 malignant tumor, malignant neoplasm, primary cancer
acute lymphocytic leukemia 9952
melanoma 1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
ovarian cancer 2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
rhabdomyosarcoma 3247 Rhabdomyosarcoma NOS (morphologic abnormality), rhabdomyosarcoma, Rhabdomyosarcoma, no subtype (morphologic abnormality), rhabdomyoblastoma, Rhabdomyosarcoma (disorder)
endometrial cancer 1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
lung cancer 1324
gallbladder adenocarcinoma 3500 adenocarcinoma of the gallbladder
bile duct carcinoma 4897
penis carcinoma 3449 Penile carcinoma, carcinoma of penis (disorder)
hepatocellular carcinoma 684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
esophagus squamous cell carcinoma 3748 SCC of esophagus, squamous cell carcinoma of esophagus
Barrett's esophagus 9206 Barrett's ulcer of esophagus, Barrett's oesophagus, ulcerative esophagitis, Barrett's esophagus with esophagitis, Barrett esophagus, CLE, Barretts syndrome
prostate adenocarcinoma 2526 adenocarcinoma of prostate (disorder), prostate adenocarcinoma
lung squamous cell carcinoma 3907 squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
salivary gland cancer 8850 malignant neoplasm of salivary gland NOS, malignant tumor of the Salivary gland, malignant neoplasm of salivary gland duct, malignant neoplasm of major salivary gland, NOS, malignant neoplasm of major salivary gland NOS (disorder), malignant neoplasm of major salivary gland NOS, malignant neoplasm of salivary gland, malignant neoplasm of salivary gland, unspecified, malignant tumor of salivary gland (disorder), malignant tumor of major salivary gland (disorder), malignant tumor of the Major Salivary gland, malignant neoplasm of major salivary gland, malignant neoplasm of other major salivary glands (disorder), malignant neoplasm of other major salivary glands
skin squamous cell carcinoma 3151 Epidermoid skin carcinoma, squamous cell carcinoma of skin (disorder)
peripheral T-cell lymphoma 0050749
renal clear cell carcinoma 4467 conventional renal cell carcinoma, Clear cell carcinoma of kidney (disorder), conventional (Clear cell) renal cell carcinoma
follicular lymphoma 0050873
basal cell carcinoma 2513 malignant Basal cell neoplasm, malignant basal cell tumor, malignant basal cell tumor (morphologic abnormality), Basal cell cancer, BASAL CELL carcinoma OF SKIN, Rodent ulcer, Rodent ulcer, Basal cell carcinoma NOS (morphologic abnormality), Basal cell neoplasm NOS (morphologic abnormality), Rodent ulcer, basal cell carcinoma, Basal cell carcinoma (morphologic abnormality), Epithelioma basal cell (disorder), basal cell neoplasm, Basal cell neoplasm (morphologic abnormality), Basal cell tumor (morphologic abnormality), Rodent ulcer, Basal cell carcinoma of skin (disorder), Basal cell tumor
acute myeloid leukemia 9119 Leukemia, Myelocytic, acute, acute myeloblastic leukemia, acute myelogenous leukemia, AML - acute Myeloid Leukemia
papillary renal cell carcinoma 4465 Chromophil carcinoma of kidney, sporadic papillary renal cell carcinoma, papillary kidney carcinoma, Papillary renal cell carcinoma
oral squamous cell carcinoma 0050866 mouth squamous cell carcinoma
bladder carcinoma 4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
chondrosarcoma 3371 primary chondrosarcoma of the bone, chondrosarcoma of bone
larynx cancer 2596
large intestine cancer 5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
small intestine carcinoma 4907 small intestinal carcinoma
head and neck squamous cell carcinoma 5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
breast cancer 1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
thyroid carcinoma 3963 head and neck cancer, Thyroid
vulva squamous cell carcinoma 2101 squamous cell carcinoma of vulva, Vulvar Epidermoid carcinoma, vulvar squamous cell carcinoma
peripheral primitive neuroectodermal tumor 3369 Ewings sarcoma-primitive neuroectodermal tumor, Ewing's sarcoma/peripheral primitive neuroectodermal tumor, Ewing's tumor, Ewing's tumor, Ewings sarcoma, Ewing sarcoma, PNET of Thoracopulmonary Region
nasopharynx carcinoma 9261 malignant neoplasm of nasopharynx, malignant neoplasm of anterior wall of nasopharynx, malignant neoplasm of lateral wall of nasopharynx, malignant tumor of lateral wall of nasopharynx, Nasopharyngeal carcinoma, carcinoma of nasopharynx, malignant tumor of posterior wall of nasopharynx, malignant Nasopharyngeal tumor, malignant neoplasm of posterior wall of nasopharynx, malignant neoplasm of nasopharyngeal wall, malignant neoplasm of other specified sites of nasopharynx, primary malignant neoplasm of anterior wall of nasopharynx, malignant tumor of anterior wall of nasopharynx, malignant neoplasm of roof of nasopharynx, malignant neoplasm of superior wall of nasopharynx, nasopharynx cancer
sebaceous carcinoma 4840 malignant Sebaceous tumor, malignant neoplasm of sebaceous gland
lung adenocarcinoma 3910 nonsmall cell adenocarcinoma
oral mucosa leukoplakia 9655
diffuse large B-cell lymphoma 0050745
non-small cell lung carcinoma 3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
keratoacanthoma 3149
liposarcoma 3382
Cross References
OpenTargets
GeneCards
PRO
Orphanet
PDB
Interactors (11)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P11802 CDK4  3 0.944 14
 UniProt:Q00534 CDK6  3 0.907 14
 UniProt:P12004 PCNA  5 0.61 8
 UniProt:P02730 SLC4A1  8 0.602 5
 UniProt:Q6UXH1 CREL2      0.508 2
 UniProt:Q8NHU6 TDRD7      0.508 2
 UniProt:O75398 DEAF1      0.508 2
 UniProt:Q00839 HNRNPU  1 0.508 2
 UniProt:Q14566 MCM6  1 0.499 4
 UniProt:P24385 CCND1  4 0.491 2
 UniProt:P62826 RAN  2 0.463 2