Reactome | CCNE1 [cytosol]

CCNE1 [cytosol]

Stable Identifier

R-HSA-157443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

G1/S-specific cyclin E1

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        Formation of Cyclin E:Cdk2 complexes (Homo sapiens)
        
        CCNE [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        CCNE:CDK2 [cytosol] (Homo sapiens)
        
        CCNE [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Activated PTK6 binds CDKN1B (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        PTK6 phosphorylates CDKN1B (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)
        
        CCNE:CDK2 [cytosol] (Homo sapiens)
        
        CCNE [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
      - G1/S-Specific Transcription (Homo sapiens)
        
        CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Activated PTK6 binds CDKN1B (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        PTK6 phosphorylates CDKN1B (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates Cell Cycle (Homo sapiens)
      - Activated PTK6 binds CDKN1B (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
      - PTK6 phosphorylates CDKN1B (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
        
        p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        Cyclin E1:CDK2 [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - RHOBTB3 ATPase cycle (Homo sapiens)
    - RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)
      - RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)
      - RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Homo sapiens)
        
        RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
        
        CCNE1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24864 CCNE1

Gene Names

CCNE1, CCNE

Chain

chain:1-410

Reference Genes

BioGPS Gene:898 CCNE1

COSMIC (genes):CCNE1 CCNE1

CTD Gene:898 CCNE1

dbSNP Gene:898 CCNE1

ENSEMBL:ENSG00000105173 CCNE1

ENSEMBL_homo_sapiens_GENE:ENSG00000105173.14 CCNE1

HGNC:1589 CCNE1

KEGG Gene (Homo sapiens):898 CCNE1

Monarch:898 CCNE1

NCBI Gene:898 CCNE1

OMIM:123837 CCNE1

UCSC:P24864 CCNE1

Reference Transcript

Other Identifiers

11724406_a_at

11724407_s_at

16860418

2021_s_at

213523_PM_at

213523_at

3828126

3828127

3828128

3828129

3828131

3828132

3828133

3828134

3828135

3828136

3828137

3828138

3828139

3828140

3828141

3828142

41060_at

8027402

898

A_14_P125491

A_23_P209200

GE88019

GO:0000082

GO:0000122

GO:0000278

GO:0000307

GO:0000723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006260

GO:0006270

GO:0006351

GO:0006355

GO:0006468

GO:0007049

GO:0007059

GO:0007129

GO:0016055

GO:0016301

GO:0016538

GO:0016740

GO:0019901

GO:0022414

GO:0023052

GO:0032200

GO:0032880

GO:0036211

GO:0043226

GO:0051301

GO:0051726

GO:0070192

GO:0097134

GO:0098772

GO:0140013

GO:1902462

HMNXSV003040007

Hs.9700.0.S1_3p_at

ILMN_1733419

ILMN_1795852

ILMN_2374425

ILMN_2384785

M74093_at

PH_hs_0023204

TC19000416.hg

X95406_at

Participates

as a member of

as a component of

Cyclin E1:CDK2 [cytosol] (Homo sapiens)

as an output of

CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)

Other forms of this molecule

CCNE1 [nucleoplasm]

Unfolded CCNE1 [cytosol]

Inferred To

cye-1 [cytosol] (Caenorhabditis elegans)

Ccne1 [cytosol] (Mus musculus)

Ccne1 [cytosol] (Rattus norvegicus)

ccne1 [cytosol] (Danio rerio)

ccne1 [cytosol] (Xenopus tropicalis)

CCNE1 [cytosol] (Bos taurus)

CCNE1 [cytosol] (Canis familiaris)

CCNE1 [cytosol] (Gallus gallus)

CCNE1 [cytosol] (Sus scrofa)

CycE [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001229.1, NP_001309191.1

OpenTargets

ENSG00000105173

ZINC - Substances

CCNE1_HUMAN

HPA

ENSG00000105173-CCNE1

GeneCards

P24864

ZINC target

P24864

Ensembl

ENSP00000262643, ENST00000444983, ENST00000262643, ENSG00000105173, ENSP00000410179

PRO

P24864

Pharos - Targets

P24864

ZINC - Predictions - Purchasable

CCNE1_HUMAN

PDB

8H6P, 8H6T, 7XQK, 8VQ3, 5L2W, 1W98, 8VQ4, 8H4R, 7KJS

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.966	26
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.888	12
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.853	11
UniProt:Q00526 CDK3			0.643	4
UniProt:Q96PU4 UHRF2	1	UHRF2 [nucleoplasm] (R-HSA-976050)	0.602	4
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.581	3
UniProt:A6NCL1 GEMC1			0.556	3
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.544	2
UniProt:P33552 CKS2			0.527	2
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.527	2
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.527	3
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.527	2
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064)	0.527	2
UniProt:Q5VK71 AKAP8			0.524	2
UniProt:P06788 VE7			0.524	2
UniProt:Q9I9K6 Q9I9K6			0.499	2