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POLD2 [nucleoplasm]
Stable Identifier
R-HSA-68443
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA pol delta subunit 2, DNA polymerase delta subunit 2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Formation of Okazaki fragments (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
RPA binds to the Flap (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Formation of C-strand Okazaki fragments (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate on the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate from the C-strand (Homo sapiens)
RPA binds to the Flap on the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap from the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
Termination of translesion DNA synthesis (Homo sapiens)
POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Mismatch Repair (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Homo sapiens)
DNA polymerase delta polymerizes DNA across single stranded gap (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Homo sapiens)
DNA polymerase delta polymerizes DNA across single stranded gap (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Dual Incision in GG-NER (Homo sapiens)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
POLD,POLE [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Formation of Okazaki fragments (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
RPA binds to the Flap (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap (Homo sapiens)
Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Leading Strand Synthesis (Homo sapiens)
Polymerase switching (Homo sapiens)
Formation of Processive Complex (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
Processive complex [nucleoplasm] (Homo sapiens)
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
POLD2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49005 POLD2
Gene Names
POLD2
Chain
chain:1-469
Reference Genes
BioGPS Gene:5425 POLD2
COSMIC (genes):POLD2 POLD2
CTD Gene:5425 POLD2
dbSNP Gene:5425 POLD2
ENSEMBL:ENSG00000106628 POLD2
HGNC:9176 POLD2
KEGG:hsa:5425 POLD2
Monarch:5425 POLD2
NCBI Gene:5425 POLD2
OMIM:600815 POLD2
UCSC:P49005 POLD2
Reference Transcript
RefSeq:NM_006230.3 POLD2
RefSeq:NM_001127218.2 POLD2
RefSeq:NM_001256879.1 POLD2
Other Identifiers
11720605_a_at
11757482_x_at
1470_at
17057174
201115_PM_at
201115_at
216175_PM_at
216175_at
2820325
2820326
2820327
3048412
3048414
3048415
3048416
3048417
3048418
3048419
3048420
3048421
3048422
3048423
3048424
3048425
3048426
3048427
3048428
3048429
3048430
3048431
3048432
3048433
3048434
3048435
3048436
3048437
3048438
3048439
3048440
3048441
3048442
3048443
3048444
3048445
5425
8139299
90047_at
A_23_P71146
A_24_P620648
GE59007
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0006259
GO:0006260
GO:0006261
GO:0006271
GO:0006281
GO:0016035
GO:0042276
GO:0043226
GO:0043625
GO:0071897
HMNXSV003032459
Hs.306791.0.S1_3p_at
ILMN_1746252
PH_hs_0027367
PH_hs_0037505
TC07001334.hg
U21090_at
g5453923_3p_at
Participates
as a component of
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
Inferred To
cdc1 [nucleoplasm]
(Schizosaccharomyces pombe)
PolD2 [nucleoplasm]
(Drosophila melanogaster)
Pold2 [nucleoplasm]
(Mus musculus)
Pold2 [nucleoplasm]
(Rattus norvegicus)
polD2 [nucleoplasm]
(Dictyostelium discoideum)
POL31 [nucleoplasm]
(Saccharomyces cerevisiae)
POLD2 [nucleoplasm]
(Bos taurus)
POLD2 [nucleoplasm]
(Caenorhabditis elegans)
POLD2 [nucleoplasm]
(Canis familiaris)
POLD2 [nucleoplasm]
(Plasmodium falciparum)
POLD2 [nucleoplasm]
(Sus scrofa)
pold2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001243808.1
,
NP_006221.2
,
NP_001120690.1
ENSEMBL
ENST00000406581
,
ENST00000452185
,
ENSP00000406702
,
ENSP00000514053
,
ENSP00000480186
,
ENSP00000514051
,
ENSP00000514052
,
ENST00000610533
,
ENSP00000386105
,
ENST00000698945
,
ENST00000418438
,
ENSP00000395231
,
ENST00000698947
,
ENST00000698946
OpenTargets
ENSG00000106628
HPA
ENSG00000106628-POLD2
PRO
P49005
Pharos - Targets
P49005
GlyGen
P49005
HMDB Protein
HMDBP11715
PDB
6TNY
,
6S1O
,
6S1N
,
6S1M
,
3E0J
,
6TNZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12004 PCNA
5
PCNA [nucleoplasm]
(R-HSA-68439)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
0.678
3
UniProt:O60673 REV3L
1
REV3L [nucleoplasm]
(R-HSA-110278)
0.527
3
UniProt:P53041 PPP5C
2
PPP5C [nucleoplasm]
(R-HSA-5683410)
PPP5C [cytosol]
(R-HSA-5675402)
0.527
3
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