Reactome | B2M(21-119) [early endosome lumen]

B2M(21-119) [early endosome lumen]

Stable Identifier

R-HSA-1236827

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome lumen

Synonyms

Beta-2-microglobulin

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P61769 B2M

Gene Names

B2M, CDABP0092, HDCMA22P

Chain

signal peptide:1-20, chain:21-119, chain:22-119

Reference Genes

COSMIC (genes):B2M B2M

dbSNP Gene:567 B2M

ENSEMBL:ENSG00000166710 B2M

Participates

as a component of

Class I MHC:B2M [early endosome membrane] (Homo sapiens)

Other forms of this molecule

B2M(21-119) [plasma membrane]

B2M(21-119) [endoplasmic reticulum lumen]

B2M(21-119) [specific granule lumen]

B2M(21-119) [extracellular region]

B2M(21-119) [tertiary granule lumen]

B2M(21-119) [Golgi membrane]

B2M(21-119) [ER to Golgi transport vesicle membrane]

B2M(21-119) [recycling endosome membrane]

B2M(21-119) [phagocytic vesicle membrane]

B2M(21-119) [early endosome membrane]

Inferred To

B2m [early endosome lumen] (Mus musculus)

B2m [early endosome lumen] (Rattus norvegicus)

Homologues of B2M(21-119) [early endosome lumen] (Danio rerio)

b2m [early endosome lumen] (Danio rerio)

B2M(21-119) [early endosome lumen] (Canis familiaris)

B2M [early endosome lumen] (Bos taurus)

B2M [early endosome lumen] (Gallus gallus)

B2M [early endosome lumen] (Sus scrofa)

zmp:0000001138 [early endosome lumen] (Danio rerio)

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.984	36
UniProt:P01889 HLA-B	8	class I MHC B7 [lumenal side of endoplasmic reticulum membrane] (R-HSA-983073) class I MHC B7 [secretory granule membrane] (R-HSA-6804794) class I MHC B7 [plasma membrane] (R-HSA-167756) class I MHC B7 [Golgi membrane] (R-HSA-983379) class I MHC B7 [ER to Golgi transport vesicle membrane] (R-HSA-983362) class I MHC B7 [early endosome membrane] (R-HSA-1236872) class I MHC B7 [recycling endosome membrane] (R-HSA-8863942) class I MHC B7 [phagocytic vesicle membrane] (R-HSA-1236753)	0.93	16
UniProt:P10321 HLA-C	8	HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236760) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane] (R-HSA-8863915) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (R-HSA-1236799) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983354) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane] (R-HSA-983387) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (R-HSA-199595) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane] (R-HSA-6803292) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983044)	0.875	11
UniProt:P01892 1A02			0.786	22
UniProt:P29016 CD1B	1	CD1B [plasma membrane] (R-HSA-197793)	0.779	6
UniProt:P04439 HLA-A	9	HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983100) HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane] (R-HSA-983376) HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] (R-HSA-197642) HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983347) HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane] (R-HSA-1236826) HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane] (R-HSA-8863889) HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236740) HLA-A A-3 [endoplasmic reticulum membrane] (R-HSA-8943090) K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073)	0.77	10
UniProt:Q30201 HFE	1	HFE [plasma membrane] (R-HSA-5691126)	0.734	5
UniProt:P17693 HLA-G	7	HLA class I histocompatibility antigen, alpha chain G precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983065) HLA class I histocompatibility antigen, alpha chain G precursor [Golgi membrane] (R-HSA-983382) HLA class I histocompatibility antigen, alpha chain G precursor [plasma membrane] (R-HSA-197575) HLA class I histocompatibility antigen, alpha chain G precursor [ER to Golgi transport vesicle membrane] (R-HSA-983406) HLA class I histocompatibility antigen, alpha chain G precursor [early endosome membrane] (R-HSA-1236831) HLA class I histocompatibility antigen, alpha chain G precursor [recycling endosome membrane] (R-HSA-8863906) HLA class I histocompatibility antigen, alpha chain G precursor [phagocytic vesicle membrane] (R-HSA-1236782)	0.702	4
UniProt:P55899 FCGRN			0.688	5
UniProt:P06126 CD1A	1	CD1A [plasma membrane] (R-HSA-197792)	0.623	2
UniProt:Q95460-1 MR1			0.618	3
UniProt:P30511 HLA-F	7	HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983093) HLA class I histocompatibility antigen, alpha chain F precursor [Golgi membrane] (R-HSA-983394) HLA class I histocompatibility antigen, alpha chain F precursor [plasma membrane] (R-HSA-197572) HLA class I histocompatibility antigen, alpha chain F precursor [ER to Golgi transport vesicle membrane] (R-HSA-983375) HLA class I histocompatibility antigen, alpha chain F precursor [early endosome membrane] (R-HSA-1236895) HLA class I histocompatibility antigen, alpha chain F precursor [recycling endosome membrane] (R-HSA-8863878) HLA class I histocompatibility antigen, alpha chain F precursor [phagocytic vesicle membrane] (R-HSA-1236887)	0.59	5
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.573	3
ChEBI:28304 HEPARIN			0.564	2
UniProt:P02786 TFRC	5	TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124)	0.564	3
UniProt:Q9Y3Y4 PYGO1	1	PYGO1 [nucleoplasm] (R-HSA-201705)	0.556	3
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.527	4
UniProt:O14524 NEMP1			0.527	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.527	3
UniProt:Q99666 RGPD5			0.527	4
UniProt:O60507 TPST1	1	TPST1 [Golgi membrane] (R-HSA-8954253)	0.527	2
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.527	3
UniProt:Q69YH5 CDCA2			0.527	2
UniProt:P15812 CD1E			0.527	2
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.527	4
UniProt:Q06203 PPAT	1	PPAT [cytosol] (R-HSA-62496)	0.527	3
UniProt:P46060 RANGAP1	3	RANGAP1 [cytosol] (R-HSA-376255) RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416)	0.527	4
UniProt:P0DJD1 RGPD2			0.527	3
UniProt:Q03518 TAP1	3	TAP1 [endoplasmic reticulum membrane] (R-HSA-947474) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [phagocytic vesicle membrane] (R-HSA-1236845)	0.527	3
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.527	3
IntAct:EBI-15716597 ACTIN			0.524	3
UniProt:P59596 M	10	M [plasma membrane] (R-COV-9731038) M [Golgi membrane] (R-COV-9683651) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.524	2
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.524	2

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