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About
What is Reactome ?
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Our Logo
License Agreement
Privacy Notice
Disclaimer
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Table of Contents
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CCNE1 [nucleoplasm]
Stable Identifier
R-HSA-68363
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
G1/S-specific cyclin E1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
RBL1:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
RBL2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E/A [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
Association of Rb with Cyclin E:Cdk2 complexes (Homo sapiens)
CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:p-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:p-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Homo sapiens)
Cyclin E:CDK2-mediated phosphorylation of RB1 (Homo sapiens)
CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cdc6 protein is phosphorylated by CDK (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cdc6 protein is phosphorylated by CDK (Homo sapiens)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CCNE:CDK2 [nucleoplasm] (Homo sapiens)
Cyclin E [nucleoplasm] (Homo sapiens)
CCNE1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24864 CCNE1
Gene Names
CCNE1, CCNE
Chain
chain:1-410
Reference Genes
BioGPS Gene:898 CCNE1
COSMIC (genes):CCNE1 CCNE1
CTD Gene:898 CCNE1
dbSNP Gene:898 CCNE1
ENSEMBL:ENSG00000105173.14 CCNE1
HGNC:1589 CCNE1
KEGG Gene (Homo sapiens):898 CCNE1
Monarch:898 CCNE1
NCBI Gene:898 CCNE1
OMIM:123837 CCNE1
UCSC:P24864 CCNE1
Reference Transcript
RefSeq:NM_001238.3 CCNE1
RefSeq:NM_001322262.1 CCNE1
Other Identifiers
0000840131
0006840112
11724406_a_at
11724407_s_at
16860418
2021_s_at
213523_PM_at
213523_at
3828126
3828127
3828128
3828129
3828131
3828132
3828133
3828134
3828135
3828136
3828137
3828138
3828139
3828140
3828141
3828142
41060_at
8027402
898
A_14_P125491
A_23_P209200
GE88019
GO:0000079
GO:0000082
GO:0000122
GO:0000278
GO:0000307
GO:0000723
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006260
GO:0006270
GO:0006351
GO:0006355
GO:0006468
GO:0007049
GO:0007059
GO:0007129
GO:0016055
GO:0016301
GO:0016538
GO:0016740
GO:0019901
GO:0022414
GO:0023052
GO:0032200
GO:0032880
GO:0032991
GO:0036211
GO:0043226
GO:0044772
GO:0051301
GO:0051726
GO:0070192
GO:0097134
GO:0098772
GO:0140013
GO:1902462
HMNXSV003040007
Hs.9700.0.S1_3p_at
ILMN_1733419
ILMN_1795852
ILMN_2374425
ILMN_2384785
M74093_at
PH_hs_0023204
TC19000416.hg
X95406_at
Participates
as a candidate of
Cyclin E [nucleoplasm] (Homo sapiens)
as a member of
Cyclin E [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Unfolded CCNE1 [cytosol]
CCNE1 [cytosol]
Inferred To
CCNE1 [nucleoplasm]
(Bos taurus)
CCNE1 [nucleoplasm]
(Canis familiaris)
CCNE1 [nucleoplasm]
(Gallus gallus)
CCNE1 [nucleoplasm]
(Sus scrofa)
ccne1 [nucleoplasm]
(Danio rerio)
CLB6 [nucleoplasm]
(Saccharomyces cerevisiae)
CLB1 [nucleoplasm]
(Saccharomyces cerevisiae)
CLB2 [nucleoplasm]
(Saccharomyces cerevisiae)
Ccne1 [nucleoplasm]
(Mus musculus)
Ccne1 [nucleoplasm]
(Rattus norvegicus)
cycB [nucleoplasm]
(Dictyostelium discoideum)
CLB3 [nucleoplasm]
(Saccharomyces cerevisiae)
CLB4 [nucleoplasm]
(Saccharomyces cerevisiae)
CycE [nucleoplasm]
(Drosophila melanogaster)
cig2 [nucleoplasm]
(Schizosaccharomyces pombe)
cye-1 [nucleoplasm]
(Caenorhabditis elegans)
CLB5 [nucleoplasm]
(Saccharomyces cerevisiae)
puc1 [nucleoplasm]
(Schizosaccharomyces pombe)
CLN3 [nucleoplasm]
(Saccharomyces cerevisiae)
cig1 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of CCNE1 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of CCNE1 [nucleoplasm]
(Schizosaccharomyces pombe)
CLN1 [nucleoplasm]
(Saccharomyces cerevisiae)
CLN2 [nucleoplasm]
(Saccharomyces cerevisiae)
cdc13 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001309191.1
,
NP_001229.1
OpenTargets
ENSG00000105173
GeneCards
P24864
ZINC - Substances
CCNE1_HUMAN
HPA
ENSG00000105173-CCNE1
Ensembl
ENSP00000410179
,
ENST00000262643
,
ENSP00000262643
,
ENSG00000105173
,
ENST00000444983
ZINC target
P24864
PRO
P24864
Pharos - Targets
P24864
ZINC - Predictions - Purchasable
CCNE1_HUMAN
PDB
7KJS
,
5L2W
,
1W98
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.962
22
UniProt:P46527 CDKN1B
8
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
CDKN1B [cytosol]
(R-HSA-198622)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.851
10
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.809
9
UniProt:Q96PU4 UHRF2
1
UHRF2 [nucleoplasm]
(R-HSA-976050)
0.602
4
UniProt:Q969H0 FBXW7
1
FBXW7 [cytosol]
(R-HSA-391304)
0.581
3
UniProt:A6NCL1 GEMC1
0.556
3
UniProt:Q08050 FOXM1
3
p-T611,S730,S739-FOXM1 [nucleoplasm]
(R-HSA-4088133)
p-T611-FOXM1 [nucleoplasm]
(R-HSA-4088026)
FOXM1 [nucleoplasm]
(R-HSA-4088019)
0.544
2
UniProt:Q00526 CDK3
0.527
2
UniProt:Q5VK71 AKAP8
0.524
2
UniProt:P06788 VE7
0.524
2
UniProt:Q9I9K6 Q9I9K6
0.499
2
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![CCNE1 [nucleoplasm] icon](/icon/R-ICO-012524.svg){kind=icon}
