Reactome | CCNE1 [nucleoplasm]

CCNE1 [nucleoplasm]

Stable Identifier

R-HSA-68363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

G1/S-specific cyclin E1

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
        
        CCNE:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNE:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G0 and Early G1 (Homo sapiens)
      - p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        RBL1:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
      - p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
      - p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        RBL2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
      - p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
    - G1 Phase (Homo sapiens)
      - Cyclin D associated events in G1 (Homo sapiens)
        
        RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        Association of Rb with Cyclin E:Cdk2 complexes (Homo sapiens)
        
        CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        CAK-mediated phosphorylation of Cyclin E:Cdk2 (Homo sapiens)
        
        CCNE:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Homo sapiens)
        
        CCNE:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
        
        CCNE:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNE:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)
        
        CCNE:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Homo sapiens)
        
        Cyclin E:CDK2-mediated phosphorylation of RB1 (Homo sapiens)
        
        CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitination of phospho-p27/p21 (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)
        
        CCNE:CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Ubiquitination of phospho-p27/p21 (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
        
        Cdc6 protein is phosphorylated by CDK (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- Synthesis of DNA (Homo sapiens)
  - Switching of origins to a post-replicative state (Homo sapiens)
    - CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
      - Cdc6 protein is phosphorylated by CDK (Homo sapiens)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        Cyclin E:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        Cyclin E [nucleoplasm] (Homo sapiens)
        
        CCNE1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24864 CCNE1

Gene Names

CCNE1, CCNE

Chain

chain:1-410

Reference Genes

BioGPS Gene:898 CCNE1

COSMIC (genes):CCNE1 CCNE1

CTD Gene:898 CCNE1

dbSNP Gene:898 CCNE1

ENSEMBL:ENSG00000105173 CCNE1

HGNC:1589 CCNE1

KEGG Gene (Homo sapiens):898 CCNE1

Monarch:898 CCNE1

NCBI Gene:898 CCNE1

OMIM:123837 CCNE1

UCSC:P24864 CCNE1

Reference Transcript

Other Identifiers

0000840131

0006840112

11724406_a_at

11724407_s_at

16860418

2021_s_at

213523_at

3828126

3828127

3828128

3828129

3828131

3828132

3828133

3828134

3828135

3828136

3828137

3828138

3828139

3828140

3828141

3828142

41060_at

8027402

898

A_14_P125491

A_23_P209200

GE88019

GO:0000003

GO:0000079

GO:0000082

GO:0000083

GO:0000122

GO:0000278

GO:0000307

GO:0000723

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006259

GO:0006270

GO:0006464

GO:0006468

GO:0007049

GO:0007059

GO:0007129

GO:0007165

GO:0007267

GO:0008150

GO:0008283

GO:0009058

GO:0016055

GO:0016301

GO:0016538

GO:0019899

GO:0019901

GO:0030234

GO:0032991

GO:0034641

GO:0042592

GO:0043226

GO:0044772

GO:0051276

GO:0051301

GO:0051726

GO:0070192

GO:0097134

GO:1902462

GO:1903827

HMNXSV003040007

Hs.9700.0.S1_3p_at

ILMN_1733419

ILMN_1795852

ILMN_2374425

ILMN_2384785

M74093_at

PH_hs_0023204

TC19000416.hg

X95406_at

Participates

as a candidate of

Cyclin E [nucleoplasm] (Homo sapiens)

as a member of

Cyclin E [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Unfolded CCNE1 [cytosol]

CCNE1 [cytosol]

Inferred To

CCNE1 [nucleoplasm] (Canis familiaris)

CCNE1 [nucleoplasm] (Dictyostelium discoideum)

CCNE1 [nucleoplasm] (Gallus gallus)

ccne1 [nucleoplasm] (Danio rerio)

CLB6 [nucleoplasm] (Saccharomyces cerevisiae)

CLB1 [nucleoplasm] (Saccharomyces cerevisiae)

CLB2 [nucleoplasm] (Saccharomyces cerevisiae)

Ccne1 [nucleoplasm] (Mus musculus)

Ccne1 [nucleoplasm] (Rattus norvegicus)

cycA [nucleoplasm] (Dictyostelium discoideum)

CycE [nucleoplasm] (Drosophila melanogaster)

cig2 [nucleoplasm] (Schizosaccharomyces pombe)

cye-1 [nucleoplasm] (Caenorhabditis elegans)

CLB5 [nucleoplasm] (Saccharomyces cerevisiae)

puc1 [nucleoplasm] (Schizosaccharomyces pombe)

CLN3 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CCNE1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of CCNE1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CCNE1 [nucleoplasm] (Schizosaccharomyces pombe)

CLN1 [nucleoplasm] (Saccharomyces cerevisiae)

CLN2 [nucleoplasm] (Saccharomyces cerevisiae)

cdc13 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001309191.1, NP_001229.1

OpenTargets

ENSG00000105173

HPA

ENSG00000105173-CCNE1

GeneCards

P24864

ZINC - Substances

CCNE1_HUMAN

Ensembl

ENSP00000262643, ENSG00000105173, ENSP00000410179, ENST00000262643, ENST00000444983

ZINC target

P24864

PRO

P24864

Pharos - Targets

P24864

ZINC - Predictions - Purchasable

CCNE1_HUMAN

PDB

5L2W, 1W98

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [cytosol] (R-HSA-157440)	0.962	22
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512)	0.809	9
UniProt:P46527 CDKN1B	8	p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-S10 CDKN1B [cytosol] (R-HSA-9632829) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808)	0.806	8
UniProt:Q96PU4 UHRF2	1	UHRF2 [nucleoplasm] (R-HSA-976050)	0.602	4
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.581	3
UniProt:A6NCL1 GEMC1			0.556	3
UniProt:Q08050 FOXM1	3	FOXM1 [nucleoplasm] (R-HSA-4088019) p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026)	0.544	2
UniProt:Q00526 CDK3			0.527	2
UniProt:Q5VK71 AKAP8			0.524	2
UniProt:P06788 VE7			0.524	2
UniProt:Q9I9K6 Q9I9K6			0.499	2

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