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monoSUMO1-K195-ING2 [nucleoplasm]
Stable Identifier
R-HSA-4086075
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Inhibitor of growth protein 2, Inhibitor of growth 1-like protein, ING1Lp, p32, p33ING2, ING1L
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of ING2 with SUMO1 (Homo sapiens)
monoSUMO1-K195-ING2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
20676127
Sumoylation of ING2 regulates the transcription mediated by Sin3A
Pedeux, R
,
Binda, O
,
Binet, R
,
Brambilla, C
,
Gazzeri, S
,
Larrieu, D
,
Ythier, D
Oncogene
2010
External Reference Information
External Reference
UniProt:Q9H160 ING2
Gene Names
ING2, ING1L
Chain
chain:1-280
Reference Genes
BioGPS Gene:3622 ING2
COSMIC (genes):ING2 ING2
CTD Gene:3622 ING2
dbSNP Gene:3622 ING2
ENSEMBL:ENSG00000168556 ING2
HGNC:6063 ING2
KEGG Gene (Homo sapiens):3622 ING2
Monarch:3622 ING2
NCBI Gene:3622 ING2
OMIM:604215 ING2
UCSC:Q9H160 ING2
Reference Transcript
RefSeq:NM_001291959.1 ING2
RefSeq:NM_001564.3 ING2
Other Identifiers
0000380315
11727091_a_at
11758969_at
16972764
16972770
205981_PM_s_at
205981_s_at
2753954
2753960
2753961
2753962
2753963
2753964
2753965
3622
39555_at
8098508
A_14_P202213
A_21_P0003866
A_23_P83736
GE483109
GE81044
GO:0000003
GO:0000122
GO:0000228
GO:0003674
GO:0003677
GO:0003682
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005886
GO:0006325
GO:0006355
GO:0006464
GO:0006950
GO:0007049
GO:0007141
GO:0007165
GO:0007283
GO:0007286
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0008289
GO:0009058
GO:0016580
GO:0016602
GO:0030154
GO:0030317
GO:0030336
GO:0030511
GO:0030512
GO:0031065
GO:0032991
GO:0034641
GO:0035064
GO:0035091
GO:0040007
GO:0040008
GO:0040011
GO:0042393
GO:0042981
GO:0043167
GO:0043226
GO:0044877
GO:0045893
GO:0046872
GO:0048133
GO:0048856
GO:0048870
GO:0051276
GO:0051301
GO:0072520
GO:1902166
GO:1902455
GO:1902459
GO:2000772
GO:2001020
GO:2001234
HMNXSV003046945
ILMN_1671265
ILMN_2085722
PH_hs_0027204
TC04000890.hg
TC04002351.hg
g4504694_3p_at
Participates
as an output of
SUMOylation of ING2 with SUMO1 (Homo sapiens)
Other forms of this molecule
ING2 [nucleoplasm]
Inferred To
YNG1 [nucleoplasm]
(Saccharomyces cerevisiae)
ing2 [nucleoplasm]
(Danio rerio)
ing2 [nucleoplasm]
(Xenopus tropicalis)
PHO23 [nucleoplasm]
(Saccharomyces cerevisiae)
ING2 [nucleoplasm]
(Bos taurus)
ING2 [nucleoplasm]
(Gallus gallus)
Homologues of monoSUMO1-K195-ING2 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of monoSUMO1-K195-ING2 [nucleoplasm]
(Schizosaccharomyces pombe)
Ing2 [nucleoplasm]
(Mus musculus)
Ing2 [nucleoplasm]
(Rattus norvegicus)
YNG2 [nucleoplasm]
(Saccharomyces cerevisiae)
png2 [nucleoplasm]
(Schizosaccharomyces pombe)
png1 [nucleoplasm]
(Schizosaccharomyces pombe)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 195
Coordinate
195
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001278888.1
,
NP_001555.1
OpenTargets
ENSG00000168556
GeneCards
Q9H160
HPA
ENSG00000168556-ING2
Ensembl
ENST00000302327
,
ENSP00000307183
,
ENSG00000168556
PRO
Q9H160
Pharos - Targets
Q9H160
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.564
2
UniProt:Q9HCE7-2 SMURF1
0.544
3
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.544
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
2
UniProt:O75446 SAP30
1
SAP30 [nucleoplasm]
(R-HSA-351693)
0.527
2
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