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SETD3 [nucleoplasm]
Stable Identifier
R-HSA-5688411
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase setd3 ecNumber2.1.1.43/ecNumber, SETD3_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
SETD3 [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
SETD3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86TU7 SETD3
Gene Names
SETD3, C14orf154
Chain
chain:1-594
Reference Genes
BioGPS Gene:84193 SETD3
COSMIC (genes):SETD3 SETD3
CTD Gene:84193 SETD3
dbSNP Gene:84193 SETD3
ENSEMBL:ENSG00000183576 SETD3
ENSEMBL_homo_sapiens_GENE:ENSG00000183576.13 SETD3
HGNC:20493 SETD3
KEGG Gene (Homo sapiens):84193 SETD3
Monarch:84193 SETD3
NCBI Gene:84193 SETD3
OMIM:615671 SETD3
UCSC:Q86TU7 SETD3
Reference Transcript
RefSeq:XM_011537231.2 SETD3
RefSeq:XM_011537232.2 SETD3
RefSeq:NM_032233.2 SETD3
RefSeq:XM_017021700.1 SETD3
RefSeq:NM_199123.1 SETD3
RefSeq:XM_011537235.1 SETD3
RefSeq:XM_017021699.1 SETD3
Other Identifiers
11731766_at
11741046_s_at
11745201_a_at
11753285_a_at
11753286_x_at
16796607
212465_PM_at
212465_at
229940_PM_at
229940_at
33915_at
3579208
3579209
3579210
3579212
3579213
3579214
3579215
3579216
3579218
3579219
3579225
3579227
3579242
3579243
3579245
3579246
3579247
3579248
3579251
50982_at
7981249
84193
A_23_P25989
A_33_P3365524
GE87634
GO:0000785
GO:0003012
GO:0003713
GO:0003779
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0007010
GO:0008092
GO:0008168
GO:0008170
GO:0008757
GO:0016740
GO:0018021
GO:0018064
GO:0030047
GO:0030154
GO:0032259
GO:0036211
GO:0042800
GO:0043226
GO:0045893
GO:0045944
GO:0046975
GO:0048856
GO:0051149
GO:0061629
GO:0070472
GO:0140096
GO:0140110
HMNXSV003024428
HMNXSV003029615
Hs.321766.0.S1_3p_at
Hs.39635.0.A1_3p_at
ILMN_1679577
ILMN_1724504
ILMN_1756328
PH_hs_0016066
TC14001499.hg
Participates
as a member of
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
Inferred To
SETD3 [nucleoplasm]
(Bos taurus)
SETD3 [nucleoplasm]
(Canis familiaris)
SETD3 [nucleoplasm]
(Mus musculus)
SETD3 [nucleoplasm]
(Plasmodium falciparum)
SETD3 [nucleoplasm]
(Rattus norvegicus)
SETD3 [nucleoplasm]
(Saccharomyces cerevisiae)
SETD3 [nucleoplasm]
(Schizosaccharomyces pombe)
SETD3 [nucleoplasm]
(Sus scrofa)
cnrI [nucleoplasm]
(Dictyostelium discoideum)
set-27 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_011535533.2
,
XP_016877189.1
,
XP_011535534.1
,
XP_016877188.1
,
NP_115609.2
,
NP_954574.1
,
XP_011535537.1
OpenTargets
ENSG00000183576
GeneCards
Q86TU7
HPA
ENSG00000183576-SETD3
Ensembl
ENSP00000327910
,
ENSP00000327436
,
ENST00000331768
,
ENSG00000183576
,
ENST00000329331
PRO
Q86TU7
Pharos - Targets
Q86TU7
HMDB Protein
HMDBP11950
PDB
6WK2
,
6OX4
,
6JAT
,
7W28
,
6ICV
,
6MBK
,
6WK1
,
6OX3
,
6MBL
,
6OX2
,
7LMS
,
6OX1
,
3SMT
,
6MBJ
,
6ICT
,
6V63
,
6OX0
,
6V62
,
6OX5
,
7W29
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.508
3
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