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CASP10(220-415) [cytosol]
Stable Identifier
R-HSA-933458
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CASP10, Casp-10 p23/p17, Caspase-10 subunit p23/17
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
Processing of caspases (Homo sapiens)
CASP10(220-415) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92851 CASP10
Gene Names
CASP10, MCH4
Chain
propeptide:1-219, chain:220-415, chain:416-521
Reference Genes
BioGPS Gene:843 CASP10
COSMIC - genes:CASP10 CASP10
CTD Gene:843 CASP10
dbSNP Gene:843 CASP10
ENSEMBL:ENSG00000003400 CASP10
HGNC:1500 CASP10
KEGG:hsa:843 CASP10
Monarch:843 CASP10
NCBI Gene:843 CASP10
OMIM:601762 CASP10
UCSC:Q92851 CASP10
Reference Transcript
RefSeq:NM_001306083.2 CASP10
RefSeq:NM_001206524.2 CASP10
RefSeq:NM_001206542.2 CASP10
RefSeq:NM_001230.4 CASP10
RefSeq:NM_032977.3 CASP10
RefSeq:NM_032974.4 CASP10
RefSeq:NM_032976.4 CASP10
Participates
as an output of
Processing of caspases (Homo sapiens)
Other forms of this molecule
CASP10(1-521) [cytosol]
CASP10(416-521) [cytosol]
CASP10(1-219) [cytosol]
Cross References
RefSeq
NP_116756.2
,
NP_116758.1
,
NP_001293012.1
,
NP_116759.2
,
NP_001193453.1
,
NP_001193471.1
,
NP_001221.2
Guide to Pharmacology - Targets
1626
OpenTargets
ENSG00000003400
ENSEMBL
ENSG00000003400
,
ENST00000272879
,
ENST00000286186
,
ENSP00000272879
,
ENST00000448480
,
ENSP00000512459
,
ENSP00000237865
,
ENST00000346817
,
ENST00000374650
,
ENSP00000286186
,
ENST00000313728
,
ENSP00000363781
,
ENSP00000396835
,
ENSP00000314599
,
ENST00000492363
ZINC - Substances
CASPA_HUMAN
ZINC target
Q92851
PRO
Q92851
IntEnz
3.4.22.63
HPA
ENSG00000003400-CASP10
GeneCards
CASP10
Pharos - Targets
Q92851
Orphanet
CASP10
ZINC - Predictions - Purchasable
CASPA_HUMAN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.75
4
UniProt:Q14790 CASP8
8
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
0.734
6
UniProt:O14730 RIOK3
1
RIOK3 [cytosol]
(R-HSA-6791522)
0.725
6
UniProt:O15519 CFLAR
1
CFLAR(1-376) [cytosol]
(R-HSA-51925)
0.65
3
UniProt:P98170 XIAP
4
XIAP [cytosol]
(R-HSA-50849)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
XIAP [cytosol]
(R-HSA-114444)
0.556
3
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