Reactome | p-S196-CASP9(1-416) [cytosol]

p-S196-CASP9(1-416) [cytosol]

Stable Identifier

R-HSA-198636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S196-CASP9, Phospho-Caspase-9

Icon

Locations in the PathwayBrowser

Expand all

General

any remaining instances associated here should be reassociated with the complex Cleaved Caspase-9

External Reference Information

External Reference

UniProt:P55211 CASP9

Gene Names

CASP9, MCH6

Chain

propeptide:1-, chain:-315, propeptide:316-330, chain:331-416

Reference Genes

BioGPS Gene:842 CASP9

COSMIC (genes):CASP9 CASP9

CTD Gene:842 CASP9

dbSNP Gene:842 CASP9

ENSEMBL:ENSG00000132906 CASP9

HGNC:1511 CASP9

KEGG:hsa:842 CASP9

Monarch:842 CASP9

NCBI Gene:842 CASP9

OMIM:602234 CASP9

UCSC:P55211 CASP9

Reference Transcript

Other Identifiers

11741401_a_at

11748782_a_at

16681996

203984_PM_s_at

203984_s_at

210775_PM_x_at

210775_x_at

237451_PM_x_at

237451_x_at

2397696

2397697

2397698

2397699

2397700

2397701

2397702

2397703

2397704

2397705

2397706

2397707

2397708

2397710

2397711

2397713

2397714

2397715

2397716

2397717

2397718

2397719

2397720

2397721

2397722

2397723

2397725

2397726

240437_PM_at

240437_at

486_at

487_g_at

7912646

842

A_23_P97309

A_24_P111342

GE59272

GO:0001666

GO:0001822

GO:0002931

GO:0003824

GO:0004197

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0006508

GO:0006915

GO:0006974

GO:0008047

GO:0008233

GO:0008234

GO:0008303

GO:0008630

GO:0008635

GO:0009411

GO:0012501

GO:0014070

GO:0016485

GO:0016787

GO:0017124

GO:0019901

GO:0030154

GO:0030220

GO:0032025

GO:0032355

GO:0032496

GO:0032991

GO:0034349

GO:0034644

GO:0042770

GO:0042802

GO:0042981

GO:0043065

GO:0043226

GO:0043293

GO:0043525

GO:0044346

GO:0048856

GO:0051402

GO:0051604

GO:0071407

GO:0071549

GO:0071887

GO:0097153

GO:0097193

GO:0097199

GO:0098772

GO:0140096

GO:1904019

HMNXSV003028640

Hs.34174.1.A1_3p_at

ILMN_1718070

ILMN_1786046

PH_hs_0023824

TC01002245.hg

U60521_at

g1532150_3p_s_at

g5103139_3p_s_at

Participates

as an output of

Other forms of this molecule

CASP9(1-416) [cytosol]

CASP9(?-315) [cytosol]

CASP9(331-416) [cytosol]

p-T412-CASP9(1-416) [cytosol]

Inferred To

Homologues of p-S196-CASP9(1-416) [cytosol] (Drosophila melanogaster)

phospho-Damm [cytosol] (Drosophila melanogaster)

phospho-Strica [cytosol] (Drosophila melanogaster)

phospho-ced-3 [cytosol] (Caenorhabditis elegans)

phospho-p-S196-CASP9(1-416) [cytosol] (Gallus gallus)

phospho-Casp9 [cytosol] (Mus musculus)

phospho-Casp9 [cytosol] (Rattus norvegicus)

phospho-Drice [cytosol] (Drosophila melanogaster)

phospho-Decay [cytosol] (Drosophila melanogaster)

phospho-casp20 [cytosol] (Danio rerio)

phospho-Dcp-1 [cytosol] (Drosophila melanogaster)

phospho-casp9 [cytosol] (Xenopus tropicalis)

phospho-Dredd [cytosol] (Drosophila melanogaster)

phospho-CASP9 [cytosol] (Bos taurus)

phospho-CASP9 [cytosol] (Canis familiaris)

phospho-CASP9 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 196

Coordinate

196

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001264983.1, NP_127463.2, NP_001220.2, XP_005246071.1

Guide to Pharmacology - Targets

1625

OpenTargets

ENSG00000132906

ENSEMBL

ENST00000348549, ENSP00000365051, ENST00000375890, ENSP00000330237, ENST00000333868, ENSP00000255256

ZINC - Substances

CASP9_HUMAN

ZINC target

P55211

PRO

P55211

GlyGen

P55211

PDB

5WVC, 4RHW, 5JUY, 2AR9, 5WVE, 1JXQ, 1NW9, 3V3K, 3YGS, 3D9T

IntEnz

3.4.22.62

HPA

ENSG00000132906-CASP9

Pharos - Targets

P55211

ZINC - Predictions - Purchasable

CASP9_HUMAN

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.97	25
UniProt:O14727 APAF1	4	APAF1 [ficolin-1-rich granule lumen] (R-HSA-6801301) APAF1 [extracellular region] (R-HSA-6806465) APAF1 [secretory granule lumen] (R-HSA-6801271) APAF1 [cytosol] (R-HSA-50099)	0.964	25
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.924	12
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.919	12
UniProt:Q8XAL7 NLEF			0.724	6
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.644	3
UniProt:P43146 DCC	4	p-Y1420-DCC [plasma membrane] (R-HSA-374552) DCC(1291-1447) [cytosol] (R-HSA-373629) DCC [plasma membrane] (R-HSA-197560) DCC(26-1290) [plasma membrane] (R-HSA-373627)	0.589	2
IntAct:EBI-23188321 CCSB ORF ID			0.556	3
UniProt:Q6PIA0 Q6PIA0			0.556	3
IntAct:EBI-10214943 112401			0.556	3
UniProt:P83105 HTRA4			0.547	5
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.536	2
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.519	2

Cite Us!