Reactome | CASP10(1-219) [cytosol]

CASP10(1-219) [cytosol]

Stable Identifier

R-HSA-933454

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casp-10 prodomain, Caspase-10 prodomain

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
      - Processing of caspases (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP10(1-219) [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP10(1-219) [cytosol] (Homo sapiens)
      - Recruitment of IKK complex (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        FADD:Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP10(1-219) [cytosol] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        FADD:Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP10(1-219) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92851 CASP10

Gene Names

CASP10, MCH4

Chain

propeptide:1-219, chain:220-415, chain:416-521

Reference Genes

BioGPS Gene:843 CASP10

COSMIC (genes):CASP10 CASP10

CTD Gene:843 CASP10

dbSNP Gene:843 CASP10

ENSEMBL:ENSG00000003400 CASP10

HGNC:1500 CASP10

KEGG:hsa:843 CASP10

Monarch:843 CASP10

NCBI Gene:843 CASP10

OMIM:601762 CASP10

UCSC:Q92851 CASP10

Reference Transcript

Participates

as a member of

Casp-8/10 prodomain [cytosol] (Homo sapiens)

Other forms of this molecule

CASP10(1-521) [cytosol]

CASP10(416-521) [cytosol]

CASP10(220-415) [cytosol]

Cross References

Guide to Pharmacology - Targets

1626

OpenTargets

ENSG00000003400

ENSEMBL

ENSP00000237865, ENSP00000512459, ENSP00000363781, ENSG00000003400, ENSP00000286186, ENST00000313728, ENSP00000272879, ENST00000374650, ENST00000346817, ENST00000492363, ENST00000448480, ENSP00000314599, ENSP00000396835, ENST00000272879, ENST00000286186

IntEnz

3.4.22.63

HPA

ENSG00000003400-CASP10

GeneCards

CASP10

ZINC - Substances

CASPA_HUMAN

ZINC target

Q92851

PRO

Q92851

Pharos - Targets

Q92851

Orphanet

CASP10

ZINC - Predictions - Purchasable

CASPA_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.75	4
UniProt:Q14790 CASP8	8	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(1-374) [cytosol] (R-HSA-3465404)	0.734	6
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.725	6
UniProt:O15519 CFLAR	1	CFLAR(1-376) [cytosol] (R-HSA-51925)	0.65	3
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.556	3