Reactome | CASP10(1-219) [cytosol]

CASP10(1-219) [cytosol]

Stable Identifier

R-HSA-933454

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casp-10 prodomain, Caspase-10 prodomain

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
      - Processing of caspases (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP10(1-219) [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP10(1-219) [cytosol] (Homo sapiens)
      - Recruitment of IKK complex (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        FADD:Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP10(1-219) [cytosol] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        FADD:Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        Casp-8/10 prodomain [cytosol] (Homo sapiens)
        
        CASP10(1-219) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92851 CASP10

Gene Names

CASP10, MCH4

Chain

propeptide:1-219, chain:220-415, chain:416-521

Reference Genes

BioGPS Gene:843 CASP10

COSMIC (genes):CASP10 CASP10

CTD Gene:843 CASP10

dbSNP Gene:843 CASP10

ENSEMBL:ENSG00000003400 CASP10

ENSEMBL:ENSG00000003400.16 CASP10

HGNC:1500 CASP10

KEGG Gene (Homo sapiens):843 CASP10

Monarch:843 CASP10

NCBI Gene:843 CASP10

OMIM:601762 CASP10

UCSC:Q92851 CASP10

Reference Transcript

Other Identifiers

11728056_a_at

11728057_a_at

11742104_a_at

11742105_at

11745653_a_at

1326_at

16889455

1765_at

1766_g_at

205467_PM_at

205467_at

210708_PM_x_at

210708_x_at

210955_PM_at

210955_at

211888_PM_x_at

211888_x_at

2522692

2522694

2522695

2522696

2522698

2522700

2522702

2522703

2522707

2522708

2522709

2522710

2522711

2522712

2522713

2522714

2522715

2522716

2522717

2522718

2522719

2522720

2522722

2522723

39999_at

8047403

83803_at

843

A_14_P138533

A_23_P209408

A_24_P139993

A_24_P3045

A_33_P3255075

A_33_P3504659

GE83594

GO:0002376

GO:0003824

GO:0004197

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0006915

GO:0006919

GO:0008233

GO:0008234

GO:0008625

GO:0012501

GO:0016787

GO:0023052

GO:0030154

GO:0030225

GO:0031265

GO:0031625

GO:0032991

GO:0035877

GO:0042981

GO:0043123

GO:0048856

GO:0051604

GO:0097153

GO:0097190

GO:0097199

GO:0097342

GO:0140096

HMNXSV003041002

HMNXSV003044062

HMNXSV003048182

ILMN_1797578

ILMN_2321720

PH_hs_0000550

TC02001176.hg

U60519_at

U86214_at

g1835778_3p_at

g4502568_3p_at

g4731236_3p_s_at

Participates

as a member of

Casp-8/10 prodomain [cytosol] (Homo sapiens)

Other forms of this molecule

CASP10(220-415) [cytosol]

CASP10(416-521) [cytosol]

CASP10(1-521) [cytosol]

Cross References

RefSeq

NP_001221.2, NP_001193471.1, NP_001193453.1, NP_116758.1, NP_001293012.1, NP_116759.2, NP_116756.2

Guide to Pharmacology - Targets

1626

OpenTargets

ENSG00000003400

ZINC - Substances

CASPA_HUMAN

ZINC target

Q92851

PRO

Q92851

IntEnz

3.4.22.63

GeneCards

Q92851

HPA

ENSG00000003400-CASP10

Ensembl

ENSP00000237865, ENSP00000512459, ENSP00000272879, ENSG00000003400, ENSP00000286186, ENSP00000363781, ENST00000313728, ENST00000492363, ENST00000374650, ENSP00000314599, ENST00000286186, ENST00000272879, ENST00000346817, ENST00000448480, ENSP00000396835

Pharos - Targets

Q92851

ZINC - Predictions - Purchasable

CASPA_HUMAN

Orphanet

15399

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.75	4
UniProt:Q14790 CASP8	8	CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.734	6
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.725	6
UniProt:O15519 CFLAR	1	CFLAR(1-376) [cytosol] (R-HSA-51925)	0.65	3
UniProt:P98170 XIAP	3	K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-50849)	0.556	3