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What is Reactome ?
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Table of Contents
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NOD2 [cytosol]
Stable Identifier
R-HSA-168411
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase recruitment domain protein 15
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
AAMP binds NOD2 (Homo sapiens)
AAMP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Activated NOD oligomer recruites RIP2 (RICK) (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Activated NOD2 oligomerizes (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
CARD9 binds RIP2 (and NOD2) (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:CARD9 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
CYLD deubiquitinates NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2:K63-pUb-K285-NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
MDP elicits a NOD2 response (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
RIP2 binds NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)
PAMP:NOD oligomer:RIP2:K63-pUb-K285-NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
RIP2 is K63 polyubiquitinated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 is activated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer [cytosol] (Homo sapiens)
MDP:NOD2 oligomer [cytosol] (Homo sapiens)
MDP:NOD2 [cytosol] (Homo sapiens)
NOD2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HC29 NOD2
Gene Names
NOD2, CARD15, IBD1
Chain
chain:1-1040
Reference Genes
BioGPS Gene:64127 NOD2
COSMIC (genes):NOD2 NOD2
CTD Gene:64127 NOD2
dbSNP Gene:64127 NOD2
ENSEMBL:ENSG00000167207 NOD2
HGNC:5331 NOD2
KEGG Gene (Homo sapiens):64127 NOD2
Monarch:64127 NOD2
NCBI Gene:64127 NOD2
OMIM:605956 NOD2
UCSC:Q9HC29 NOD2
Reference Transcript
RefSeq:NM_001293557.1 NOD2
RefSeq:XM_005256084.3 NOD2
RefSeq:NM_022162.2 NOD2
Other Identifiers
0005690048
11731340_at
11750212_a_at
16818820
220066_at
3660179
3660181
3660182
3660183
3660189
3660191
3660193
3660194
3660195
3660201
3660202
3660203
3660204
3660205
3660206
3660207
3660209
3660210
64127
75064_at
7995539
A_23_P420863
A_23_P77389
GE553808
GO:0000166
GO:0000187
GO:0002221
GO:0002367
GO:0002374
GO:0002376
GO:0002606
GO:0002732
GO:0002830
GO:0003674
GO:0003779
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0006464
GO:0006629
GO:0006810
GO:0006950
GO:0006952
GO:0007155
GO:0007165
GO:0007254
GO:0007267
GO:0007584
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009058
GO:0009595
GO:0009986
GO:0015031
GO:0016020
GO:0016045
GO:0016323
GO:0019899
GO:0019901
GO:0030277
GO:0030544
GO:0031410
GO:0031982
GO:0032495
GO:0032498
GO:0032500
GO:0032731
GO:0032733
GO:0032740
GO:0032755
GO:0032757
GO:0032760
GO:0032874
GO:0032991
GO:0034641
GO:0035556
GO:0038187
GO:0042592
GO:0042742
GO:0042834
GO:0042981
GO:0043123
GO:0043167
GO:0043226
GO:0043406
GO:0043552
GO:0044877
GO:0045087
GO:0045335
GO:0045747
GO:0045944
GO:0046330
GO:0046645
GO:0046658
GO:0050679
GO:0050700
GO:0050727
GO:0050871
GO:0051092
GO:0051353
GO:0051770
GO:0051879
GO:0060585
GO:0070374
GO:0070423
GO:0070431
GO:0070498
GO:0071222
GO:0071224
GO:0071225
GO:0071407
GO:1900017
GO:1901224
GO:1902523
GO:2000110
GO:2000363
ILMN_1762594
PH_hs_0008160
TC16000442.hg
TC16001548.hg
TC16001549.hg
g11545911_3p_at
Participant Of
hasComponent
AAMP:NOD2 [cytosol]
MDP:NOD2 [cytosol]
input
AAMP binds NOD2
MDP elicits a NOD2 response
Inferred To
nod2 [cytosol] (Danio rerio)
NOD2 [cytosol] (Canis familiaris)
Nod2 [cytosol] (Mus musculus)
Nod2 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_071445.1
,
XP_005256141.1
,
NP_001280486.1
OpenTargets
ENSG00000167207
GeneCards
Q9HC29
ZINC - Substances
NOD2_HUMAN
HPA
ENSG00000167207-NOD2
ZINC target
Q9HC29
Ensembl
ENSP00000495993
,
ENST00000647318
,
ENST00000300589
,
ENSG00000167207
,
ENSP00000300589
PRO
Q9HC29
ZINC - Predictions - Purchasable
NOD2_HUMAN
Orphanet
16556
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43353 RIPK2
2
Ub-209-RIPK2 [cytosol]
(R-HSA-706483)
RIPK2 [cytosol]
(R-HSA-168402)
0.734
4
UniProt:P08670 VIM
11
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.725
7
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.664
10
UniProt:Q96RT1 ERBIN
1
ERBIN [plasma membrane]
(R-HSA-1358718)
0.664
5
UniProt:P29466 CASP1
5
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(1-404) [cytosol]
(R-HSA-448692)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
0.591
4
UniProt:Q96RT1-2 ERBIN
0.581
5
UniProt:Q9P0J0 NDUFA13
1
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
0.543
6
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.527
2
UniProt:Q04724 TLE1
2
TLE1 [nucleoplasm]
(R-HSA-212327)
Ub-TLE1 [nucleoplasm]
(R-HSA-3322369)
0.508
2
UniProt:Q9Y3D6 FIS1
2
FIS1 [cytosol]
(R-HSA-9033099)
FIS1 [peroxisomal membrane]
(R-HSA-9033123)
0.508
2
UniProt:Q10471 GALNT2
2
GALNT2(1-571) [Golgi membrane]
(R-HSA-913618)
GALNT2(1-571) [endoplasmic reticulum membrane]
(R-HSA-8849322)
0.508
2
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.508
2
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.508
2
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