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CASP7(2-303) [cytosol]
Stable Identifier
R-HSA-57029
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase-7 precursor , ICE-like apoptotic protease 3, ICE-LAP3, Apoptotic protease Mch-3, CMH-1
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)
CASP7(2-303) dimer [cytosol] (Homo sapiens)
CASP7(2-303) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55210 CASP7
Gene Names
CASP7, MCH3
Chain
initiator methionine:, propeptide:2-23, chain:24-198, propeptide:199-206, chain:207-303
Reference Genes
BioGPS Gene:840 CASP7
COSMIC (genes):CASP7 CASP7
CTD Gene:840 CASP7
dbSNP Gene:840 CASP7
ENSEMBL:ENSG00000165806 CASP7
ENSEMBL_homo_sapiens_GENE:ENSG00000165806.21 CASP7
HGNC:1508 CASP7
KEGG Gene (Homo sapiens):840 CASP7
Monarch:840 CASP7
NCBI Gene:840 CASP7
OMIM:601761 CASP7
UCSC:P55210 CASP7
Reference Transcript
RefSeq:NM_001267056.1 CASP7
RefSeq:NM_033339.4 CASP7
RefSeq:NM_001227.4 CASP7
RefSeq:NM_001267058.1 CASP7
RefSeq:NM_001267057.1 CASP7
RefSeq:NM_033338.5 CASP7
RefSeq:NM_001320911.1 CASP7
RefSeq:NM_033340.3 CASP7
Other Identifiers
11719647_a_at
11719648_a_at
11728226_a_at
11750198_a_at
16709386
207181_PM_s_at
207181_s_at
3264950
3264951
3264952
3264953
3264954
3264956
3264957
3264959
3264978
3264979
3264980
3264981
3264982
3264984
3264986
3264987
3264988
3264989
3264991
38281_at
7930577
840
A_14_P117796
A_23_P12572
GE59348
GO:0003723
GO:0003824
GO:0004190
GO:0004197
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006508
GO:0006915
GO:0007507
GO:0008152
GO:0008233
GO:0008234
GO:0009411
GO:0012501
GO:0016485
GO:0016787
GO:0030154
GO:0030163
GO:0042060
GO:0042742
GO:0043226
GO:0044346
GO:0048856
GO:0051146
GO:0051402
GO:0051604
GO:0051716
GO:0061024
GO:0070227
GO:0071222
GO:0071887
GO:0072734
GO:0097153
GO:0097194
GO:0097200
GO:0098542
GO:0140096
GO:1905686
HMNXSV003037170
ILMN_1730332
ILMN_2362974
ILMN_2373763
PH_hs_0000966
TC10000825.hg
U67319_at
g4502580_3p_a_at
Participates
as a component of
CASP7(2-303) dimer [cytosol] (Homo sapiens)
Other forms of this molecule
CASP7(24-198) [nucleoplasm]
CASP7(207-303) [nucleoplasm]
CASP7(24-198) [cytosol]
CASP7(207-303) [cytosol]
Inferred To
casp7 [cytosol]
(Danio rerio)
casp7 [cytosol]
(Xenopus tropicalis)
Casp7 [cytosol]
(Mus musculus)
Casp7 [cytosol]
(Rattus norvegicus)
CASP7 [cytosol]
(Bos taurus)
CASP7 [cytosol]
(Canis familiaris)
CASP7 [cytosol]
(Gallus gallus)
CASP7 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001218.1
,
NP_001253987.1
,
NP_203125.1
,
NP_203126.1
,
NP_203124.1
,
NP_001307840.1
,
NP_001253985.1
,
NP_001253986.1
Guide to Pharmacology - Targets
1623
OpenTargets
ENSG00000165806
ZINC - Substances
CASP7_HUMAN
ZINC target
P55210
PRO
P55210
PDB
1GQF
,
4ZVO
,
5K20
,
1K86
,
5V6Z
,
2QL7
,
4HQR
,
5V6U
,
2QL5
,
1KMC
,
4ZVU
,
2QLJ
,
1SHL
,
4ZVT
,
1SHJ
,
4FEA
,
2QLF
,
1F1J
,
8DGZ
,
4ZVS
,
3R5K
,
3IBF
,
1I51
,
8DJ3
,
4LSZ
,
2QLB
,
7WZS
,
4JB8
,
4ZVR
,
5IC6
,
4JJ8
,
1I4O
,
3EDR
,
4ZVQ
,
3H1P
,
2QL9
,
4HQ0
,
4FDL
,
4JR2
,
3IBC
,
4JR1
,
1K88
,
4ZVP
ZINC - Investigational
CASP7_HUMAN
HPA
ENSG00000165806-CASP7
GeneCards
P55210
Ensembl
ENSP00000358324
,
ENSP00000478999
,
ENSP00000358321
,
ENST00000452490
,
ENST00000369331
,
ENSP00000298701
,
ENSP00000478285
,
ENSP00000398107
,
ENST00000614447
,
ENSG00000165806
,
ENST00000621345
,
ENST00000369315
,
ENSP00000480584
,
ENST00000345633
,
ENST00000369318
,
ENSP00000358337
,
ENST00000621607
Pharos - Targets
P55210
ZINC - Predictions - Purchasable
CASP7_HUMAN
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.836
6
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.718
6
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.641
3
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.619
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
UniProt:P17405 SMPD1
1
SMPD1 [lysosomal lumen]
(R-HSA-1605710)
0.537
6
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.508
2
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