Reactome | glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]

glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-5172994

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

O-fuc-ADAMTS4, ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4, ATS4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75173 ADAMTS4

Gene Names

ADAMTS4, KIAA0688, UNQ769/PRO1563

Chain

signal peptide:1-51, propeptide:52-212, chain:213-837

Reference Genes

BioGPS Gene:9507 ADAMTS4

COSMIC (genes):ADAMTS4 ADAMTS4

CTD Gene:9507 ADAMTS4

dbSNP Gene:9507 ADAMTS4

ENSEMBL:ENSG00000158859 ADAMTS4

HGNC:220 ADAMTS4

KEGG:hsa:9507 ADAMTS4

Monarch:9507 ADAMTS4

NCBI Gene:9507 ADAMTS4

OMIM:603876 ADAMTS4

UCSC:O75173 ADAMTS4

Reference Transcript

Other Identifiers

11730923_x_at

11752079_x_at

1555380_PM_at

1555380_at

16695627

238312_PM_s_at

238312_s_at

2440696

2440697

2440698

2440699

2440701

2440702

2440703

2440704

2440705

2440706

2440707

2440708

2440709

2440710

2440711

2440712

2440713

2440714

2440715

2440716

2440717

2440718

2440722

2440723

2440724

7921821

83744_at

9507

A_23_P360754

A_24_P128163

GE532164

GE578983

GE61341

GO:0001501

GO:0002020

GO:0004222

GO:0005515

GO:0005576

GO:0005615

GO:0006508

GO:0008233

GO:0008237

GO:0008270

GO:0016020

GO:0016607

GO:0016787

GO:0022617

GO:0030163

GO:0030167

GO:0030198

GO:0030312

GO:0031012

GO:0042742

GO:0046872

GO:0048856

GO:0098542

GO:1901135

HMNXSV003000983

HMNXSV003012327

HMNXSV003048563

Hs.157267.1.A1_3p_at

Hs2.211604.2.S1_3p_at

Hs2.211604.2.S1_3p_x_at

ILMN_2092933

PH_hs_0009855

PH_hs_0012277

TC01003421.hg

Participates

as a candidate of

glc-fuc-proteins [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

ADAMTS4 [extracellular region]

ADAMTS4 [endoplasmic reticulum lumen]

O-fuc-ADAMTS4 [endoplasmic reticulum lumen]

Inferred To

rsc22 [endoplasmic reticulum lumen] (Dictyostelium discoideum)

ADAMTS4 [endoplasmic reticulum lumen] (Bos taurus)

ADAMTS4 [endoplasmic reticulum lumen] (Gallus gallus)

ADAMTS4 [endoplasmic reticulum lumen] (Sus scrofa)

glc-fuc-ADAMTS4 [endoplasmic reticulum lumen] (Canis familiaris)

AdamTS-A [endoplasmic reticulum lumen] (Drosophila melanogaster)

adamts4 [endoplasmic reticulum lumen] (Xenopus tropicalis)

gon-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Adamts4 [endoplasmic reticulum lumen] (Mus musculus)

Adamts4 [endoplasmic reticulum lumen] (Rattus norvegicus)

Modified Residues

Name

O-fucosyl-L-serine (ChEBI:76521) at unknown position

Modification

beta-D-glucosyl-(1->3)-alpha-L-fucosyl group

PsiMod Name

O-fucosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to an O-fucosylserine.

Cross References

RefSeq

NP_001307265.1, NP_005090.3

Guide to Pharmacology - Targets

1677

ENSEMBL

ENSP00000356975, ENST00000367996, ENSG00000158859

OpenTargets

ENSG00000158859

GeneCards

ADAMTS4

HPA

ENSG00000158859-ADAMTS4

ZINC - Substances

ATS4_HUMAN

ZINC target

O75173

PRO

O75173

Pharos - Targets

O75173

ZINC - Predictions - Purchasable

ATS4_HUMAN

PDB

3B2Z, 2RJP, 4WK7, 4WKI, 4WKE

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	3
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.527	2
UniProt:O00462 MANBA	3	MANBA [plasma membrane] (R-HSA-6806257) MANBA [azurophil granule membrane] (R-HSA-6799128) MANBA [lysosomal lumen] (R-HSA-8853711)	0.527	2
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.527	3
UniProt:Q7L8W6 DPH6	1	DPH6 [cytosol] (R-HSA-5358469)	0.527	2