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glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-5172994
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
O-fuc-ADAMTS4, ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4, ATS4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
O-linked glycosylation (Homo sapiens)
O-glycosylation of TSR domain-containing proteins (Homo sapiens)
B3GALTL transfers glucose to O-fucosyl-proteins (Homo sapiens)
glc-fuc-proteins [endoplasmic reticulum lumen] (Homo sapiens)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75173 ADAMTS4
Gene Names
ADAMTS4, KIAA0688, UNQ769/PRO1563
Chain
signal peptide:1-51, propeptide:52-212, chain:213-837
Reference Genes
BioGPS Gene:9507 ADAMTS4
COSMIC (genes):ADAMTS4 ADAMTS4
CTD Gene:9507 ADAMTS4
dbSNP Gene:9507 ADAMTS4
ENSEMBL:ENSG00000158859 ADAMTS4
ENSEMBL_homo_sapiens_GENE:ENSG00000158859.10 ADAMTS4
HGNC:220 ADAMTS4
KEGG Gene (Homo sapiens):9507 ADAMTS4
Monarch:9507 ADAMTS4
NCBI Gene:9507 ADAMTS4
OMIM:603876 ADAMTS4
UCSC:O75173 ADAMTS4
Reference Transcript
RefSeq:NM_005099.5 ADAMTS4
RefSeq:NM_001320336.1 ADAMTS4
Other Identifiers
11730923_x_at
11752079_x_at
16695627
238312_PM_s_at
238312_s_at
2440696
2440697
2440698
2440699
2440701
2440702
2440703
2440704
2440705
2440706
2440707
2440708
2440709
2440710
2440711
2440714
2440718
2440722
2440723
2440724
7921821
83744_at
9507
A_23_P360754
GE532164
GE578983
GE61341
GO:0001501
GO:0002020
GO:0003824
GO:0004222
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0006508
GO:0008233
GO:0008237
GO:0008270
GO:0016607
GO:0016787
GO:0022617
GO:0030198
GO:0030312
GO:0031012
GO:0043226
GO:0046872
GO:0048856
GO:0062023
GO:0140096
HMNXSV003012327
HMNXSV003048563
Hs.157267.1.A1_3p_at
ILMN_2092933
PH_hs_0009855
PH_hs_0012277
TC01003421.hg
Participates
as a candidate of
glc-fuc-proteins [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
ADAMTS4 [extracellular region]
ADAMTS4 [endoplasmic reticulum lumen]
O-fuc-ADAMTS4 [endoplasmic reticulum lumen]
Inferred To
rsc22 [endoplasmic reticulum lumen]
(Dictyostelium discoideum)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Bos taurus)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Canis familiaris)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Gallus gallus)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Mus musculus)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Rattus norvegicus)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Sus scrofa)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Homologues of glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Modified Residues
Name
O-fucosyl-L-serine (ChEBI:76521) at unknown position
Modification
beta-D-glucosyl-(1->3)-alpha-L-fucosyl group
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Cross References
RefSeq
NP_005090.3
,
NP_001307265.1
Guide to Pharmacology - Targets
1677
OpenTargets
ENSG00000158859
ZINC - Substances
ATS4_HUMAN
HPA
ENSG00000158859-ADAMTS4
GeneCards
O75173
Ensembl
ENSG00000158859
,
ENSP00000356975
,
ENST00000367996
ZINC target
O75173
PRO
O75173
Pharos - Targets
O75173
ZINC - Predictions - Purchasable
ATS4_HUMAN
PDB
2RJP
,
4WKI
,
4WK7
,
4WKE
,
3B2Z
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7L8W6 DPH6
1
DPH6 [cytosol]
(R-HSA-5358469)
0.527
2
UniProt:O00462 MANBA
3
MANBA [plasma membrane]
(R-HSA-6806257)
MANBA [azurophil granule membrane]
(R-HSA-6799128)
MANBA [lysosomal lumen]
(R-HSA-8853711)
0.527
2
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.527
2
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.527
3
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.527
3
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