Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Ub-209-RIPK2 [cytosol]
Stable Identifier
R-HSA-706483
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63-Ub-RIP2, RICK, receptor-interacting serine-threonine kinase 2
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
RIP2 is K63 polyubiquitinated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1 is activated (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Homo sapiens)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Ub-209-RIPK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43353 RIPK2
Gene Names
RIPK2, RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092
Chain
chain:1-540
Reference Genes
BioGPS Gene:8767 RIPK2
COSMIC (genes):RIPK2 RIPK2
CTD Gene:8767 RIPK2
dbSNP Gene:8767 RIPK2
ENSEMBL:ENSG00000104312 RIPK2
ENSEMBL_homo_sapiens_GENE:ENSG00000104312.8 RIPK2
HGNC:10020 RIPK2
KEGG Gene (Homo sapiens):8767 RIPK2
Monarch:8767 RIPK2
NCBI Gene:8767 RIPK2
OMIM:603455 RIPK2
UCSC:O43353 RIPK2
Reference Transcript
RefSeq:NM_003821.5 RIPK2
RefSeq:XM_005251092.3 RIPK2
Other Identifiers
11724236_a_at
11758901_at
17070634
209544_PM_at
209544_at
209545_PM_s_at
209545_s_at
3106244
3106245
3106246
3106247
3106248
3106249
3106250
3106251
3106252
3106254
3106257
3106258
3106260
3106261
3106262
3106263
3106264
3106265
3106266
41384_at
8147206
8767
A_14_P112304
A_14_P202266
A_23_P252106
A_24_P124032
GE54827
GO:0000166
GO:0001961
GO:0002250
GO:0002376
GO:0002827
GO:0003824
GO:0004672
GO:0004674
GO:0004706
GO:0004713
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005737
GO:0005783
GO:0005829
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006914
GO:0006915
GO:0006950
GO:0006954
GO:0007155
GO:0007165
GO:0007249
GO:0007254
GO:0008152
GO:0010800
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0023052
GO:0030154
GO:0030274
GO:0031349
GO:0031398
GO:0031663
GO:0031982
GO:0032092
GO:0032103
GO:0032722
GO:0032727
GO:0032728
GO:0032729
GO:0032731
GO:0032735
GO:0032743
GO:0032755
GO:0032760
GO:0032874
GO:0032991
GO:0033080
GO:0033092
GO:0033138
GO:0034134
GO:0034142
GO:0035591
GO:0035739
GO:0036211
GO:0042098
GO:0042742
GO:0042802
GO:0042803
GO:0042981
GO:0043065
GO:0043123
GO:0043226
GO:0043330
GO:0045087
GO:0045627
GO:0045944
GO:0046330
GO:0048856
GO:0050700
GO:0050731
GO:0050830
GO:0050852
GO:0051092
GO:0051260
GO:0051403
GO:0051604
GO:0060090
GO:0060907
GO:0065003
GO:0070371
GO:0070374
GO:0070427
GO:0070431
GO:0070555
GO:0070671
GO:0070673
GO:0071222
GO:0071223
GO:0071224
GO:0071225
GO:0071310
GO:0089720
GO:0097202
GO:0098542
GO:0098792
GO:0106310
GO:0140096
GO:1902523
GO:1904417
GO:2000563
HMNXSV003009409
ILMN_1758939
PH_hs_0005753
TC08000545.hg
TC08002008.hg
g3123886_3p_at
g3123886_3p_x_at
g3290171_3p_a_at
Participates
as a component of
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Homo sapiens)
Other forms of this molecule
RIPK2 [cytosol]
Inferred To
Ripk2 [cytosol]
(Rattus norvegicus)
RIPK2 [cytosol]
(Canis familiaris)
Ub-209-RIPK2 [cytosol]
(Bos taurus)
Ub-209-RIPK2 [cytosol]
(Danio rerio)
Ub-209-RIPK2 [cytosol]
(Mus musculus)
Ub-209-RIPK2 [cytosol]
(Sus scrofa)
ripk2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at 209
Coordinate
209
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005251149.1
,
NP_003812.1
ZINC - World Drugs
RIPK2_HUMAN
Guide to Pharmacology - Targets
2190
OpenTargets
ENSG00000104312
ZINC - FDA approved
RIPK2_HUMAN
ZINC - Substances
RIPK2_HUMAN
ZINC target
O43353
ZINC - Biogenic
RIPK2_HUMAN
PRO
O43353
PDB
6HMX
,
2N83
,
6ES0
,
6FU5
,
5AR8
,
7OBT
,
6GGS
,
5AR5
,
7OBS
,
6UL8
,
5AR7
,
5YRN
,
6SZJ
,
6S1F
,
8AZA
,
5AR3
,
5AR4
,
5NG3
,
5J7B
,
6SZE
,
5W5O
,
6RNA
,
2N7Z
,
4C8B
,
6RN8
,
5NG0
,
5AR2
,
5NG2
,
5J79
,
6GFJ
,
5W5J
ZINC - Investigational
RIPK2_HUMAN
HPA
ENSG00000104312-RIPK2
GeneCards
O43353
Ensembl
ENST00000220751
,
ENSG00000104312
,
ENSP00000220751
Pharos - Targets
O43353
ZINC - Predictions - Purchasable
RIPK2_HUMAN
HMDB Protein
HMDBP01505
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.951
22
UniProt:Q9HC29 NOD2
1
NOD2 [cytosol]
(R-HSA-168411)
0.8
6
UniProt:Q9Y239 NOD1
1
NOD1 [cytosol]
(R-HSA-168407)
0.762
6
UniProt:O43353 RIPK2
2
RIPK2 [cytosol]
(R-HSA-168402)
Ub-209-RIPK2 [cytosol]
(R-HSA-706483)
0.749
7
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.72
6
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.688
3
UniProt:Q13489 BIRC3
3
BIRC3 [cytosol]
(R-HSA-50845)
K48pUb-BIRC3 [cytosol]
(R-HSA-5675478)
K63polyUb-BIRC3 [cytosol]
(R-HSA-5668478)
0.602
3
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.602
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.576
3
UniProt:Q9BVT8 TMUB1
0.527
2
UniProt:Q5VV17 OTUD1
1
OTUD1 [cytosol]
(R-HSA-9816081)
0.463
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text