Reactome | SIAH1 [cytosol]

SIAH1 [cytosol]

Stable Identifier

R-HSA-374563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase SIAH1, SIAH1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8IUQ4 SIAH1

Gene Names

SIAH1, HUMSIAH

Chain

chain:1-282

Reference Genes

BioGPS Gene:6477 SIAH1

COSMIC (genes):SIAH1 SIAH1

CTD Gene:6477 SIAH1

dbSNP Gene:6477 SIAH1

ENSEMBL:ENSG00000196470 SIAH1

HGNC:10857 SIAH1

KEGG Gene (Homo sapiens):6477 SIAH1

Monarch:6477 SIAH1

NCBI Gene:6477 SIAH1

OMIM:602212 SIAH1

UCSC:Q8IUQ4 SIAH1

Reference Transcript

Other Identifiers

0005720184

0102060280

11739661_a_at

11739662_x_at

11744928_x_at

11749340_s_at

11752177_a_at

16826356

18724

202980_s_at

202981_x_at

232365_3p_at

232365_at

2A25

32160_at

3690551

3690552

3690553

3690554

3690555

3690556

3690557

3690558

3690559

3690560

3690561

3690562

3690563

3690566

3690580

3690581

3690582

3690583

4C9Z

4CA1

4I7B

4I7C

4I7D

4X3G

5WZZ

6477

8001306

87291_at

A_23_P106798

A_33_P3270509

AAC12950

AAC51907

AAH35562

AAH42550

AAH44920

ABK15529

AJ400626

BC035562

BC042550

BC044920

BX647064

CAB018724

CAC35542

CAE46191

CCDS10735

CCDS32444

EF026094

ENSG00000196470

ENSP00000349156

ENSP00000369343

ENSP00000378214

ENSP00000456421

ENST00000356721

ENST00000356721.3

ENST00000380006

ENST00000380006.2

ENST00000394725

ENST00000394725.2

ENST00000568007

ENST00000568007.5

EntrezGene:6477

EntrezGene:SIAH1

g4506946_3p_at

g4506946_3p_x_at

GE81225

GO:0000003

GO:0000209

GO:0000902

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006464

GO:0006511

GO:0006915

GO:0007049

GO:0007165

GO:0007275

GO:0007283

GO:0007399

GO:0007411

GO:0008022

GO:0008150

GO:0008219

GO:0008270

GO:0009056

GO:0009653

GO:0016567

GO:0016740

GO:0019899

GO:0030154

GO:0030163

GO:0030877

GO:0031410

GO:0031624

GO:0031648

GO:0032991

GO:0040011

GO:0042802

GO:0043065

GO:0043161

GO:0043167

GO:0043226

GO:0044267

GO:0046872

GO:0048856

GO:0051402

GO:0061630

GO:1902842

GO:2001244

H3BU09

HGNC:10857

Hs.188990.0.S1_3p_x_at

Hs.295923.0.S1_3p_a_at

ILMN_1661161

ILMN_1711627

ILMN_1802261

ILMN_1888224

ILMN_2279413

ILMN_2380566

IPR001841

IPR004162

IPR008974

IPR013010

IPR013083

IPR018121

MIM:602212

NM_001006610

NM_003031

NP_001006611

NP_003022

PF03145

PH_hs_0015319

SIAH1

SIAH1-201

SIAH1-202

SIAH1-203

SIAH1-207

TC16001095.hg

U63295

U76247

UPI0000073CF6

UPI0000074729

XM_006721246

XM_011523279

XM_024450394

XM_024450395

XP_006721309

XP_011521581

XP_024306162

XP_024306163

Participant Of

hasMember

output

Ub-SNCA dissociates from the conjugating enzyme

hasComponent

input

DCC interaction with SIAH1

Inferred To

Homologues of SIAH1 [cytosol] (Drosophila melanogaster)

SIAH1 [cytosol] (Bos taurus)

SIAH1 [cytosol] (Caenorhabditis elegans)

SIAH1 [cytosol] (Canis familiaris)

SIAH1 [cytosol] (Danio rerio)

SIAH1 [cytosol] (Drosophila melanogaster)

SIAH1 [cytosol] (Gallus gallus)

SIAH1 [cytosol] (Mus musculus)

SIAH1 [cytosol] (Rattus norvegicus)

SIAH1 [cytosol] (Sus scrofa)

SIAH1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_006721309.1, NP_001006611.1, NP_003022.3, XP_011521581.1

OpenTargets

ENSG00000196470

IntEnz

2.3.2.27

GeneCards

Q8IUQ4

PRO

Q8IUQ4

PDB

4I7C, 4CA1, 4I7B, 4C9Z, 4I7D, 5WZZ, 2A25, 4X3G

HMDB Protein

HMDBP09307

Interactors (94)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.742	7
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.742	5
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.668	3
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.666	4
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.666	4
UniProt:Q9HB71 CYBP			0.658	3
UniProt:Q64693 OBF1			0.626	5
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.581	4
UniProt:P69713 X			0.571	4
UniProt:P86479 PR20C			0.556	5
UniProt:Q8WW36 ZCH13			0.556	3
UniProt:Q86TG7 PEG10			0.556	3
UniProt:P05111 INHA	1	INHA [extracellular region] (R-HSA-1449702)	0.556	3
UniProt:Q59GP6 Q59GP6			0.556	3
UniProt:Q9C029 TRIM7			0.556	3
UniProt:Q9BW62 KATL1			0.556	3
UniProt:Q9BQ24 ZFY21			0.556	3
UniProt:Q8TBK6 ZCH10			0.556	3
IntAct:EBI-10261370 6157			0.556	3
UniProt:Q8N619 Q8N619			0.556	3
UniProt:ZNF671 A0A0C4DH15			0.556	3
UniProt:Q8TAN2 Q8TAN2			0.556	3
UniProt:Q9UQR1 ZN148			0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:Q14088 RAB33A	3	GGC-RAB33A [cytosol] (R-HSA-8873981) RAB33A [Golgi membrane] (R-HSA-8854592) RAB33A [cytosol] (R-HSA-8873704)	0.556	3
UniProt:Q9Y4B4 ARIP4			0.556	3
UniProt:Q13394 MB211			0.556	3
UniProt:Q53H82 LACB2			0.556	3
UniProt:Q9BTV4 TMM43			0.556	3
UniProt:P40121 CAPG			0.556	3
UniProt:Q9UHB7-2 AFF4			0.556	5
UniProt:Q9H6R4-4 NOL6			0.556	3
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.556	3
UniProt:Q8NEY3 SPAT4			0.556	3
UniProt:Q6FIE9 Q6FIE9			0.556	3
UniProt:O43581 SYT7	1	SYT7 [synaptic vesicle membrane] (R-HSA-6789228)	0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q9Y5T4 DJC15			0.556	3
UniProt:Q8N2X6 EXAS1			0.556	3
UniProt:O60336 MABP1			0.556	3
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.556	5
UniProt:O95045 UPP2	1	UPP2 [cytosol] (R-HSA-977410)	0.556	3
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.556	3
UniProt:Q5T5P2-6 KIAA1217			0.556	3
UniProt:Q8IZA0 K319L			0.556	3
UniProt:P11216 PYGB	4	PXLP-PYGB [azurophil granule lumen] (R-HSA-6799164) PXLP-PYGB [extracellular region] (R-HSA-6801536) PXLP-p-S14-PYGB [cytosol] (R-HSA-71868) PXLP-PYGB [cytosol] (R-HSA-71862)	0.556	3
UniProt:P78508 KCNJ10	1	KCNJ10 [plasma membrane] (R-HSA-975290)	0.556	3
UniProt:P49427 CDC34	4	Ub-C93-CDC34 [nucleoplasm] (R-HSA-8864204) Ub-C93-CDC34 [cytosol] (R-HSA-8864170) CDC34 [nucleoplasm] (R-HSA-8852125) CDC34 [cytosol] (R-HSA-947621)	0.556	3
UniProt:P29972 AQP1	1	AQP1 [plasma membrane] (R-HSA-431700)	0.556	3
UniProt:Q70IA8 MOB3C			0.556	3
UniProt:Q9UJV9 DDX41	3	K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941) DDX41 [cytosol] (R-HSA-3134807)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:O60333 KIF1B	1	KIF1B [cytosol] (R-HSA-8849378)	0.556	3
UniProt:P08237 PFKM	1	PFKM [cytosol] (R-HSA-70460)	0.556	3
UniProt:Q9H0A9 SPC1L			0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q9NU19 TB22B			0.556	3
UniProt:Q96DC9 OTUB2	2	OTUB2 [nucleoplasm] (R-HSA-6783260) OTUB2 [cytosol] (R-HSA-933410)	0.556	3
UniProt:Q96KM6 Z512B			0.556	3
UniProt:Q9NVL8 CC198			0.556	3
UniProt:A2RRL9 A2RRL9			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q2TAL8 QRIC1			0.556	3
UniProt:Q9H0B3 IQCN			0.556	3
UniProt:P20591 MX1	1	MX1 [cytosol] (R-HSA-947489)	0.556	3
UniProt:Q7Z3E5-2 ARMC9			0.556	3
UniProt:Q8TAM4 Q8TAM4			0.556	3
UniProt:Q96B01-2 RAD51AP1			0.556	3
UniProt:P53778 MAPK12	3	p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021) MAPK12 [nucleoplasm] (R-HSA-448833) MAPK12 [cytosol] (R-HSA-171025)	0.556	3
UniProt:Q9HA38 ZMAT3			0.556	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q01543 FLI1	1	FLI1 [nucleoplasm] (R-HSA-9616216)	0.556	3
UniProt:Q9NRN7 AASDHPPT	1	AASDHPPT [cytosol] (R-HSA-199235)	0.556	3
UniProt:Q8WUK0 PTPMT1	1	PTPMT1 [mitochondrial inner membrane] (R-HSA-3446802)	0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.556	3
UniProt:Q86WX3 RPS19BP1	1	RPS19BP1 [nucleoplasm] (R-HSA-3371427)	0.556	3
UniProt:Q96B01 RAD51AP1	1	RAD51AP1 [nucleoplasm] (R-HSA-5685301)	0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.556	3
UniProt:Q92692 NECTIN2	1	PVRL2 [plasma membrane] (R-HSA-419006)	0.556	3
UniProt:P61077 UBE2D3	3	UBE2D3 [nucleoplasm] (R-HSA-205341) Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [cytosol] (R-HSA-934630)	0.553	2
UniProt:P54259 ATN1	1	ATN1 [nucleoplasm] (R-HSA-6807083)	0.553	2
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628)	0.553	2
UniProt:Q69ZI1	1	SH3RF1 [cytosol] (R-MMU-5688968)	0.544	5
UniProt:Q99836 MYD88	9	MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-193946) MYD88 [cytosol] (R-HSA-166059) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329)	0.543	3
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.524	3
UniProt:O15265 ATXN7	2	ATXN7 [cytosol] (R-HSA-201591) ATXN7 [nucleoplasm] (R-HSA-8869458)	0.508	2
UniProt:Q15599 NHRF2			0.508	2
UniProt:Q16633 OBF1			0.508	2