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MAPK14 [nucleoplasm]
Stable Identifier
R-HSA-446223
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MAP kinase p38 alpha, Mitogen-activated protein kinase 14, MK14_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)
p38 MAPK:MAPKAPK5 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
MAPK14 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16539 MAPK14
Gene Names
MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Chain
initiator methionine:1, chain:2-360
Reference Genes
COSMIC (genes):MAPK14 MAPK14
dbSNP Gene:1432 MAPK14
ENSEMBL:ENSG00000112062 MAPK14
Participates
as a member of
MAP kinase p38 alpha/beta [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T180,Y182-MAPK14 [nucleoplasm]
p-T180,Y182-MAPK14 [cytosol]
MAPK14 [cytosol]
MAPK14 [secretory granule lumen]
MAPK14 [extracellular region]
MAPK14 [ficolin-1-rich granule lumen]
Inferred To
MAPK14 [nucleoplasm]
(Bos taurus)
MAPK14 [nucleoplasm]
(Caenorhabditis elegans)
MAPK14 [nucleoplasm]
(Danio rerio)
MAPK14 [nucleoplasm]
(Drosophila melanogaster)
MAPK14 [nucleoplasm]
(Gallus gallus)
MAPK14 [nucleoplasm]
(Mus musculus)
MAPK14 [nucleoplasm]
(Rattus norvegicus)
MAPK14 [nucleoplasm]
(Sus scrofa)
Homologues of MAPK14 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of MAPK14 [nucleoplasm]
(Drosophila melanogaster)
gskl-2 [nucleoplasm]
(Caenorhabditis elegans)
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.936
16
UniProt:Q16644 MAPKAPK3
4
MAPKAPK3 [nucleoplasm]
(R-HSA-450218)
p-S,2T-MAPKAPK3 [nucleoplasm]
(R-HSA-450359)
p-S,2T-MAPKAPK3 [cytosol]
(R-HSA-187723)
MAPKAPK3 [cytosol]
(R-HSA-187764)
0.922
16
UniProt:O75676 RPS6KA4
1
RPS6KA4 [cytosol]
(R-HSA-772527)
0.869
10
UniProt:P46734 MAP2K3
3
MAP2K3 [cytosol]
(R-HSA-168051)
p-S218,T222-MAP2K3 [cytosol]
(R-HSA-167955)
p-S218,T222-MAP2K3 [nucleoplasm]
(R-HSA-450229)
0.802
7
UniProt:Q9BUB5 MKNK1
1
p-T250,T255,T385,S437-MKNK1 [cytosol]
(R-HSA-947860)
0.798
7
UniProt:O75147 OBSL1
1
OBSL1 [cytosol]
(R-HSA-8955929)
0.788
5
UniProt:Q9HBH9 MKNK2
0.788
5
UniProt:Q99956 DUSP9
1
DUSP9 [cytosol]
(R-HSA-5675351)
0.779
6
UniProt:P28562 DUSP1
1
DUSP1 [nucleoplasm]
(R-HSA-203796)
0.767
4
UniProt:Q8NEM7 SUPT20H
1
SUPT20H [nucleoplasm]
(R-HSA-3662286)
0.756
5
UniProt:Q9BY84 DUSP16
3
DUSP16 [cytosol]
(R-HSA-5675336)
DUSP16 [nucleoplasm]
(R-HSA-5675337)
Ac-55-DUSP16 [cytosol]
(R-HSA-9636576)
0.738
4
UniProt:O43257 ZNHI1
0.72
7
UniProt:Q15750 TAB1
6
TAB1 [cytosol]
(R-HSA-167923)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(445-504) [cytosol]
(R-HSA-9729691)
0.713
4
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.691
5
UniProt:Q15256 PTPRR
0.664
4
UniProt:O75582 RPS6KA5
3
p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
(R-HSA-198683)
RPS6KA5 [nucleoplasm]
(R-HSA-198657)
RPS6KA5 [cytosol]
(R-HSA-772525)
0.659
4
UniProt:Q6PJG2 MDEAS
0.659
3
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.643
4
UniProt:Q9H0W5 CCDC8
1
CCDC8 [cytosol]
(R-HSA-8955915)
0.643
3
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.623
4
UniProt:Q16829 DUSP7
2
DUSP7 [cytosol]
(R-HSA-5675346)
DUSP7 [nucleoplasm]
(R-HSA-203791)
0.59
2
UniProt:P52564 MAP2K6
3
MAP2K6 [cytosol]
(R-HSA-167998)
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
0.564
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q9H869 YYAP1
0.553
2
UniProt:Q8IW41 MAPKAPK5
5
p-T182 MAPKAPK5 [cytosol]
(R-HSA-5687004)
p-S115 MAPKAPK5 [cytosol]
(R-HSA-5687028)
p-S115 MAPKAPK5 [nucleoplasm]
(R-HSA-5687026)
p-T182-MAPKAPK5 [nucleoplasm]
(R-HSA-3239018)
MAPKAPK5 [nucleoplasm]
(R-HSA-2562517)
0.547
2
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.547
3
UniProt:Q14814 MEF2D
1
MEF2D [nucleoplasm]
(R-HSA-445328)
0.547
2
UniProt:Q15759 MAPK11
4
p-T180,Y182-MAPK11 [nucleoplasm]
(R-HSA-198741)
MAPK11 [nucleoplasm]
(R-HSA-203790)
MAPK11 [cytosol]
(R-HSA-170989)
p-T180,Y182-MAPK11 [cytosol]
(R-HSA-171009)
0.547
2
UniProt:Q5VYV7 SLX4I
0.527
3
UniProt:P51784 USP11
1
USP11 [cytosol]
(R-HSA-391303)
0.527
2
UniProt:Q96RR4 CAMKK2
4
p-CAMKK2 [nucleoplasm]
(R-HSA-9618968)
CAMKK2 [nucleoplasm]
(R-HSA-5336483)
p-CAMKK2 [cytosol]
(R-HSA-9619358)
CAMKK2 [cytosol]
(R-HSA-9619231)
0.527
2
UniProt:Q14999 CUL7
1
CUL7 [cytosol]
(R-HSA-535534)
0.527
2
UniProt:P13639 EEF2
10
EEF2 [secretory granule lumen]
(R-HSA-6801504)
EEF2 [extracellular region]
(R-HSA-6806499)
EEF2 [ficolin-1-rich granule lumen]
(R-HSA-6801513)
EEF2 [cytosol]
(R-HSA-156901)
aminocarboxypropyl EEF2 [cytosol]
(R-HSA-5358478)
Me-diphthine EEF2 [cytosol]
(R-HSA-5367025)
nascent EEF2 [cytosol]
(R-HSA-5358472)
diphthine EEF2 [cytosol]
(R-HSA-5358501)
ADP-ribo-EEF2 [cytosol]
(R-HSA-5334764)
Me3K525-EEF2 [cytosol]
(R-HSA-8932237)
0.527
2
UniProt:P78368 CSNK1G2
2
CSNK1G2 [plasma membrane]
(R-HSA-205718)
CSNK1G2 [cytosol]
(R-HSA-429696)
0.527
3
UniProt:Q96CC6 RHDF1
0.527
2
UniProt:Q15170 TCAL1
0.527
2
UniProt:Q07352 ZFP36L1
3
p-S54,S92,S203-p-ZFP36L1 [cytosol]
(R-HSA-450384)
ZFP36L1 [cytosol]
(R-HSA-450547)
p-S92,S203-ZFP36L1 [cytosol]
(R-HSA-450618)
0.508
2
UniProt:Q92574 TSC1
2
TSC1 [cytosol]
(R-HSA-5672338)
TSC1 [plasma membrane]
(R-HSA-165169)
0.508
2
UniProt:Q969H0 FBXW7
1
FBXW7 [cytosol]
(R-HSA-391304)
0.471
5
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