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MAPK14 [cytosol]
Stable Identifier
R-HSA-428933
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MAP kinase p38 alpha, Mitogen-activated protein kinase 14, MK14_HUMAN, p38 alpha
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Myogenesis (Homo sapiens)
Activation of p38 alpha/beta MAPK (Homo sapiens)
p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
MAPK14 [cytosol] (Homo sapiens)
Interaction of p38 MAPK with JLP (Homo sapiens)
p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
MAPK14 [cytosol] (Homo sapiens)
p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
MAPK14 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
ADP signalling through P2Y purinoceptor 1 (Homo sapiens)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)
MAPK14 [cytosol] (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
Fgr may phosphorylate p38 MAPK (Homo sapiens)
MAPK14 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activation of p38 MAPK (Homo sapiens)
p38 MAPK [cytosol] (Homo sapiens)
MAPK14 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
Binding and activation of MAP Kinase (Homo sapiens)
MAP kinase p38 (Mg2+ cofactor) [cytosol] (Homo sapiens)
MAP kinase p38 [cytosol] (Homo sapiens)
MAPK14 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p38 MAPK activation by VEGFR (Homo sapiens)
MAP kinase p38 (Mg2+ cofactor) [cytosol] (Homo sapiens)
MAP kinase p38 [cytosol] (Homo sapiens)
MAPK14 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16539 MAPK14
Gene Names
MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Chain
initiator methionine:, chain:2-360
Reference Genes
BioGPS Gene:1432 MAPK14
COSMIC (genes):MAPK14 MAPK14
CTD Gene:1432 MAPK14
dbSNP Gene:1432 MAPK14
ENSEMBL:ENSG00000112062 MAPK14
ENSEMBL_homo_sapiens_GENE:ENSG00000112062.12 MAPK14
HGNC:6876 MAPK14
KEGG Gene (Homo sapiens):1432 MAPK14
Monarch:1432 MAPK14
NCBI Gene:1432 MAPK14
OMIM:600289 MAPK14
UCSC:Q16539 MAPK14
Reference Transcript
RefSeq:NM_139013.2 MAPK14
RefSeq:NM_139014.2 MAPK14
RefSeq:NM_001315.2 MAPK14
RefSeq:NM_139012.2 MAPK14
Other Identifiers
11717276_s_at
11742204_a_at
11742487_a_at
11749297_a_at
11753885_a_at
1432
1671_s_at
17007884
1999_s_at
202530_PM_at
202530_at
210449_PM_x_at
210449_x_at
211087_3p_x_at
211087_PM_x_at
211087_x_at
211561_PM_x_at
211561_x_at
232876_PM_at
232876_at
2904878
2904879
2904884
2904885
2904889
2904891
2904892
2904894
2904896
2904907
2904910
2904913
2904914
2904919
2904920
2904921
2904922
2904923
2904924
2904925
2904930
2904932
37733_at
78240_at
8119000
A_14_P111428
A_23_P426292
A_24_P397566
GE492524
GE57735
GO:0000077
GO:0000165
GO:0000166
GO:0000902
GO:0000922
GO:0001502
GO:0001525
GO:0001649
GO:0001890
GO:0002021
GO:0002062
GO:0002376
GO:0002862
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0004708
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0005975
GO:0006006
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006468
GO:0006629
GO:0006886
GO:0006913
GO:0006915
GO:0006935
GO:0006954
GO:0006974
GO:0007155
GO:0007165
GO:0007166
GO:0007178
GO:0007519
GO:0010628
GO:0010831
GO:0012501
GO:0016071
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0018105
GO:0019395
GO:0019899
GO:0019903
GO:0023052
GO:0030154
GO:0030168
GO:0030278
GO:0030316
GO:0031098
GO:0031281
GO:0031410
GO:0031663
GO:0032495
GO:0032496
GO:0032735
GO:0032868
GO:0033554
GO:0034330
GO:0034774
GO:0035331
GO:0035556
GO:0035924
GO:0035994
GO:0036211
GO:0038066
GO:0042060
GO:0042307
GO:0042770
GO:0043226
GO:0045648
GO:0045663
GO:0045944
GO:0046323
GO:0046326
GO:0048010
GO:0048273
GO:0048856
GO:0048863
GO:0051146
GO:0051149
GO:0051403
GO:0051525
GO:0055085
GO:0060045
GO:0060348
GO:0070935
GO:0071222
GO:0071223
GO:0071356
GO:0071479
GO:0071493
GO:0090090
GO:0090336
GO:0090398
GO:0090400
GO:0098586
GO:0098978
GO:0099179
GO:0106310
GO:0140096
GO:1900015
GO:1901741
GO:1904813
GO:2000379
HMNXSV003028633
Hs.258010.0.S1_3p_at
ILMN_1737627
ILMN_2388090
L35253_s_at
L35263_at
PH_hs_0004571
PH_hs_0020050
TC06000523.hg
g405742_3p_s_at
g4503068_3p_at
g7109716_3p_a_at
Participates
as a member of
p38 MAPK alpha/beta/gamma [cytosol] (Homo sapiens)
MAP kinase p38 [cytosol] (Homo sapiens)
as a candidate of
p38 MAPK [cytosol] (Homo sapiens)
as an input of
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)
Fgr may phosphorylate p38 MAPK (Homo sapiens)
Other forms of this molecule
MAPK14 [secretory granule lumen]
MAPK14 [extracellular region]
MAPK14 [ficolin-1-rich granule lumen]
MAPK14 [nucleoplasm]
p-T180,Y182-MAPK14 [cytosol]
p-T180,Y182-MAPK14 [nucleoplasm]
Inferred To
Homologues of MAPK14 [cytosol]
(Caenorhabditis elegans)
Homologues of MAPK14 [cytosol]
(Dictyostelium discoideum)
Homologues of MAPK14 [cytosol]
(Drosophila melanogaster)
MAPK14 [cytosol]
(Bos taurus)
MAPK14 [cytosol]
(Caenorhabditis elegans)
MAPK14 [cytosol]
(Canis familiaris)
MAPK14 [cytosol]
(Danio rerio)
MAPK14 [cytosol]
(Dictyostelium discoideum)
MAPK14 [cytosol]
(Drosophila melanogaster)
MAPK14 [cytosol]
(Gallus gallus)
MAPK14 [cytosol]
(Rattus norvegicus)
MAPK14 [cytosol]
(Saccharomyces cerevisiae)
MAPK14 [cytosol]
(Schizosaccharomyces pombe)
MAPK14 [cytosol]
(Sus scrofa)
MAPK14 [cytosol]
(Xenopus tropicalis)
MAP kinase p38 alpha [cytosol]
(Mus musculus)
gska-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001306.1
,
NP_620582.1
,
NP_620583.1
,
NP_620581.1
ZINC - World Drugs
MK14_HUMAN
Guide to Pharmacology - Targets
1499
OpenTargets
ENSG00000112062
ZINC - FDA approved
MK14_HUMAN
ZINC - Substances
MK14_HUMAN
ZINC - Biogenic
MK14_HUMAN
ZINC target
Q16539
PRO
Q16539
PDB
3UVQ
,
3LHJ
,
2OKR
,
4EH2
,
3L8S
,
3NWW
,
2RG5
,
3K3J
,
3HLL
,
3IW8
,
3LFC
,
4AA0
,
3U8W
,
3QUD
,
6HWV
,
3FI4
,
6SFO
,
3OEF
,
3FLY
,
4EHV
,
3CTQ
,
2BAJ
,
4KIP
,
3NNX
,
3KQ7
,
4E5B
,
3HP2
,
5XYX
,
5OMH
,
3MH1
,
3ZSG
,
3L8X
,
3MW1
,
2FSO
,
4FA2
,
6QDZ
,
4A9Y
,
6HWU
,
5ETF
,
1ZYJ
,
6ZQS
,
2BAK
,
1WBN
,
3FMM
,
1ZZL
,
3E93
,
2LGC
,
3FC1
,
3OC1
,
3IW5
,
1A9U
,
3QUE
,
3GCS
,
6M95
,
4DLI
,
3HV6
,
6ANL
,
4EH7
,
1W83
,
3FKO
,
3ROC
,
3GFE
,
5WJJ
,
3FKL
,
3RIN
,
5MTY
,
1M7Q
,
1OZ1
,
2YIW
,
1WFC
,
2RG6
,
3HEC
,
4AAC
,
2BAL
,
4E6A
,
3LFD
,
3O8T
,
1OUK
,
3GC7
,
1W7H
,
1BMK
,
5N66
,
3HA8
,
3D7Z
,
1YQJ
,
3S3I
,
1WBW
,
5OMG
,
4EH5
,
6SFK
,
3MVL
,
3GI3
,
3FLQ
,
4F9Y
,
3ZSH
,
1OVE
,
3HV3
,
6HWT
,
3ODY
,
5ETI
,
3OCG
,
3HRB
,
3KF7
,
3DS6
,
3LFE
,
5N65
,
2FSL
,
6SFJ
,
4E6C
,
3IW6
,
4AA4
,
3BV2
,
4GEO
,
6QYX
,
3FLS
,
3FMJ
,
4EH8
,
3MGY
,
5ETA
,
2NPQ
,
6TCA
,
3NEW
,
3MH2
,
1OUY
,
3FKN
,
3LFF
,
3OBG
,
3FMN
,
3PG3
,
3UVR
,
4EH3
,
3FLZ
,
1BL7
,
1DI9
,
5ML5
,
3NNU
,
4R3C
,
2Y8O
,
4EH6
,
3O8U
,
5TCO
,
2ZB1
,
3FSF
,
2ZAZ
,
4E5A
,
2ONL
,
1WBT
,
5MTX
,
2YIX
,
4KIQ
,
3HV4
,
1WBO
,
6QE1
,
3ZS5
,
3GCU
,
2YIS
,
6SFI
,
6RFO
,
3HUB
,
3HV7
,
3HP5
,
4E8A
,
3LFA
,
2QD9
,
3D83
,
1W84
,
5MZ3
,
3FL4
,
3C5U
,
1R39
,
4ZTH
,
2FST
,
5ETC
,
3DT1
,
4AA5
,
3FMK
,
5N64
,
3MVM
,
3ZYA
,
4EWQ
,
1KV1
,
2BAQ
,
3FMH
,
3UVP
,
2GFS
,
3FLN
,
5XYY
,
6M9L
,
6ZWP
,
3O8P
,
3MH3
,
3ZSI
,
3K3I
,
3S4Q
,
3HVC
,
4EH4
,
5O8V
,
1R3C
,
3IW7
,
3OBJ
,
3MPA
,
3LFB
,
4F9W
,
3NNV
,
3GCP
,
3ITZ
,
5N63
,
3HL7
,
5N68
,
3IPH
,
1IAN
,
4DLJ
,
1WBV
,
1KV2
,
1WBS
,
4EH9
,
5O8U
,
2FSM
,
1ZZ2
,
3ODZ
,
8A8M
,
3OD6
,
3GCV
,
3FSK
,
3BX5
,
3HUC
,
3FLW
,
3FML
,
3BV3
,
3GCQ
,
1BL6
,
5N67
,
3NNW
,
4KIN
,
4L8M
,
6OHD
,
3E92
,
1W82
,
3HV5
,
3MH0
,
3MPT
,
2ZB0
,
2I0H
,
5TBE
,
3HEG
ZINC - Investigational
MK14_HUMAN
ZINC - Metabolites
MK14_HUMAN
GeneCards
Q16539
HPA
ENSG00000112062-MAPK14
Ensembl
ENST00000229795
,
ENST00000229794
,
ENSG00000112062
,
ENST00000310795
,
ENSP00000229795
,
ENSP00000229794
,
ENSP00000308669
Pharos - Targets
Q16539
ZINC - Predictions - Purchasable
MK14_HUMAN
HMDB Protein
HMDBP01516
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.93
15
UniProt:Q16644 MAPKAPK3
4
MAPKAPK3 [cytosol]
(R-HSA-187764)
MAPKAPK3 [nucleoplasm]
(R-HSA-450218)
p-S,2T-MAPKAPK3 [nucleoplasm]
(R-HSA-450359)
p-S,2T-MAPKAPK3 [cytosol]
(R-HSA-187723)
0.914
15
UniProt:O75676 RPS6KA4
1
RPS6KA4 [cytosol]
(R-HSA-772527)
0.829
9
UniProt:P46734 MAP2K3
3
MAP2K3 [cytosol]
(R-HSA-168051)
p-S218,T222-MAP2K3 [cytosol]
(R-HSA-167955)
p-S218,T222-MAP2K3 [nucleoplasm]
(R-HSA-450229)
0.802
7
UniProt:Q9BUB5 MKNK1
1
p-T250,T255,T385,S437-MKNK1 [cytosol]
(R-HSA-947860)
0.798
7
UniProt:Q9HBH9 MKNK2
0.788
5
UniProt:Q99956 DUSP9
1
DUSP9 [cytosol]
(R-HSA-5675351)
0.779
6
UniProt:P28562 DUSP1
1
DUSP1 [nucleoplasm]
(R-HSA-203796)
0.767
4
UniProt:Q8NEM7 SUPT20H
1
SUPT20H [nucleoplasm]
(R-HSA-3662286)
0.756
5
UniProt:O75147 OBSL1
1
OBSL1 [cytosol]
(R-HSA-8955929)
0.725
4
UniProt:O43257 ZNHI1
0.72
7
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.713
4
UniProt:P27361 MAPK3
6
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [nucleoplasm]
(R-HSA-73724)
MAPK3 [cytosol]
(R-HSA-59284)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
0.691
5
UniProt:Q15256 PTPRR
0.664
4
UniProt:Q9BY84 DUSP16
3
DUSP16 [cytosol]
(R-HSA-5675336)
DUSP16 [nucleoplasm]
(R-HSA-5675337)
Ac-55-DUSP16 [cytosol]
(R-HSA-9636576)
0.659
3
UniProt:Q9H0W5 CCDC8
1
CCDC8 [cytosol]
(R-HSA-8955915)
0.643
3
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.643
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.623
4
UniProt:Q16829 DUSP7
2
DUSP7 [cytosol]
(R-HSA-5675346)
DUSP7 [nucleoplasm]
(R-HSA-203791)
0.59
2
UniProt:P52564 MAP2K6
3
MAP2K6 [cytosol]
(R-HSA-167998)
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
0.564
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q9H869 YYAP1
0.553
2
UniProt:P68104 EEF1A1
7
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
0.547
3
UniProt:Q15759 MAPK11
4
p-T180,Y182-MAPK11 [nucleoplasm]
(R-HSA-198741)
MAPK11 [nucleoplasm]
(R-HSA-203790)
MAPK11 [cytosol]
(R-HSA-170989)
p-T180,Y182-MAPK11 [cytosol]
(R-HSA-171009)
0.547
2
UniProt:Q6PJG2 MDEAS
0.547
2
UniProt:Q14814 MEF2D
1
MEF2D [nucleoplasm]
(R-HSA-445328)
0.547
2
UniProt:O75582 RPS6KA5
3
RPS6KA5 [cytosol]
(R-HSA-772525)
RPS6KA5 [nucleoplasm]
(R-HSA-198657)
p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
(R-HSA-198683)
0.547
3
UniProt:Q96RR4 CAMKK2
4
CAMKK2 [cytosol]
(R-HSA-9619231)
p-CAMKK2 [cytosol]
(R-HSA-9619358)
CAMKK2 [nucleoplasm]
(R-HSA-5336483)
p-CAMKK2 [nucleoplasm]
(R-HSA-9618968)
0.527
2
UniProt:P51784 USP11
1
USP11 [cytosol]
(R-HSA-391303)
0.527
2
UniProt:Q14999 CUL7
1
CUL7 [cytosol]
(R-HSA-535534)
0.527
2
UniProt:P13639 EEF2
10
EEF2 [ficolin-1-rich granule lumen]
(R-HSA-6801513)
EEF2 [extracellular region]
(R-HSA-6806499)
EEF2 [secretory granule lumen]
(R-HSA-6801504)
EEF2 [cytosol]
(R-HSA-156901)
aminocarboxypropyl EEF2 [cytosol]
(R-HSA-5358478)
Me-diphthine EEF2 [cytosol]
(R-HSA-5367025)
nascent EEF2 [cytosol]
(R-HSA-5358472)
diphthine EEF2 [cytosol]
(R-HSA-5358501)
ADP-ribo-EEF2 [cytosol]
(R-HSA-5334764)
Me3K525-EEF2 [cytosol]
(R-HSA-8932237)
0.527
2
UniProt:Q92574 TSC1
2
TSC1 [plasma membrane]
(R-HSA-165169)
TSC1 [cytosol]
(R-HSA-5672338)
0.508
2
UniProt:Q07352 ZFP36L1
3
p-S54,S92,S203-p-ZFP36L1 [cytosol]
(R-HSA-450384)
ZFP36L1 [cytosol]
(R-HSA-450547)
p-S92,S203-ZFP36L1 [cytosol]
(R-HSA-450618)
0.508
2
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