Reactome | MAP2K3 [cytosol]

MAP2K3 [cytosol]

Stable Identifier

R-HSA-168051

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MKK3, Mitogen-activated protein kinase kinase 3

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46734 MAP2K3

Gene Names

MAP2K3, MEK3, MKK3, PRKMK3, SKK2

Chain

chain:1-347

Reference Genes

BioGPS Gene:5606 MAP2K3

COSMIC (genes):MAP2K3 MAP2K3

CTD Gene:5606 MAP2K3

dbSNP Gene:5606 MAP2K3

ENSEMBL:ENSG00000034152 MAP2K3

HGNC:6843 MAP2K3

KEGG:hsa:5606 MAP2K3

Monarch:5606 MAP2K3

NCBI Gene:5606 MAP2K3

OMIM:602315 MAP2K3

UCSC:P46734 MAP2K3

Reference Transcript

Participates

as a member of

MAP2K3,MAP2K6 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S218,T222-MAP2K3 [nucleoplasm]

p-S218,T222-MAP2K3 [cytosol]

Inferred To

MAP2K3 [cytosol] (Bos taurus)

MAP2K3 [cytosol] (Caenorhabditis elegans)

MAP2K3 [cytosol] (Canis familiaris)

MAP2K3 [cytosol] (Dictyostelium discoideum)

MAP2K3 [cytosol] (Gallus gallus)

MAP2K3 [cytosol] (Mus musculus)

MAP2K3 [cytosol] (Rattus norvegicus)

MAP2K3 [cytosol] (Sus scrofa)

lic [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001303261.1, XP_016880348.1, NP_002747.2, XP_011522261.1, XP_005256780.1, NP_659731.1, XP_016880347.1

Guide to Pharmacology - Targets

2064

OpenTargets

ENSG00000034152

ENSEMBL

ENSP00000345083, ENST00000361818, ENST00000316920, ENSP00000355081, ENST00000342679, ENSP00000319139, ENSG00000034152

ZINC - FDA approved

MP2K3_HUMAN

ZINC - Substances

MP2K3_HUMAN

ZINC - Biogenic

MP2K3_HUMAN

ZINC target

P46734

PRO

P46734

GlyGen

P46734

ZINC - Investigational

MP2K3_HUMAN

IntEnz

2.7.12.2

HPA

ENSG00000034152-MAP2K3

GeneCards

MAP2K3

Pharos - Targets

P46734

ZINC - Predictions - Purchasable

MP2K3_HUMAN

HMDB Protein

HMDBP02743

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [cytosol] (R-HSA-428933) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300)	0.802	7
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.757	6
UniProt:P52564 MAP2K6	3	p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) MAP2K6 [cytosol] (R-HSA-167998)	0.615	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.589	5