Reactome | MAP2K3 [cytosol]

MAP2K3 [cytosol]

Stable Identifier

R-HSA-168051

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MKK3, Mitogen-activated protein kinase kinase 3

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        activated TAK1 mediates p38 MAPK activation (Homo sapiens)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
        
        MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
        
        MAP2K3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46734 MAP2K3

Gene Names

MAP2K3, MEK3, MKK3, PRKMK3, SKK2

Chain

chain:1-347

Reference Genes

BioGPS Gene:5606 MAP2K3

COSMIC (genes):MAP2K3 MAP2K3

CTD Gene:5606 MAP2K3

dbSNP Gene:5606 MAP2K3

ENSEMBL:ENSG00000034152.19 MAP2K3

HGNC:6843 MAP2K3

KEGG Gene (Homo sapiens):5606 MAP2K3

Monarch:5606 MAP2K3

NCBI Gene:5606 MAP2K3

OMIM:602315 MAP2K3

UCSC:P46734 MAP2K3

Reference Transcript

Other Identifiers

11742801_a_at

1622_at

16832268

2075_s_at

207667_PM_s_at

207667_s_at

215498_PM_s_at

215498_s_at

215499_PM_at

215499_at

3714730

3714731

3714733

3714735

3714744

3714745

3714748

3714749

3714751

3714752

3714753

3714754

3714755

3714758

3714759

3714764

3714766

3714767

3714768

3714769

3714770

3714772

5606

8005707

A_14_P109219

A_23_P118427

A_24_P296698

D87116_at

GE594548

GE62082

GO:0000165

GO:0000166

GO:0001817

GO:0001934

GO:0002931

GO:0003012

GO:0003013

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0006954

GO:0007165

GO:0007507

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019901

GO:0023052

GO:0035331

GO:0035924

GO:0036211

GO:0038066

GO:0043226

GO:0043410

GO:0043536

GO:0045860

GO:0045893

GO:0048856

GO:0048870

GO:0051770

GO:0060048

GO:0071222

GO:0072709

GO:0090398

GO:0106310

GO:0140096

HMNXSV003017442

HMNXSV003039726

Hs.180533.2.S1_3p_a_at

Hs.180533.2.S1_3p_x_at

ILMN_1668909

ILMN_1680777

ILMN_1790534

PH_hs_0010680

TC17000297.hg

TC17002123.hg

g4506098_3p_a_at

Participates

as a member of

MAP2K3,MAP2K6 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S218,T222-MAP2K3 [cytosol]

p-S218,T222-MAP2K3 [nucleoplasm]

Inferred To

Homologues of MAP2K3 [cytosol] (Caenorhabditis elegans)

Homologues of MAP2K3 [cytosol] (Saccharomyces cerevisiae)

Homologues of MAP2K3 [cytosol] (Schizosaccharomyces pombe)

MAP2K3 [cytosol] (Bos taurus)

MAP2K3 [cytosol] (Caenorhabditis elegans)

MAP2K3 [cytosol] (Canis familiaris)

MAP2K3 [cytosol] (Dictyostelium discoideum)

MAP2K3 [cytosol] (Gallus gallus)

MAP2K3 [cytosol] (Mus musculus)

MAP2K3 [cytosol] (Rattus norvegicus)

MAP2K3 [cytosol] (Saccharomyces cerevisiae)

MAP2K3 [cytosol] (Schizosaccharomyces pombe)

MAP2K3 [cytosol] (Sus scrofa)

sek-4 [cytosol] (Caenorhabditis elegans)

sek-5 [cytosol] (Caenorhabditis elegans)

lic [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_659731.1, NP_002747.2, XP_011522261.1, XP_016880347.1, XP_005256780.1, XP_016880348.1, NP_001303261.1

ZINC - World Drugs

MP2K3_HUMAN

Guide to Pharmacology - Targets

2064

OpenTargets

ENSG00000034152

ZINC - FDA approved

MP2K3_HUMAN

ZINC - Substances

MP2K3_HUMAN

ZINC - Biogenic

MP2K3_HUMAN

ZINC target

P46734

PRO

P46734

ZINC - Investigational

MP2K3_HUMAN

IntEnz

2.7.12.2

HPA

ENSG00000034152-MAP2K3

GeneCards

P46734

Ensembl

ENSP00000345083, ENSP00000355081, ENST00000361818, ENST00000316920, ENSP00000478619, ENST00000613338, ENSP00000319139, ENSG00000034152, ENST00000342679

Pharos - Targets

P46734

ZINC - Predictions - Purchasable

MP2K3_HUMAN

HMDB Protein

HMDBP02743

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.757	6
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.744	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.589	5
UniProt:P52564 MAP2K6	3	p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) MAP2K6 [cytosol] (R-HSA-167998)	0.483	2

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