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MAP2K3 [cytosol]
Stable Identifier
R-HSA-168051
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MKK3, Mitogen-activated protein kinase kinase 3
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
MAP2K3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46734 MAP2K3
Gene Names
MAP2K3, MEK3, MKK3, PRKMK3, SKK2
Chain
chain:1-347
Reference Genes
BioGPS Gene:5606 MAP2K3
COSMIC (genes):MAP2K3 MAP2K3
CTD Gene:5606 MAP2K3
dbSNP Gene:5606 MAP2K3
ENSEMBL:ENSG00000034152 MAP2K3
HGNC:6843 MAP2K3
KEGG:hsa:5606 MAP2K3
Monarch:5606 MAP2K3
NCBI Gene:5606 MAP2K3
OMIM:602315 MAP2K3
UCSC:P46734 MAP2K3
Reference Transcript
RefSeq:XM_017024859.1 MAP2K3
RefSeq:NM_002756.4 MAP2K3
RefSeq:XM_017024858.1 MAP2K3
RefSeq:XM_005256723.2 MAP2K3
RefSeq:NM_001316332.1 MAP2K3
RefSeq:NM_145109.2 MAP2K3
RefSeq:XM_011523959.1 MAP2K3
Participates
as a member of
MAP2K3,MAP2K6 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S218,T222-MAP2K3 [nucleoplasm]
p-S218,T222-MAP2K3 [cytosol]
Inferred To
MAP2K3 [cytosol]
(Bos taurus)
MAP2K3 [cytosol]
(Caenorhabditis elegans)
MAP2K3 [cytosol]
(Canis familiaris)
MAP2K3 [cytosol]
(Dictyostelium discoideum)
MAP2K3 [cytosol]
(Gallus gallus)
MAP2K3 [cytosol]
(Mus musculus)
MAP2K3 [cytosol]
(Rattus norvegicus)
MAP2K3 [cytosol]
(Sus scrofa)
lic [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001303261.1
,
XP_016880348.1
,
NP_002747.2
,
XP_011522261.1
,
XP_005256780.1
,
NP_659731.1
,
XP_016880347.1
Guide to Pharmacology - Targets
2064
OpenTargets
ENSG00000034152
ENSEMBL
ENSP00000345083
,
ENST00000361818
,
ENST00000316920
,
ENSP00000355081
,
ENST00000342679
,
ENSP00000319139
,
ENSG00000034152
ZINC - FDA approved
MP2K3_HUMAN
ZINC - Substances
MP2K3_HUMAN
ZINC - Biogenic
MP2K3_HUMAN
ZINC target
P46734
PRO
P46734
GlyGen
P46734
ZINC - Investigational
MP2K3_HUMAN
IntEnz
2.7.12.2
HPA
ENSG00000034152-MAP2K3
GeneCards
MAP2K3
Pharos - Targets
P46734
ZINC - Predictions - Purchasable
MP2K3_HUMAN
HMDB Protein
HMDBP02743
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16539 MAPK14
7
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
MAPK14 [cytosol]
(R-HSA-428933)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
0.802
7
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.757
6
UniProt:P52564 MAP2K6
3
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
MAP2K6 [cytosol]
(R-HSA-167998)
0.615
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.589
5
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