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MAPK14 [nucleoplasm]
Stable Identifier
R-MMU-446223
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
P47811
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
Oxidative Stress Induced Senescence (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Mus musculus)
p38 MAPK:MAPKAPK5 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)
p38 MAPK:MAPKAPK2,3 [nucleoplasm] (Mus musculus)
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
MAPK14 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P47811 Mapk14
Gene Names
Mapk14, Crk1, Csbp1, Csbp2
Chain
initiator methionine:, chain:2-360
Reference Genes
BioGPS Gene:26416 Mapk14
KEGG:mmu:26416 Mapk14
Monarch:26416 Mapk14
NCBI Gene:26416 Mapk14
UCSC:P47811 Mapk14
Reference Transcript
RefSeq:NM_001168513.1 Mapk14
RefSeq:NM_011951.3 Mapk14
RefSeq:NM_001168508.1 Mapk14
RefSeq:NM_001168514.1 Mapk14
Other Identifiers
10443391
1416703_at
1416704_at
1426104_at
1451927_a_at
17335364
26416
4349741
4360135
4367227
4392113
4419112
4477435
4497133
4607276
4634824
4635784
4700291
4800721
5014179
5026222
5057666
5134852
5175049
5282237
5296355
5365849
5376071
5555444
5587922
99978_s_at
A_51_P325343
A_55_P2046338
A_55_P2179348
GE37793
GO:0000077
GO:0000165
GO:0000902
GO:0000922
GO:0001502
GO:0001525
GO:0001649
GO:0001890
GO:0002021
GO:0002062
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006006
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006468
GO:0006629
GO:0006915
GO:0006974
GO:0007178
GO:0007519
GO:0010628
GO:0010831
GO:0012501
GO:0016301
GO:0016607
GO:0016740
GO:0018105
GO:0019395
GO:0019899
GO:0019903
GO:0030154
GO:0030278
GO:0030316
GO:0031098
GO:0031663
GO:0032495
GO:0032496
GO:0032735
GO:0032868
GO:0035331
GO:0035556
GO:0035924
GO:0035994
GO:0038066
GO:0042307
GO:0042770
GO:0043226
GO:0045648
GO:0045663
GO:0045944
GO:0046323
GO:0046326
GO:0048010
GO:0048273
GO:0048856
GO:0048863
GO:0051146
GO:0051403
GO:0051525
GO:0055085
GO:0060045
GO:0060348
GO:0071222
GO:0071223
GO:0071356
GO:0071479
GO:0071493
GO:0090090
GO:0090336
GO:0090400
GO:0098586
GO:0098978
GO:0099179
GO:0106310
GO:0140096
GO:1900015
GO:1901741
GO:2000379
ILMN_2491705
ILMN_2721809
Msa.8386.0_s_at
mMC002605
u10871_s_at
Participates
as a member of
MAP kinase p38 alpha/beta [nucleoplasm] (Mus musculus)
Other forms of this molecule
p-T180,Y182-Mapk14 [nucleoplasm]
phospho-MAP kinase p38 alpha [cytosol]
MAP kinase p38 alpha [cytosol]
MAPK14 [secretory granule lumen]
MAPK14 [extracellular region]
MAPK14 [ficolin-1-rich granule lumen]
Inferred From
MAPK14 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001161980.1
,
NP_036081.1
,
NP_001161986.1
,
NP_001161985.1
ZINC - Investigational
MK14_MOUSE
ENSEMBL
ENSMUSP00000004990
,
ENSMUST00000062694
,
ENSMUSP00000110406
,
ENSMUSP00000061958
,
ENSMUST00000114758
,
ENSMUSP00000110402
,
ENSMUST00000114752
,
ENSMUST00000004990
,
ENSMUST00000114754
,
ENSMUSP00000110400
IntEnz
2.7.11.24
ZINC - Substances
MK14_MOUSE
ZINC target
P47811
PRO
P47811
MGI
1346865
ZINC - Predictions - Purchasable
MK14_MOUSE
PDB
3P79
,
5O90
,
5R9R
,
5R93
,
6SOD
,
2GTM
,
5R9B
,
5R8Z
,
5R9Y
,
5R9Q
,
6SP9
,
3TG1
,
5RA9
,
5RA0
,
6Y80
,
4TYH
,
4LOQ
,
5NZZ
,
5R97
,
7BE5
,
3P4K
,
5R95
,
5R9F
,
5R8X
,
5RA7
,
5R9M
,
6SO4
,
6Y4X
,
3P7C
,
3P7A
,
6Y8H
,
1LEW
,
2EWA
,
2PUU
,
5R9K
,
5R9S
,
5R9Z
,
4LOP
,
2GTN
,
5R9C
,
5RA8
,
5R91
,
5RA1
,
4KA3
,
2GHL
,
3P78
,
5RA4
,
5R8V
,
6SO2
,
6SOV
,
5R9G
,
5R98
,
5R9V
,
5R9N
,
5R96
,
5R9T
,
3P7B
,
6Y85
,
8ACM
,
6Y4U
,
6Y7X
,
3P5K
,
2OZA
,
4LOO
,
6YK7
,
5RA2
,
5R9P
,
5R9H
,
5R90
,
5R9A
,
7Z9T
,
2GHM
,
6Y81
,
6ZWR
,
5R92
,
5RA5
,
7BE4
,
7BDQ
,
8EFJ
,
5R94
,
8ACO
,
5R9O
,
5R8W
,
6SOT
,
5R9D
,
6Y6V
,
5R8U
,
1YWR
,
1LEZ
,
6Y4V
,
6Y7Y
,
6SO1
,
5RA3
,
5R9I
,
5R8Y
,
5R9X
,
6YCU
,
7BDO
,
6SOI
,
6Y82
,
5R9J
,
7PVU
,
7Z6I
,
6YCW
,
5R9U
,
6SPL
,
3PY3
,
5R99
,
5R9W
,
6SOU
,
5R9E
,
5RA6
,
5R9L
,
1YW2
,
5UOJ
,
6Y4W
,
5LAR
,
6Y7W
,
6YJC
,
6Y4T
,
6Y7Z
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35236 PTPN7
2
PTPN7 [cytosol]
(R-HSA-9635737)
PTPN7 [nucleoplasm]
(R-HSA-9008913)
0.589
2
UniProt:P49137-1 MAPKAPK2
0.558
2
IntAct:EBI-15896509 PEPMEK3B
0.558
2
UniProt:P49138
5
MAPKAPK2 [cytosol]
(R-MMU-187743)
phospho-p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-MMU-199936)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-MMU-187760)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-MMU-450268)
MAPKAPK2 [nucleoplasm]
(R-MMU-450235)
0.527
2
UniProt:Q99956 DUSP9
1
DUSP9 [cytosol]
(R-HSA-5675351)
0.527
2
UniProt:P55012
1
SLC12A2 [plasma membrane]
(R-MMU-426146)
0.499
2
UniProt:Q9Z1W9 STK39
0.499
2
UniProt:Q9WVS6
4
polyUb-PARK2 [cytosol]
(R-MMU-5689094)
phospho-p-S9-PRKN [cytosol]
(R-MMU-9793481)
phospho-p-S65-PRKN [cytosol]
(R-MMU-9834954)
PRKN [cytosol]
(R-MMU-201579)
0.463
3
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