Reactome | p-S207,T211-MAP2K6 [cytosol]

p-S207,T211-MAP2K6 [cytosol]

Stable Identifier

R-HSA-206255

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S207,T211-MKK6

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P52564 MAP2K6

Gene Names

MAP2K6, MEK6, MKK6, PRKMK6, SKK3

Chain

chain:1-334

Reference Genes

BioGPS Gene:5608 MAP2K6

COSMIC (genes):MAP2K6 MAP2K6

CTD Gene:5608 MAP2K6

dbSNP Gene:5608 MAP2K6

ENSEMBL:ENSG00000108984.15 MAP2K6

HGNC:6846 MAP2K6

KEGG Gene (Homo sapiens):5608 MAP2K6

Monarch:5608 MAP2K6

NCBI Gene:5608 MAP2K6

OMIM:601254 MAP2K6

UCSC:P52564 MAP2K6

Reference Transcript

RefSeq:NM_002758.3 MAP2K6

Other Identifiers

0003140537

0005270575

11724606_a_at

11758909_at

1543_at

16837348

2014_s_at

205698_PM_s_at

205698_s_at

205699_PM_at

205699_at

229569_PM_at

229569_at

3725938

3733071

3733072

3733073

3733082

3733083

3733084

3733089

3733091

3733092

3733093

3733095

3733097

3733099

3733101

3733104

3733107

3733113

3733118

3733119

3733120

3733121

3733122

3733123

3733124

3733125

3733126

3733127

43958_at

5608

76095_at

7896639

8009476

83039_at

A_14_P106339

A_14_P130621

A_14_P201634

A_19_P00316010

A_19_P00812873

A_23_P207445

A_24_P416489

A_32_P44210

GE59129

GE608685

GE613227

GO:0000165

GO:0000166

GO:0001649

GO:0001934

GO:0002376

GO:0002931

GO:0003012

GO:0003013

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006468

GO:0006915

GO:0006975

GO:0007165

GO:0009410

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019211

GO:0019901

GO:0022414

GO:0022602

GO:0023052

GO:0030154

GO:0032308

GO:0036211

GO:0038066

GO:0043065

GO:0043226

GO:0043406

GO:0043410

GO:0043539

GO:0048856

GO:0051403

GO:0051726

GO:0051770

GO:0060048

GO:0060348

GO:0070423

GO:0072709

GO:0090398

GO:0098772

GO:0106310

GO:0120163

GO:0140096

GO:1901796

HMNXSV003039586

Hs.26017.0.A1_3p_at

ILMN_1660964

ILMN_1697729

PH_hs_0023282

TC17000807.hg

U39657_at

g10835026_3p_a_at

g1203817_3p_at

p7482

Participates

as an output of

TAK1 phosphorylates MKK6 (Homo sapiens)

as a member of

p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S207,T211-MAP2K6 [nucleoplasm]

MAP2K6 [cytosol]

Inferred To

phospho-p-S207,T211-MAP2K6 [cytosol] (Bos taurus)

phospho-p-S207,T211-MAP2K6 [cytosol] (Caenorhabditis elegans)

phospho-p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)

phospho-p-S207,T211-MAP2K6 [cytosol] (Danio rerio)

phospho-p-S207,T211-MAP2K6 [cytosol] (Dictyostelium discoideum)

phospho-p-S207,T211-MAP2K6 [cytosol] (Gallus gallus)

phospho-p-S207,T211-MAP2K6 [cytosol] (Rattus norvegicus)

phospho-p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S207,T211-MAP2K6 [cytosol] (Schizosaccharomyces pombe)

phospho-p-S207,T211-MAP2K6 [cytosol] (Sus scrofa)

phospho-p-S207,T211-MAP2K6 [cytosol] (Xenopus tropicalis)

Phospho MKK6_MOUSE [cytosol] (Mus musculus)

phospho-lic [cytosol] (Drosophila melanogaster)

Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-S207,T211-MAP2K6 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-serine at 207

Coordinate

207

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 211

Coordinate

211

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_002749.2

ZINC - World Drugs

MP2K6_HUMAN

Guide to Pharmacology - Targets

2067

OpenTargets

ENSG00000108984

ZINC - FDA approved

MP2K6_HUMAN

ZINC - Substances

MP2K6_HUMAN

ZINC target

P52564

ZINC - Biogenic

MP2K6_HUMAN

PRO

P52564

PDB

5ETF, 2Y8O, 3FME, 3ENM, 3VN9

ZINC - Investigational

MP2K6_HUMAN

HPA

ENSG00000108984-MAP2K6

GeneCards

P52564

Ensembl

ENST00000590474, ENSP00000468348, ENST00000589647, ENSG00000108984, ENSP00000477701, ENST00000613873, ENSP00000467213

Pharos - Targets

P52564

ZINC - Predictions - Purchasable

MP2K6_HUMAN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	12	p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) ub-NFE2L2 [cytosol] (R-HSA-9758077) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.625	5
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.564	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.519	2
UniProt:Q9Y6R4 M3K4			0.519	2
UniProt:P46734 MAP2K3	3	MAP2K3 [cytosol] (R-HSA-168051) p-S189,T193-MAP2K3 [cytosol] (R-HSA-167955) p-S189,T193-MAP2K3 [nucleoplasm] (R-HSA-450229)	0.483	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.463	4