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p-S207,T211-MAP2K6 [cytosol]
Stable Identifier
R-HSA-206255
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S207,T211-MKK6
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Myogenesis (Homo sapiens)
Activation of p38 alpha/beta MAPK (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1 phosphorylates MKK6 (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activation of p38 MAPK (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
TAK1 phosphorylates MKK6 (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52564 MAP2K6
Gene Names
MAP2K6, MEK6, MKK6, PRKMK6, SKK3
Chain
chain:1-334
Reference Genes
BioGPS Gene:5608 MAP2K6
COSMIC (genes):MAP2K6 MAP2K6
CTD Gene:5608 MAP2K6
dbSNP Gene:5608 MAP2K6
ENSEMBL:ENSG00000108984 MAP2K6
HGNC:6846 MAP2K6
KEGG Gene (Homo sapiens):5608 MAP2K6
Monarch:5608 MAP2K6
NCBI Gene:5608 MAP2K6
OMIM:601254 MAP2K6
UCSC:P52564 MAP2K6
Reference Transcript
RefSeq:NM_002758.3 MAP2K6
Other Identifiers
0003140537
0005270575
11724606_a_at
11758909_at
1543_at
16837348
2014_s_at
205698_s_at
205699_at
229569_at
3725938
3733071
3733072
3733073
3733082
3733083
3733084
3733089
3733091
3733092
3733093
3733095
3733097
3733099
3733101
3733104
3733107
3733113
3733118
3733119
3733120
3733121
3733122
3733123
3733124
3733125
3733126
3733127
43958_at
5608
76095_at
7896639
8009476
83039_at
A_14_P106339
A_14_P130621
A_14_P201634
A_19_P00316010
A_19_P00812873
A_23_P207445
A_24_P416489
A_32_P44210
GE59129
GE608685
GE613227
GO:0000003
GO:0000165
GO:0000166
GO:0000187
GO:0001934
GO:0002931
GO:0003013
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0006950
GO:0006975
GO:0007049
GO:0007050
GO:0007165
GO:0007267
GO:0008150
GO:0008219
GO:0009058
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0022602
GO:0032308
GO:0042493
GO:0042592
GO:0043065
GO:0043167
GO:0043226
GO:0051770
GO:0060048
GO:0070423
GO:0072709
GO:0120163
Hs.26017.0.A1_3p_at
ILMN_1660964
ILMN_1697729
PH_hs_0023282
TC17000807.hg
U39657_at
g10835026_3p_a_at
g1203817_3p_at
Participant Of
output
TAK1 phosphorylates MKK6
hasMember
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol]
Other forms of this molecule
p-S207,T211-MAP2K6 [nucleoplasm]
MAP2K6 [cytosol]
Inferred To
phospho-byr1 [cytosol] (Schizosaccharomyces pombe)
phospho-skh1 [cytosol] (Schizosaccharomyces pombe)
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
phospho-lic [cytosol] (Drosophila melanogaster)
phospho-MKK2 [cytosol] (Saccharomyces cerevisiae)
phospho-sek-1 [cytosol] (Caenorhabditis elegans)
phospho-wis1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-S207,T211-MAP2K6 [cytosol] (Xenopus tropicalis)
phospho-MAP2K6 [cytosol] (Canis familiaris)
phospho-MAP2K6 [cytosol] (Gallus gallus)
phospho-MAP2K6 [cytosol] (Sus scrofa)
phospho-MKK1 [cytosol] (Saccharomyces cerevisiae)
phospho-Map2k6 [cytosol] (Rattus norvegicus)
phospho-PBS2 [cytosol] (Saccharomyces cerevisiae)
Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
Homologues of p-S207,T211-MAP2K6 [cytosol] (Schizosaccharomyces pombe)
phospho-map2k6 [cytosol] (Danio rerio)
Modified Residues
Name
O-phospho-L-serine at 207
Coordinate
207
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 211
Coordinate
211
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_002749.2
ZINC - World Drugs
MP2K6_HUMAN
OpenTargets
ENSG00000108984
ZINC - FDA approved
MP2K6_HUMAN
ZINC - Substances
MP2K6_HUMAN
ZINC target
P52564
ZINC - Biogenic
MP2K6_HUMAN
PRO
P52564
PDB
2Y8O
,
3ENM
,
5ETF
,
3FME
,
3VN9
ZINC - Investigational
MP2K6_HUMAN
HPA
ENSG00000108984-MAP2K6
GeneCards
P52564
Ensembl
ENSP00000467213
,
ENST00000613873
,
ENST00000590474
,
ENSP00000477701
,
ENSG00000108984
,
ENST00000589647
,
ENSP00000468348
ZINC - Predictions - Purchasable
MP2K6_HUMAN
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16236 NF2L2
0.625
5
UniProt:P24522 GADD45A
1
GADD45A [nucleoplasm]
(R-HSA-3215139)
0.573
2
UniProt:Q9Y6R4 M3K4
0.573
2
UniProt:O76024 WFS1
3
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.463
4
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