Reactome | p-S207,T211-MAP2K6 [cytosol]

p-S207,T211-MAP2K6 [cytosol]

Stable Identifier

R-HSA-206255

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S207,T211-MKK6

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P52564 MAP2K6

Gene Names

MAP2K6, MEK6, MKK6, PRKMK6, SKK3

Chain

chain:1-334

Reference Genes

BioGPS Gene:5608 MAP2K6

COSMIC (genes):MAP2K6 MAP2K6

CTD Gene:5608 MAP2K6

dbSNP Gene:5608 MAP2K6

ENSEMBL:ENSG00000108984 MAP2K6

HGNC:6846 MAP2K6

KEGG:hsa:5608 MAP2K6

Monarch:5608 MAP2K6

NCBI Gene:5608 MAP2K6

OMIM:601254 MAP2K6

UCSC:P52564 MAP2K6

Reference Transcript

Participates

as an output of

as a member of

p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S207,T211-MAP2K6 [nucleoplasm]

MAP2K6 [cytosol]

Inferred To

Phospho MKK6_MOUSE [cytosol] (Mus musculus)

phospho-lic [cytosol] (Drosophila melanogaster)

phospho-nek4 [cytosol] (Dictyostelium discoideum)

phospho-sek-1 [cytosol] (Caenorhabditis elegans)

phospho-jkk-1 [cytosol] (Caenorhabditis elegans)

phospho-sek-4 [cytosol] (Caenorhabditis elegans)

phospho-sek-5 [cytosol] (Caenorhabditis elegans)

phospho-mek-5 [cytosol] (Caenorhabditis elegans)

phospho-p-S207,T211-MAP2K6 [cytosol] (Canis familiaris)

phospho-p-S207,T211-MAP2K6 [cytosol] (Gallus gallus)

phospho-MAP2K6 [cytosol] (Bos taurus)

phospho-MAP2K6 [cytosol] (Sus scrofa)

phospho-sek-3 [cytosol] (Caenorhabditis elegans)

phospho-strd-1 [cytosol] (Caenorhabditis elegans)

phospho-Map2k6 [cytosol] (Rattus norvegicus)

Homologues of p-S207,T211-MAP2K6 [cytosol] (Caenorhabditis elegans)

phospho-map2k6 [cytosol] (Danio rerio)

phospho-map2k6 [cytosol] (Xenopus tropicalis)

phospho-mek-1 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 207

Coordinate

207

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 211

Coordinate

211

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001317379.1, XP_005257573.1, XP_054172663.1, XP_054172664.1, XP_047292367.1, XP_054172662.1, XP_006722038.1, XP_054172661.1, XP_011523329.1, NP_002749.2

ZINC - World Drugs

MP2K6_HUMAN

Guide to Pharmacology - Targets

2067

OpenTargets

ENSG00000108984

ENSEMBL

ENST00000590474, ENSP00000467213, ENST00000589647, ENSP00000468348, ENSG00000108984

ZINC - FDA approved

MP2K6_HUMAN

ZINC - Substances

MP2K6_HUMAN

ZINC - Biogenic

MP2K6_HUMAN

ZINC target

P52564

PRO

P52564

GlyGen

P52564

PDB

5ETF, 8A8M, 8PM3, 3ENM, 2Y8O, 3VN9, 3FME, 8P7J

ZINC - Investigational

MP2K6_HUMAN

HPA

ENSG00000108984-MAP2K6

GeneCards

MAP2K6

Pharos - Targets

P52564

ZINC - Predictions - Purchasable

MP2K6_HUMAN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.625	5
UniProt:P46734 MAP2K3	3	p-S218,T222-MAP2K3 [nucleoplasm] (R-HSA-450229) p-S218,T222-MAP2K3 [cytosol] (R-HSA-167955) MAP2K3 [cytosol] (R-HSA-168051)	0.615	3
UniProt:Q16539 MAPK14	7	p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [cytosol] (R-HSA-428933) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300)	0.564	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9Y6R4 M3K4			0.519	2
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.519	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.463	4

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