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p-CAMKK2 [cytosol]
Stable Identifier
R-HSA-9619358
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of AMPK downstream of NMDARs (Homo sapiens)
CAMKK2 phosphorylates AMPK (Homo sapiens)
p-CAMKK2:CALM1:4xCa2+ [cytosol] (Homo sapiens)
p-CAMKK2 [cytosol] (Homo sapiens)
Activation of RAC1 downstream of NMDARs (Homo sapiens)
CaMKK autophosphorylates in the cytosol (Homo sapiens)
p-CaMKK:CALM1:4xCa2+ [cytosol] (Homo sapiens)
p-CaMKK [cytosol] (Homo sapiens)
p-CAMKK2 [cytosol] (Homo sapiens)
CaMKKs phosphorylate CAMK1 (Homo sapiens)
p-CaMKK:CALM1:4xCa2+ [cytosol] (Homo sapiens)
p-CaMKK [cytosol] (Homo sapiens)
p-CAMKK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96RR4 CAMKK2
Gene Names
CAMKK2, CAMKKB, KIAA0787
Chain
initiator methionine:1, chain:2-588
Reference Genes
BioGPS Gene:10645 CAMKK2
COSMIC (genes):CAMKK2 CAMKK2
CTD Gene:10645 CAMKK2
dbSNP Gene:10645 CAMKK2
ENSEMBL:ENSG00000110931 CAMKK2
ENSEMBL:ENSG00000110931.19 CAMKK2
HGNC:1470 CAMKK2
KEGG Gene (Homo sapiens):10645 CAMKK2
Monarch:10645 CAMKK2
NCBI Gene:10645 CAMKK2
OMIM:615002 CAMKK2
UCSC:Q96RR4 CAMKK2
Reference Transcript
RefSeq:NM_001270486.1 CAMKK2
RefSeq:NM_153499.2 CAMKK2
RefSeq:NM_172216.1 CAMKK2
RefSeq:XM_005253823.1 CAMKK2
RefSeq:XM_011537763.1 CAMKK2
RefSeq:NM_172214.2 CAMKK2
RefSeq:XM_017018704.1 CAMKK2
RefSeq:XM_017018701.1 CAMKK2
RefSeq:NM_001270485.1 CAMKK2
RefSeq:NM_006549.3 CAMKK2
RefSeq:NM_153500.1 CAMKK2
RefSeq:XM_005253824.3 CAMKK2
RefSeq:NM_172215.2 CAMKK2
RefSeq:NM_172226.2 CAMKK2
RefSeq:XM_017018698.1 CAMKK2
RefSeq:XM_017018702.1 CAMKK2
Other Identifiers
10645
11729541_a_at
11729542_a_at
11731375_a_at
11731645_a_at
16651731
16651733
16651735
16651737
16651739
16651741
16651743
16651899
16771430
18670972
18670973
18670974
18670975
18670976
18670977
18670978
18670979
18670980
18670981
18670982
18670983
18670984
18670987
18670988
18670990
18670991
18670992
18670993
210787_PM_s_at
210787_s_at
212252_PM_at
212252_at
213812_PM_s_at
213812_s_at
3474886
3474887
3474888
3474889
3474890
3474891
3474895
3474896
3474897
3474898
3474900
3474902
3474903
3474904
3474905
3474909
3474910
3474913
3474914
3474917
3474918
3474919
3474920
3474921
3474933
3474934
38716_at
64341_f_at
7967127
A_23_P358957
A_23_P408830
GE53489
GO:0000165
GO:0000166
GO:0001934
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0004713
GO:0005509
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006914
GO:0007005
GO:0016301
GO:0016310
GO:0016740
GO:0019722
GO:0023052
GO:0032147
GO:0034614
GO:0036211
GO:0042995
GO:0043005
GO:0043226
GO:0045859
GO:0045893
GO:0046777
GO:0061762
GO:0106310
GO:0140096
GO:1903599
HMNXSV003018639
HMNXSV003041113
Hs.108708.2.S1_3p_a_at
Hs.108708.3.S1_3p_at
ILMN_1743021
ILMN_2367638
PH_hs_0023571
TC12002061.hg
g4877950_3p_a_at
g5729894_3p_at
Participates
as a member of
p-CaMKK [cytosol] (Homo sapiens)
as a component of
p-CAMKK2:CALM1:4xCa2+ [cytosol] (Homo sapiens)
Other forms of this molecule
CAMKK2 [cytosol]
CAMKK2 [nucleoplasm]
p-CAMKK2 [nucleoplasm]
Inferred To
phospho-p-CAMKK2 [cytosol]
(Bos taurus)
phospho-p-CAMKK2 [cytosol]
(Caenorhabditis elegans)
phospho-p-CAMKK2 [cytosol]
(Canis familiaris)
phospho-p-CAMKK2 [cytosol]
(Danio rerio)
phospho-p-CAMKK2 [cytosol]
(Mus musculus)
phospho-p-CAMKK2 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
XP_016874191.1
,
NP_757380.1
,
NP_001257415.1
,
XP_016874190.1
,
NP_705719.2
,
NP_001257414.1
,
NP_757363.1
,
XP_005253881.1
,
XP_016874187.1
,
XP_005253880.1
,
XP_016874193.1
,
NP_705720.1
,
XP_011536065.1
,
NP_757365.1
,
NP_006540.3
,
NP_757364.1
ZINC - World Drugs
KKCC2_HUMAN
Guide to Pharmacology - Targets
1957
OpenTargets
ENSG00000110931
ZINC - FDA approved
KKCC2_HUMAN
ZINC - Substances
KKCC2_HUMAN
ZINC - Biogenic
KKCC2_HUMAN
ZINC target
Q96RR4
PRO
Q96RR4
PDB
6BQQ
,
5YVA
,
6Y4K
,
6Y3O
,
6Y8A
,
6Y6B
,
6BQP
,
6BRC
,
5VT1
,
6BQL
,
6BKU
,
6FEL
,
2ZV2
,
5YV9
,
6BLE
,
5UY6
,
6CMJ
,
5UYJ
,
5YVB
,
5YV8
,
5YVC
,
6EWW
,
6EF5
ZINC - Investigational
KKCC2_HUMAN
GeneCards
Q96RR4
HPA
ENSG00000110931-CAMKK2
Ensembl
ENSP00000376265
,
ENST00000347034
,
ENST00000652382
,
ENST00000404169
,
ENSP00000321230
,
ENSP00000384600
,
ENST00000412367
,
ENST00000538733
,
ENSP00000388368
,
ENSP00000384591
,
ENST00000402834
,
ENSP00000376266
,
ENSP00000445944
,
ENSP00000312741
,
ENST00000446440
,
ENST00000337174
,
ENSG00000110931
,
ENSP00000498824
,
ENST00000324774
,
ENST00000392473
,
ENSP00000388273
,
ENST00000392474
,
ENSP00000336634
Pharos - Targets
Q96RR4
ZINC - Predictions - Purchasable
KKCC2_HUMAN
HMDB Protein
HMDBP01346
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75147 OBSL1
1
OBSL1 [cytosol]
(R-HSA-8955929)
0.527
2
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