Reactome | p-CAMKK2 [cytosol]

p-CAMKK2 [cytosol]

Stable Identifier

R-HSA-9619358

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96RR4 CAMKK2

Gene Names

CAMKK2, CAMKKB, KIAA0787

Chain

initiator methionine:, chain:2-588

Reference Genes

BioGPS Gene:10645 CAMKK2

COSMIC (genes):CAMKK2 CAMKK2

CTD Gene:10645 CAMKK2

dbSNP Gene:10645 CAMKK2

ENSEMBL:ENSG00000110931 CAMKK2

HGNC:1470 CAMKK2

KEGG:hsa:10645 CAMKK2

Monarch:10645 CAMKK2

NCBI Gene:10645 CAMKK2

OMIM:615002 CAMKK2

UCSC:Q96RR4 CAMKK2

Reference Transcript

Other Identifiers

10645

11729541_a_at

11729542_a_at

11731375_a_at

11731645_a_at

16651731

16651733

16651735

16651737

16651739

16651741

16651743

16651805

16651807

16651809

16651811

16651813

16651841

16651847

16651873

16651899

16771430

18670972

18670973

18670974

18670975

18670976

18670977

18670978

18670979

18670980

18670981

18670982

18670983

18670984

18670985

18670986

18670987

18670988

18670989

18670990

18670991

18670992

18670993

210787_PM_s_at

210787_s_at

212252_PM_at

212252_at

213812_PM_s_at

213812_s_at

3474886

3474887

3474888

3474889

3474890

3474891

3474895

3474896

3474897

3474898

3474900

3474902

3474903

3474904

3474905

3474909

3474910

3474911

3474912

3474913

3474914

3474917

3474918

3474919

3474920

3474921

3474933

3474934

38716_at

64341_f_at

7967127

A_23_P358957

A_23_P408830

GE53489

GO:0000165

GO:0001934

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0004713

GO:0005509

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0016740

GO:0019722

GO:0034614

GO:0042995

GO:0043005

GO:0043226

GO:0045859

GO:0045893

GO:0046777

GO:0061762

GO:0106310

GO:0140096

GO:1903599

HMNXSV003018639

HMNXSV003041113

Hs.108708.2.S1_3p_a_at

Hs.108708.3.S1_3p_at

ILMN_1743021

ILMN_2367638

PH_hs_0023571

TC12002061.hg

g4877950_3p_a_at

g5729894_3p_at

Participates

as a member of

p-CaMKK [cytosol] (Homo sapiens)

as a component of

p-CAMKK2:CALM1:4xCa2+ [cytosol] (Homo sapiens)

Other forms of this molecule

p-CAMKK2 [nucleoplasm]

CAMKK2 [nucleoplasm]

CAMKK2 [cytosol]

Inferred To

phospho-p-CAMKK2 [cytosol] (Caenorhabditis elegans)

phospho-p-CAMKK2 [cytosol] (Canis familiaris)

phospho-p-CAMKK2 [cytosol] (Mus musculus)

phospho-p-CAMKK2 [cytosol] (Rattus norvegicus)

phospho-p-CAMKK2 [cytosol] (Schizosaccharomyces pombe)

phospho-p-CAMKK2 [cytosol] (Sus scrofa)

phospho-CAMKK2 [cytosol] (Bos taurus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_016874190.1, XP_011536065.1, NP_006540.3, XP_016874191.1, NP_001257415.1, XP_016874187.1, NP_001257414.1, XP_016874193.1, NP_757364.1, XP_005253879.1, NP_705719.2, XP_005253881.1, NP_757365.1, XP_005253880.1, NP_757380.1, NP_705720.1, NP_757363.1

ZINC - World Drugs

KKCC2_HUMAN

Guide to Pharmacology - Targets

1957

OpenTargets

ENSG00000110931

ENSEMBL

ENST00000324774, ENSP00000312741, ENSP00000498824, ENST00000404169, ENST00000392474, ENST00000337174, ENST00000538733, ENST00000392473, ENSP00000336634, ENST00000652382, ENSP00000388273, ENST00000347034, ENSP00000321230, ENSP00000388368, ENSP00000384600, ENSP00000445944, ENST00000402834, ENST00000412367, ENSP00000376266, ENST00000446440, ENSP00000384591, ENSP00000376265

ZINC - FDA approved

KKCC2_HUMAN

ZINC - Substances

KKCC2_HUMAN

ZINC - Biogenic

KKCC2_HUMAN

ZINC target

Q96RR4

PRO

Q96RR4

GlyGen

Q96RR4

PDB

5VT1, 6Y6B, 6EF5, 6Y3O, 5YVB, 5YVC, 2ZV2, 6CMJ, 6BQP, 8TUC, 5UYJ, 5UY6, 5YV8, 6FEL, 6EWW, 6BKU, 6BQL, 6BRC, 5YVA, 6BQQ, 6Y8A, 6BLE, 5YV9, 6Y4K

ZINC - Investigational

KKCC2_HUMAN

HPA

ENSG00000110931-CAMKK2

Pharos - Targets

Q96RR4

ZINC - Predictions - Purchasable

KKCC2_HUMAN

HMDB Protein

HMDBP01346

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75147 OBSL1	1	OBSL1 [cytosol] (R-HSA-8955929)	0.643	3
UniProt:P54619 PRKAG1	2	PRKAG1 [cytosol] (R-HSA-380946) PRKAG1 [nucleoplasm] (R-HSA-2151202)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	3
UniProt:Q16539 MAPK14	7	MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.527	2
UniProt:P49773 HINT1	2	HINT1 [nucleoplasm] (R-HSA-9825679) Ac-K21,K30 HINT1 [nucleoplasm] (R-HSA-9825685)	0.527	2
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.527	2
UniProt:P62158 CALM			0.527	2