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p-S115 MAPKAPK5 [nucleoplasm]
Stable Identifier
R-HSA-5687026
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PRAK, MAP kinase-activated protein kinase 5, p38-regulated/activated protein kinase
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
PKA phosphorylates MAPKAPK5 (Homo sapiens)
p-S115 MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-S115 MAPKAPK5 translocates to the cytosol (Homo sapiens)
p-S115 MAPKAPK5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IW41 MAPKAPK5
Gene Names
MAPKAPK5, PRAK
Chain
chain:1-473
Reference Genes
BioGPS Gene:8550 MAPKAPK5
COSMIC (genes):MAPKAPK5 MAPKAPK5
CTD Gene:8550 MAPKAPK5
dbSNP Gene:8550 MAPKAPK5
ENSEMBL:ENSG00000089022 MAPKAPK5
HGNC:6889 MAPKAPK5
KEGG:hsa:8550 MAPKAPK5
Monarch:8550 MAPKAPK5
NCBI Gene:8550 MAPKAPK5
OMIM:606723 MAPKAPK5
UCSC:Q8IW41 MAPKAPK5
Reference Transcript
RefSeq:NM_139078.2 MAPKAPK5
RefSeq:NM_003668.3 MAPKAPK5
Participates
as an output of
PKA phosphorylates MAPKAPK5 (Homo sapiens)
as an input of
p-S115 MAPKAPK5 translocates to the cytosol (Homo sapiens)
Other forms of this molecule
p-T182 MAPKAPK5 [cytosol]
p-S115 MAPKAPK5 [cytosol]
p-T182-MAPKAPK5 [nucleoplasm]
MAPKAPK5 [nucleoplasm]
Inferred To
phospho-Mapkapk5 [nucleoplasm]
(Rattus norvegicus)
Homologues of p-S115 MAPKAPK5 [nucleoplasm]
(Plasmodium falciparum)
phospho-mapkapk5 [nucleoplasm]
(Danio rerio)
phospho-MAPKAPK5 [nucleoplasm]
(Bos taurus)
phospho-MAPKAPK5 [nucleoplasm]
(Sus scrofa)
phospho-p-S115 MAPKAPK5 [nucleoplasm]
(Gallus gallus)
phospho-p-S115 MAPKAPK5 [nucleoplasm]
(Mus musculus)
phospho-p-S115 MAPKAPK5 [nucleoplasm]
(Plasmodium falciparum)
Modified Residues
Name
O-phospho-L-serine at 115
Coordinate
115
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
Guide to Pharmacology - Targets
2096
ENSEMBL
ENSP00000449381
,
ENSP00000449667
,
ENST00000550735
,
ENSG00000089022
,
ENST00000551404
OpenTargets
ENSG00000089022
ZINC - Substances
MAPK5_HUMAN
ZINC - Biogenic
MAPK5_HUMAN
ZINC target
Q8IW41
PRO
Q8IW41
ZINC - Investigational
MAPK5_HUMAN
GeneCards
MAPKAPK5
HPA
ENSG00000089022-MAPKAPK5
Pharos - Targets
Q8IW41
ZINC - Predictions - Purchasable
MAPK5_HUMAN
HMDB Protein
HMDBP01196
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16659 MAPK6 gene
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
0.917
12
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.655
6
UniProt:P31152 MAPK4
4
p-S186 MAPK4 [nucleoplasm]
(R-HSA-5687022)
p-S186 MAPK4 [cytosol]
(R-HSA-5687023)
MAPK4 [cytosol]
(R-HSA-5686973)
MAPK4 [nucleoplasm]
(R-HSA-5686975)
0.643
5
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