Reactome | p-S,2T-MAPKAPK3 [nucleoplasm]

p-S,2T-MAPKAPK3 [nucleoplasm]

Stable Identifier

R-HSA-450359

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-MAP kinase-activated protein kinase 3, MAPKAPK3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q16644 MAPKAPK3

Gene Names

MAPKAPK3

Chain

chain:1-382

Reference Genes

BioGPS Gene:7867 MAPKAPK3

COSMIC (genes):MAPKAPK3 MAPKAPK3

CTD Gene:7867 MAPKAPK3

dbSNP Gene:7867 MAPKAPK3

ENSEMBL:ENSG00000114738 MAPKAPK3

ENSEMBL_homo_sapiens_GENE:ENSG00000114738.11 MAPKAPK3

HGNC:6888 MAPKAPK3

KEGG Gene (Homo sapiens):7867 MAPKAPK3

Monarch:7867 MAPKAPK3

NCBI Gene:7867 MAPKAPK3

OMIM:602130 MAPKAPK3

UCSC:Q16644 MAPKAPK3

Reference Transcript

Other Identifiers

11718076_at

11718077_s_at

1637_at

16941088

1991_s_at

202787_PM_s_at

202787_s_at

202788_PM_at

202788_at

2622913

2622915

2622916

2622918

2622919

2622923

2622924

2622926

2622930

2622931

2622933

2622935

2622936

2622937

2622940

2622941

2622942

2622943

2622945

39237_at

7867

8080013

91646_at

A_23_P314584

GE62221

GO:0000165

GO:0000166

GO:0002224

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0004708

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0007165

GO:0009931

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0023052

GO:0032496

GO:0034097

GO:0035556

GO:0036211

GO:0043226

GO:0044351

GO:0048010

GO:0051019

GO:0098542

GO:0106310

GO:0140096

HMNXSV003051788

ILMN_1732452

PH_hs_0023175

TC03000316.hg

U09578_at

g1256004_3p_a_at

g4758699_3p_at

Participates

as a member of

Active MAPKAP kinase [nucleoplasm] (Homo sapiens)

as a component of

phospho-MAPK p38:p-MAPKAPK3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MAPKAPK3 [cytosol]

MAPKAPK3 [nucleoplasm]

p-S,2T-MAPKAPK3 [cytosol]

Inferred To

phospho-MAPKAPK3 [nucleoplasm] (Gallus gallus)

phospho-p-S,2T-MAPKAPK3 [nucleoplasm] (Bos taurus)

phospho-p-S,2T-MAPKAPK3 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S,2T-MAPKAPK3 [nucleoplasm] (Danio rerio)

phospho-p-S,2T-MAPKAPK3 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S,2T-MAPKAPK3 [nucleoplasm] (Mus musculus)

phospho-p-S,2T-MAPKAPK3 [nucleoplasm] (Rattus norvegicus)

phospho-p-S,2T-MAPKAPK3 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001230855.1, NP_004626.1, NP_001230854.1

Guide to Pharmacology - Targets

2095

OpenTargets

ENSG00000114738

ZINC - Substances

MAPK3_HUMAN

ZINC target

Q16644

PRO

Q16644

PDB

3R1N, 3FHR, 3SHE, 3FXW, 7NRB

HPA

ENSG00000114738-MAPKAPK3

GeneCards

Q16644

Ensembl

ENSP00000478922, ENSG00000114738, ENSP00000396467, ENST00000446044, ENSP00000350639, ENST00000357955, ENST00000621469

Pharos - Targets

Q16644

ZINC - Predictions - Purchasable

MAPK3_HUMAN

Orphanet

25120

HMDB Protein

HMDBP11583

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.914	15
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.571	3
UniProt:P49137 MAPKAPK2	5	MAPKAPK2 [cytosol] (R-HSA-187743) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.527	3

Cite Us!