Reactome | RPS6KA4 [cytosol]

RPS6KA4 [cytosol]

Stable Identifier

R-HSA-772527

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ribosomal protein S6 kinase alpha-4, KS6A4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75676 RPS6KA4

Gene Names

RPS6KA4, MSK2

Chain

chain:1-772

Reference Genes

BioGPS Gene:8986 RPS6KA4

COSMIC (genes):RPS6KA4 RPS6KA4

CTD Gene:8986 RPS6KA4

dbSNP Gene:8986 RPS6KA4

ENSEMBL:ENSG00000162302 RPS6KA4

HGNC:10433 RPS6KA4

Monarch:8986 RPS6KA4

NCBI Gene:8986 RPS6KA4

OMIM:603606 RPS6KA4

UCSC:O75676 RPS6KA4

Reference Transcript

Other Identifiers

11721670_a_at

11721671_x_at

11748176_a_at

11752267_a_at

16726489

16726515

204632_PM_at

204632_at

3334572

3334573

3334574

3334575

3334576

3334577

3334578

3334579

3334580

3334581

3334582

3334583

3334584

3334585

3334586

3334587

3334588

3334590

3334591

3334592

3334594

3334595

3334596

41404_at

7941039

8986

A_23_P35791

GE55190

GO:0000287

GO:0001818

GO:0003824

GO:0004672

GO:0004674

GO:0004711

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006355

GO:0006468

GO:0006954

GO:0016740

GO:0032793

GO:0035175

GO:0035556

GO:0043226

GO:0043687

GO:0044022

GO:0045202

GO:0045944

GO:0046872

GO:0051092

GO:0070498

GO:0106310

GO:0140096

HMNXSV003016329

HMNXSV003022363

ILMN_1756204

PH_hs_0005868

TC11000599.hg

TC11000600.hg

g4506734_3p_at

Participates

as a member of

p90rsk [cytosol] (Homo sapiens)

Cross References

ZINC - World Drugs

KS6A4_HUMAN

Guide to Pharmacology - Targets

1524

ENSEMBL

ENST00000334205, ENSP00000333896

OpenTargets

ENSG00000162302

ZINC - FDA approved

KS6A4_HUMAN

ZINC - Substances

KS6A4_HUMAN

ZINC - Biogenic

KS6A4_HUMAN

ZINC target

O75676

PRO

O75676

GlyGen

O75676

ZINC - Investigational

KS6A4_HUMAN

HPA

ENSG00000162302-RPS6KA4

Pharos - Targets

O75676

ZINC - Predictions - Purchasable

KS6A4_HUMAN

HMDB Protein

HMDBP01227

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.829	9
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.527	3

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