Reactome | p-S189,T193-MAP2K3 [cytosol]

p-S189,T193-MAP2K3 [cytosol]

Stable Identifier

R-HSA-167955

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S189,T193-MKK3, Mitogen-activated protein kinase kinase 3 (phosphorylated)

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P46734 MAP2K3

Gene Names

MAP2K3, MEK3, MKK3, PRKMK3, SKK2

Chain

chain:1-347

Reference Genes

BioGPS Gene:5606 MAP2K3

COSMIC (genes):MAP2K3 MAP2K3

CTD Gene:5606 MAP2K3

dbSNP Gene:5606 MAP2K3

ENSEMBL:ENSG00000034152 MAP2K3

HGNC:6843 MAP2K3

KEGG Gene (Homo sapiens):5606 MAP2K3

Monarch:5606 MAP2K3

NCBI Gene:5606 MAP2K3

OMIM:602315 MAP2K3

UCSC:P46734 MAP2K3

Reference Transcript

Other Identifiers

0004590114

0007100154

0007100750

11742801_a_at

1622_at

16832268

18548

2075_s_at

207667_s_at

215498_s_at

215499_at

3714730

3714731

3714733

3714735

3714744

3714745

3714748

3714749

3714751

3714752

3714753

3714754

3714755

3714758

3714759

3714764

3714766

3714767

3714768

3714769

3714770

3714772

5606

8005707

A_14_P109219

A_23_P118427

A_24_P296698

AAB40652

AAB40653

AAC41718

AAH32478

AB451226

AB451349

AK093838

AK315505

BAA13248

BAG37889

BAG52769

BAG70040

BAG70163

BC032478

CAB018548

CAG38752

CCDS11217

CCDS11218

CR536514

D87116

D87116_at

E9PMA8

E9PRZ0

ENSG00000034152

ENSP00000319139

ENSP00000345083

ENSP00000355081

ENSP00000478619

ENST00000316920

ENST00000316920.10

ENST00000342679

ENST00000342679.8

ENST00000361818

ENST00000361818.9

ENST00000613338

ENST00000613338.4

EntrezGene:5606

EntrezGene:MAP2K3

g4506098_3p_a_at

GE594548

GE62082

GO:0000165

GO:0000166

GO:0000187

GO:0000278

GO:0003013

GO:0003674

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0006950

GO:0006954

GO:0007049

GO:0007165

GO:0007346

GO:0008150

GO:0009058

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019899

GO:0019901

GO:0023014

GO:0031098

GO:0032147

GO:0034641

GO:0035924

GO:0038066

GO:0040011

GO:0042035

GO:0043167

GO:0043226

GO:0043536

GO:0045860

GO:0045893

GO:0048870

GO:0060048

HGNC:6843

Hs.180533.2.S1_3p_a_at

Hs.180533.2.S1_3p_x_at

ILMN_1668909

ILMN_1680777

ILMN_1790534

IPR000719

IPR008271

IPR011009

IPR017441

J3KRV4

J3QL77

J3QR49

L36719

MAP2K3

MAP2K3-201

MAP2K3-202

MAP2K3-203

MAP2K3-214

MIM:602315

NM_001316332

NM_002756

NM_145109

NP_001303261

NP_002747

NP_659731

PF00069

PH_hs_0010680

Q6FI23

SM00220

TC17000297.hg

TC17002123.hg

U66839

U66840

UPI000002AE41

UPI000012F48C

X6RB39

XM_005256723

XM_011523958

XM_011523959

XM_017024857

XM_017024858

XM_017024859

XP_005256780

XP_011522260

XP_011522261

XP_016880346

XP_016880347

XP_016880348

Participant Of

hasMember

p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol]

Other forms of this molecule

MAP2K3 [cytosol]

p-S189,T193-MAP2K3 [nucleoplasm]

Inferred To

phospho-Map2k3 [cytosol] (Mus musculus)

phospho-Map2k3 [cytosol] (Rattus norvegicus)

phospho-sek-4 [cytosol] (Caenorhabditis elegans)

phospho-sek-5 [cytosol] (Caenorhabditis elegans)

phospho-p-S189,T193-MAP2K3 [cytosol] (Dictyostelium discoideum)

phospho-p-S189,T193-MAP2K3 [cytosol] (Plasmodium falciparum)

phospho-p-S189,T193-MAP2K3 [cytosol] (Xenopus tropicalis)

phospho-MAP2K3 [cytosol] (Bos taurus)

phospho-MAP2K3 [cytosol] (Canis familiaris)

Homologues of p-S189,T193-MAP2K3 [cytosol] (Caenorhabditis elegans)

phospho-lic [cytosol] (Drosophila melanogaster)

phospho-PBS2 [cytosol] (Saccharomyces cerevisiae)

phospho-wis1 [cytosol] (Schizosaccharomyces pombe)

phospho-map2k6 [cytosol] (Danio rerio)

phospho-mek-1 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 189

Coordinate

189

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 193

Coordinate

193

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_016880347.1, NP_001303261.1, XP_016880348.1, NP_002747.2, XP_011522261.1, NP_659731.1, XP_005256780.1

ZINC - World Drugs

MP2K3_HUMAN

OpenTargets

ENSG00000034152

ZINC - FDA approved

MP2K3_HUMAN

ZINC - Substances

MP2K3_HUMAN

ZINC - Biogenic

MP2K3_HUMAN

ZINC target

P46734

PRO

P46734

ZINC - Investigational

MP2K3_HUMAN

GeneCards

P46734

HPA

ENSG00000034152-MAP2K3

Ensembl

ENST00000342679, ENST00000361818, ENSP00000345083, ENSP00000478619, ENST00000613338, ENSP00000355081, ENSP00000319139, ENST00000316920, ENSG00000034152

ZINC - Predictions - Purchasable

MP2K3_HUMAN

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.757	6
UniProt:Q16539 MAPK14	7	MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [nucleoplasm] (R-HSA-446223) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.669	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.589	5

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