Reactome | p-T222,S272-MAPKAPK2 [nucleoplasm]

p-T222,S272-MAPKAPK2 [nucleoplasm]

Stable Identifier

R-HSA-199936

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S272,T222-MAPKAPK2, Phospho-MAP kinase-activated protein kinase 2, MKK2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49137 MAPKAPK2

Gene Names

MAPKAPK2

Chain

chain:1-400

Reference Genes

BioGPS Gene:9261 MAPKAPK2

COSMIC (genes):MAPKAPK2 MAPKAPK2

CTD Gene:9261 MAPKAPK2

dbSNP Gene:9261 MAPKAPK2

ENSEMBL:ENSG00000162889.11 MAPKAPK2

HGNC:6887 MAPKAPK2

KEGG Gene (Homo sapiens):9261 MAPKAPK2

Monarch:9261 MAPKAPK2

NCBI Gene:9261 MAPKAPK2

OMIM:602006 MAPKAPK2

UCSC:P49137 MAPKAPK2

Reference Transcript

Other Identifiers

11719368_s_at

11730896_a_at

1439_s_at

1469_at

16676643

201460_PM_at

201460_at

201461_PM_s_at

201461_s_at

215050_PM_x_at

215050_x_at

2376923

2376924

2376925

2376926

2376949

2376950

2376951

2376953

2376954

2376956

2376957

2376959

2376962

2376964

2376965

2376966

2376967

2376968

36179_at

36180_s_at

7909236

9261

A_14_P129763

A_23_P201483

A_23_P350467

GO:0000165

GO:0000166

GO:0002224

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0005515

GO:0005516

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006468

GO:0006691

GO:0006954

GO:0006974

GO:0009931

GO:0016071

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0023052

GO:0032496

GO:0032675

GO:0032680

GO:0032760

GO:0034097

GO:0035556

GO:0035924

GO:0036211

GO:0038066

GO:0043226

GO:0043488

GO:0044351

GO:0046777

GO:0048010

GO:0048255

GO:0048839

GO:0048856

GO:0050896

GO:0051019

GO:0060907

GO:0070062

GO:0070935

GO:0106310

GO:0140096

GO:1900034

HMNXSV003000707

Hs.75074.0.A2_3p_at

ILMN_1656144

ILMN_1774844

PH_hs_0004270

TC01001727.hg

U12779_at

X75346_s_at

g10863900_3p_a_at

Other forms of this molecule

MAPKAPK2 [cytosol]

p-S272,T222,T334-MAPKAPK2 [cytosol]

p-T222,S272,T334-MAPKAPK2 [nucleoplasm]

MAPKAPK2 [nucleoplasm]

Inferred To

phospho-MAPKAPK2 [nucleoplasm] (Gallus gallus)

Homologues of p-T222,S272-MAPKAPK2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T222,S272-MAPKAPK2 [nucleoplasm] (Bos taurus)

phospho-p-T222,S272-MAPKAPK2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T222,S272-MAPKAPK2 [nucleoplasm] (Danio rerio)

phospho-p-T222,S272-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T222,S272-MAPKAPK2 [nucleoplasm] (Mus musculus)

phospho-p-T222,S272-MAPKAPK2 [nucleoplasm] (Rattus norvegicus)

phospho-p-T222,S272-MAPKAPK2 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 222

Coordinate

222

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 272

Coordinate

272

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_116584.2, NP_004750.1

ZINC - World Drugs

MAPK2_HUMAN

Guide to Pharmacology - Targets

2094

OpenTargets

ENSG00000162889

ZINC - Substances

MAPK2_HUMAN

ZINC target

P49137

ZINC - Biogenic

MAPK2_HUMAN

PRO

P49137

PDB

3GOK, 6T8X, 2OZA, 2JBO, 1NXK, 3KA0, 3R2B, 3FYJ, 2PZY, 3M2W, 2OKR, 3FYK, 4TYH, 3KGA, 1KWP, 3FPM, 3R2Y, 7NRY, 3WI6, 2JBP, 3R30, 3KC3, 2P3G, 2ONL, 1NY3, 3M42, 6TCA, 3A2C

ZINC - Investigational

MAPK2_HUMAN

ZINC - Metabolites

MAPK2_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000162889-MAPKAPK2

GeneCards

P49137

Ensembl

ENSP00000294981, ENSP00000356070, ENSG00000162889, ENST00000294981, ENST00000367103

Pharos - Targets

P49137

ZINC - Predictions - Purchasable

MAPK2_HUMAN

HMDB Protein

HMDBP02904

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.915	10
UniProt:Q00613 HSF1	11	p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) HSF1 [cytosol] (R-HSA-3371452)	0.602	5
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.571	3
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.488	2