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MAPKAPK3 [cytosol]
Stable Identifier
R-HSA-187764
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MAP kinase-activated protein kinase 3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)
MAPKAP kinase [cytosol] (Homo sapiens)
MAPKAPK3 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)
MAPKAP kinase [cytosol] (Homo sapiens)
MAPKAPK3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16644 MAPKAPK3
Gene Names
MAPKAPK3
Chain
chain:1-382
Reference Genes
BioGPS Gene:7867 MAPKAPK3
COSMIC (genes):MAPKAPK3 MAPKAPK3
CTD Gene:7867 MAPKAPK3
dbSNP Gene:7867 MAPKAPK3
ENSEMBL:ENSG00000114738 MAPKAPK3
ENSEMBL_homo_sapiens_GENE:ENSG00000114738.11 MAPKAPK3
HGNC:6888 MAPKAPK3
KEGG Gene (Homo sapiens):7867 MAPKAPK3
Monarch:7867 MAPKAPK3
NCBI Gene:7867 MAPKAPK3
OMIM:602130 MAPKAPK3
UCSC:Q16644 MAPKAPK3
Reference Transcript
RefSeq:NM_004635.4 MAPKAPK3
RefSeq:NM_001243926.1 MAPKAPK3
RefSeq:NM_001243925.1 MAPKAPK3
Other Identifiers
11718076_at
11718077_s_at
1637_at
16941088
1991_s_at
202787_PM_s_at
202787_s_at
202788_PM_at
202788_at
2622913
2622915
2622916
2622918
2622919
2622923
2622924
2622926
2622930
2622931
2622933
2622935
2622936
2622937
2622940
2622941
2622942
2622943
2622945
39237_at
7867
8080013
91646_at
A_23_P314584
GE62221
GO:0000165
GO:0000166
GO:0002224
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0004708
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006468
GO:0007165
GO:0009931
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0023052
GO:0032496
GO:0034097
GO:0035556
GO:0036211
GO:0043226
GO:0044351
GO:0048010
GO:0051019
GO:0098542
GO:0106310
GO:0140096
HMNXSV003051788
ILMN_1732452
PH_hs_0023175
TC03000316.hg
U09578_at
g1256004_3p_a_at
g4758699_3p_at
Participates
as a member of
MAPKAP kinase [cytosol] (Homo sapiens)
Other forms of this molecule
MAPKAPK3 [nucleoplasm]
p-S,2T-MAPKAPK3 [nucleoplasm]
p-S,2T-MAPKAPK3 [cytosol]
Inferred To
MAPKAPK3 [cytosol]
(Bos taurus)
MAPKAPK3 [cytosol]
(Caenorhabditis elegans)
MAPKAPK3 [cytosol]
(Danio rerio)
MAPKAPK3 [cytosol]
(Drosophila melanogaster)
MAPKAPK3 [cytosol]
(Gallus gallus)
MAPKAPK3 [cytosol]
(Mus musculus)
MAPKAPK3 [cytosol]
(Plasmodium falciparum)
MAPKAPK3 [cytosol]
(Rattus norvegicus)
MAPKAPK3 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001230855.1
,
NP_001230854.1
,
NP_004626.1
Guide to Pharmacology - Targets
2095
OpenTargets
ENSG00000114738
ZINC - Substances
MAPK3_HUMAN
ZINC target
Q16644
PRO
Q16644
PDB
7NRB
,
3FHR
,
3R1N
,
3SHE
,
3FXW
HPA
ENSG00000114738-MAPKAPK3
GeneCards
Q16644
Ensembl
ENST00000446044
,
ENST00000357955
,
ENSP00000478922
,
ENSP00000350639
,
ENST00000621469
,
ENSP00000396467
,
ENSG00000114738
Pharos - Targets
Q16644
ZINC - Predictions - Purchasable
MAPK3_HUMAN
Orphanet
25120
HMDB Protein
HMDBP11583
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16539 MAPK14
7
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.914
15
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.571
3
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.527
3
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