Reactome | p-T182 MAPKAPK5 [cytosol]

p-T182 MAPKAPK5 [cytosol]

Stable Identifier

R-HSA-5687004

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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External Reference Information

External Reference

UniProt:Q8IW41 MAPKAPK5

Gene Names

MAPKAPK5, PRAK

Chain

chain:1-473

Reference Genes

COSMIC (genes):MAPKAPK5 MAPKAPK5

dbSNP Gene:8550 MAPKAPK5

ENSEMBL:ENSG00000089022 MAPKAPK5

Participates

as an input of

as a component of

as a member of

p-S MAPKAPK5 [cytosol] (Homo sapiens)

as an output of

p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Homo sapiens)

Other forms of this molecule

p-S115 MAPKAPK5 [cytosol]

p-S115 MAPKAPK5 [nucleoplasm]

p-T182-MAPKAPK5 [nucleoplasm]

MAPKAPK5 [nucleoplasm]

Inferred To

Homologues of p-T182 MAPKAPK5 [cytosol] (Plasmodium falciparum)

phospho-Mapkapk5 [cytosol] (Rattus norvegicus)

phospho-p-T182 MAPKAPK5 [cytosol] (Gallus gallus)

phospho-p-T182 MAPKAPK5 [cytosol] (Mus musculus)

phospho-p-T182 MAPKAPK5 [cytosol] (Plasmodium falciparum)

phospho-MAPKAPK5 [cytosol] (Bos taurus)

phospho-MAPKAPK5 [cytosol] (Sus scrofa)

phospho-mapkapk5 [cytosol] (Danio rerio)

Modified Residues

Name

O-phospho-L-threonine at 182

Coordinate

182

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16659 MAPK6	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.917	12
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.655	6
UniProt:P31152 MAPK4	4	p-S186 MAPK4 [nucleoplasm] (R-HSA-5687022) p-S186 MAPK4 [cytosol] (R-HSA-5687023) MAPK4 [cytosol] (R-HSA-5686973) MAPK4 [nucleoplasm] (R-HSA-5686975)	0.643	5
UniProt:Q16539 MAPK14	7	p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [cytosol] (R-HSA-428933) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280)	0.547	2

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