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p-S463,S465-SMAD1 [nucleoplasm]
Stable Identifier
R-HSA-201483
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-R-SMAD1, Mothers against decapentaplegic homolog 1, SMA1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
RUNX2 and SMAD1 complex binds the SMAD6 gene promoter (Homo sapiens)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4:SMAD6 gene [nucleoplasm] (Homo sapiens)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
RUNX2 binds SMAD1 in the nucleus (Homo sapiens)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4:SMAD6 gene [nucleoplasm] (Homo sapiens)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGF-beta family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm] (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15797 SMAD1
Gene Names
SMAD1, BSP1, MADH1, MADR1
Chain
chain:1-465
Reference Genes
BioGPS Gene:4086 SMAD1
COSMIC (genes):SMAD1 SMAD1
CTD Gene:4086 SMAD1
dbSNP Gene:4086 SMAD1
ENSEMBL:ENSG00000170365 SMAD1
ENSEMBL_homo_sapiens_GENE:ENSG00000170365 SMAD1
HGNC:6767 SMAD1
KEGG Gene (Homo sapiens):4086 SMAD1
Monarch:4086 SMAD1
NCBI Gene:4086 SMAD1
OMIM:601595 SMAD1
UCSC:Q15797 SMAD1
Reference Transcript
RefSeq:XM_011531963.1 SMAD1
RefSeq:XM_011531962.1 SMAD1
RefSeq:XM_006714217.2 SMAD1
RefSeq:XM_011531961.1 SMAD1
RefSeq:NM_005900.2 SMAD1
RefSeq:XM_005262992.3 SMAD1
RefSeq:XM_011531964.1 SMAD1
RefSeq:NM_001003688.1 SMAD1
Other Identifiers
11747501_a_at
1325_at
1KHU
210993_s_at
2746121
2746125
2746126
2746127
2746130
2746131
2746138
2746141
2746142
2746144
2746147
2746150
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
37280_at
3Q47
3Q4A
4086
5389
8097657
A_14_P103768
A_23_P212870
AAB06852
AAC50493
AAC50621
AAC50790
AAH01878
AAP36050
AK293055
AL117396
BAF85744
BC001878
BT007386
CAB005389
CAB55898
CCDS3765
CH471056
D6RAY1
D6RBH9
D6RD62
D6RDN7
D6REQ3
EAX05037
EAX05038
EAX05039
EAX05040
ENSG00000170365
ENSP00000305769
ENSP00000377652
ENSP00000426568
ENST00000302085
ENST00000394092
ENST00000515385
EntrezGene:4086
g1332713_3p_a_at
GE59266
GO:0000003
GO:0000165
GO:0000978
GO:0000981
GO:0001077
GO:0001657
GO:0001710
GO:0002051
GO:0003674
GO:0003677
GO:0003700
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005637
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006366
GO:0006412
GO:0006464
GO:0006468
GO:0006950
GO:0006954
GO:0007165
GO:0007179
GO:0007183
GO:0007276
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0009790
GO:0009880
GO:0010628
GO:0016021
GO:0016579
GO:0017151
GO:0019899
GO:0019901
GO:0022607
GO:0030154
GO:0030509
GO:0030618
GO:0030901
GO:0030902
GO:0031053
GO:0032991
GO:0034641
GO:0040007
GO:0042592
GO:0042802
GO:0042803
GO:0043167
GO:0043226
GO:0043565
GO:0045669
GO:0045944
GO:0046872
GO:0046982
GO:0048646
GO:0048856
GO:0051216
GO:0060038
GO:0060348
GO:0060395
GO:0061036
GO:0065003
GO:0070410
GO:0070411
GO:0070878
GO:0071141
GO:0071407
GO:0071773
GO:1901522
GO:1902895
GO:1903672
HGNC:6767
ILMN_1670540
ILMN_1705392
IPR001132
IPR003619
IPR008984
IPR013019
IPR013790
IPR017855
IPR036578
MIM:601595
NM_001003688
NM_005900
NP_001003688
NP_001341740
NP_001341741
NP_001341742
NP_001341743
NP_001341745
NP_001341746
NP_005891
PF03165
PF03166
PH_hs_0024460
SM00523
SM00524
SMAD1
SMAD1-201
SMAD1-202
SMAD1-215
U54826
U57456
U59423
U59423_at
U59912
uc003ikc.4
uc003ikd.4
uc010iov.4
UPI0000135A76
XM_005262992
XM_006714217
XM_011531961
XM_011531962
XM_011531963
XM_011531964
XP_005263049
XP_006714280
XP_011530263
XP_011530264
XP_011530265
XP_011530266
Participant Of
hasMember
Phospho-R-SMAD1/5/9 [nucleoplasm]
hasComponent
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm]
Other forms of this molecule
Ub-SMAD1 [cytosol]
SMAD1 [cytosol]
p-S463,S465-SMAD1 [cytosol]
Inferred To
Ghost homologue of p-S463,S465-SMAD1 [nucleoplasm] (Danio rerio)
Ghost homologue of p-S463,S465-SMAD1 [nucleoplasm] (Drosophila melanogaster)
Ghost homologue of p-S463,S465-SMAD1 [nucleoplasm] (Gallus gallus)
Ghost homologue of p-S463,S465-SMAD1 [nucleoplasm] (Mus musculus)
Ghost homologue of p-S463,S465-SMAD1 [nucleoplasm] (Rattus norvegicus)
Ghost homologue of p-S463,S465-SMAD1 [nucleoplasm] (Xenopus tropicalis)
Homologues of p-S463,S465-SMAD1 [nucleoplasm] (Sus scrofa)
phospho-p-S463,S465-SMAD1 [nucleoplasm] (Bos taurus)
phospho-p-S463,S465-SMAD1 [nucleoplasm] (Canis familiaris)
phospho-p-S463,S465-SMAD1 [nucleoplasm] (Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 463
Coordinate
463
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 465
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_005263049.1
,
NP_001003688.1
,
XP_011530263.1
,
XP_011530265.1
,
XP_006714280.1
,
NP_005891.1
,
XP_011530264.1
,
XP_011530266.1
OpenTargets
ENSG00000170365
GeneCards
Q15797
DOCK Blaster
3Q47
,
3Q4A
,
1KHU
PRO
Q15797
PDB
2LAW
,
2LAY
,
2LB1
,
2LB0
,
3Q4A
,
1KHU
,
3Q47
,
2LAX
,
2LAZ
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13485 SMAD4
18
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 K428R [cytosol]
(R-HSA-3311001)
SMAD4 [nucleoplasm]
(R-HSA-177103)
SMAD4 [cytosol]
(R-HSA-170862)
RibC-SMAD4 [nucleoplasm]
(R-HSA-2187323)
SMAD4 R361S [cytosol]
(R-HSA-3310994)
SMAD4 R361G [cytosol]
(R-HSA-3310993)
SMAD4 R515* [cytosol]
(R-HSA-3311012)
0.909
9
UniProt:Q9HAU4 SMURF2
2
SMURF2 [cytosol]
(R-HSA-173537)
SMURF2 [nucleoplasm]
(R-HSA-178202)
0.729
4
UniProt:P17844 DDX5
3
SUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
DDX5 [nucleoplasm]
(R-HSA-3900136)
SUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.612
4
UniProt:P49841 GSK3B
4
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [cytosol]
(R-HSA-2997551)
GSK3B [nucleoplasm]
(R-HSA-2022823)
0.609
2
UniProt:P10275 AR
4
SUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
0.602
6
UniProt:Q9HCE7 SMURF1
2
SMURF1 [cytosol]
(R-HSA-975972)
SMURF1 [nucleoplasm]
(R-HSA-3004548)
0.573
2
UniProt:O43541 SMAD6
1
SMAD6 [cytosol]
(R-HSA-3006350)
0.567
4
UniProt:P46937 YAP1
7
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
YAP1 [nucleoplasm]
(R-HSA-1253322)
YAP1 [cytosol]
(R-HSA-1253345)
0.544
3
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