Reactome | Prosbeta7 [nucleoplasm]

Prosbeta7 [nucleoplasm]

Stable Identifier

R-DME-174343

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

PSMB4, Q9VNA5

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G1/S DNA Damage Checkpoints (Drosophila melanogaster)
    - p53-Independent G1/S DNA Damage Checkpoint (Drosophila melanogaster)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP inner ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosbeta7 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Cyclin E associated events during G1/S transition (Drosophila melanogaster)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP inner ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosbeta7 [nucleoplasm] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP inner ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosbeta7 [nucleoplasm] (Drosophila melanogaster)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP inner ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosbeta7 [nucleoplasm] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
      - SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP inner ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosbeta7 [nucleoplasm] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to chemical stress (Drosophila melanogaster)
    - KEAP1-NFE2L2 pathway (Drosophila melanogaster)
      - Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP inner ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosbeta7 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX2 (Drosophila melanogaster)
      - Regulation of RUNX2 expression and activity (Drosophila melanogaster)
        
        26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP inner ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosbeta7 [nucleoplasm] (Drosophila melanogaster)
    - Transcriptional regulation by RUNX3 (Drosophila melanogaster)
      - Regulation of RUNX3 expression and activity (Drosophila melanogaster)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        20S core particle [nucleoplasm] (Drosophila melanogaster)
        
        20S CP inner ring [nucleoplasm] (Drosophila melanogaster)
        
        Prosbeta7 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VNA5 Prosbeta7

Gene Names

Prosbeta7, Prosb4, Prosbeta4, CG12000

Chain

chain:1-268

Reference Genes

BioGPS Gene:40639 Prosbeta7

CTD Gene:40639 Prosbeta7

KEGG:dme:Dmel_CG12000 Prosbeta7

Monarch:40639 Prosbeta7

NCBI Gene:40639 Prosbeta7

UCSC:Q9VNA5 Prosbeta7

Reference Transcript

Other Identifiers

154275_at

1630851_s_at

40639

GO:0000502

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0007098

GO:0019774

GO:0030163

GO:0043161

GO:0051603

Participates

as a component of

20S CP inner ring [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

CG12000 [nucleoplasm]

CG12000 [cytosol]

Prosbeta7 [cytosol]

Inferred From

PSMB4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_649529.1, NP_730922.1

ENSEMBL

FBgn0250746, FBpp0078449, FBtr0078805, FBpp0078448, FBtr0078806

FlyBase

FBgn0250746

PRO

Q9VNA5

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40301 Prosalpha2	7	PROS25 [nucleoplasm] (R-DME-216177) PROS25 [cytosol] (R-DME-206278) Prosalpha2 [secretory granule lumen] (R-DME-6803329) Prosalpha2 [extracellular region] (R-DME-6806506) Prosalpha2 [ficolin-1-rich granule lumen] (R-DME-6803285) Prosalpha2 [nucleoplasm] (R-DME-174345) Prosalpha2 [cytosol] (R-DME-68726)	0.547	3
UniProt:Q9V3H2 Rpn11	7	RPN11 [nucleoplasm] (R-DME-216278) RPN11 [cytosol] (R-DME-205893) PSMD14 [secretory granule lumen] (R-DME-6800926) PSMD14 [extracellular region] (R-DME-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-DME-6800419) PSMD14 [nucleoplasm] (R-DME-174329) PSMD14 [cytosol] (R-DME-68722)	0.547	2
UniProt:Q7K148	6	Prosbeta5 [cytosol] (R-DME-9908135) Prosbeta5 [cytosol] (R-DME-9908126) Prosbeta5 [cytosol] (R-DME-9908127) Prosbeta5 [cytosol] (R-DME-68762) Prosbeta5 [nucleoplasm] (R-DME-174344) Prosbeta5 [cytosol] (R-DME-68753)	0.547	3
UniProt:Q9XYN7 Prosbeta3	4	PROSbeta3 [nucleoplasm] (R-DME-216230) PROSbeta3 [cytosol] (R-DME-206158) Prosbeta3 [nucleoplasm] (R-DME-174341) Prosbeta3 [cytosol] (R-DME-68747)	0.547	2
UniProt:Q9VJJ0 CG17331	4	CG17331 [nucleoplasm] (R-DME-216116) CG17331 [cytosol] (R-DME-206285) Prosbeta4 [nucleoplasm] (R-DME-174335) Prosbeta4 [cytosol] (R-DME-68744)	0.547	2