Reactome | GABARAPL1 [autophagosome membrane]

GABARAPL1 [autophagosome membrane]

Stable Identifier

R-HSA-5683637

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

autophagosome membrane

Synonyms

Gamma-aminobutyric acid receptor-associated protein-like 1, GBRL1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H0R8 GABARAPL1

Gene Names

GABARAPL1, GEC1

Chain

chain:1-116, propeptide:-

Reference Genes

BioGPS Gene:23710 GABARAPL1

COSMIC (genes):GABARAPL1 GABARAPL1

CTD Gene:23710 GABARAPL1

dbSNP Gene:23710 GABARAPL1

ENSEMBL:ENSG00000139112 GABARAPL1

HGNC:4068 GABARAPL1

KEGG:hsa:23710 GABARAPL1

Monarch:23710 GABARAPL1

NCBI Gene:23710 GABARAPL1

OMIM:607420 GABARAPL1

UCSC:Q9H0R8 GABARAPL1

Reference Transcript

Other Identifiers

11738986_a_at

11738987_x_at

11758023_x_at

11760119_at

16748304

208868_3p_s_at

208868_PM_s_at

208868_s_at

208869_PM_s_at

208869_s_at

211458_PM_s_at

211458_s_at

23710

3404637

3404638

3404639

3404640

3404641

3404642

3404643

3404644

3404645

3404646

3404647

3404648

3404650

3404653

3404654

3404655

3404656

3404657

3404658

3404659

35785_at

3638875

7953943

A_14_P125630

A_23_P162640

A_24_P4816

GE80327

GO:0000045

GO:0000421

GO:0000422

GO:0005515

GO:0005543

GO:0005737

GO:0005739

GO:0005773

GO:0005776

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0005874

GO:0005975

GO:0006091

GO:0006914

GO:0006995

GO:0007005

GO:0008092

GO:0008289

GO:0008429

GO:0016020

GO:0030659

GO:0030957

GO:0031410

GO:0031625

GO:0043226

GO:0048487

GO:0050811

GO:0061723

GO:0097352

HMNXSV003008661

HMNXSV003020433

Hs.282654.0.A1_3p_a_at

Hs.282654.0.A1_3p_s_at

ILMN_2151281

PH_hs_0032727

TC12000159.hg

g13241283_3p_s_at

g13375570_3p_a_at

Participates

as a member of

LC3 family [autophagosome membrane] (Homo sapiens)

Other forms of this molecule

GABARAPL1 [cytosol]

GABARAPL1(1-117) [cytosol]

Inferred To

GABARAPL1 [autophagosome membrane] (Bos taurus)

GABARAPL1 [autophagosome membrane] (Gallus gallus)

GABARAPL1 [autophagosome membrane] (Sus scrofa)

wu:fj43a09 [autophagosome membrane] (Danio rerio)

Atg8a [autophagosome membrane] (Drosophila melanogaster)

atg8 [autophagosome membrane] (Dictyostelium discoideum)

atg8 [autophagosome membrane] (Schizosaccharomyces pombe)

lgg-1 [autophagosome membrane] (Caenorhabditis elegans)

ATG8 [autophagosome membrane] (Saccharomyces cerevisiae)

Homologues of GABARAP [autophagosome membrane] (Danio rerio)

Homologues of GABARAP [autophagosome membrane] (Dictyostelium discoideum)

gabarapa [autophagosome membrane] (Danio rerio)

Gabarapl1 [autophagosome membrane] (Mus musculus)

Gabarapl1 [autophagosome membrane] (Rattus norvegicus)

GABARAP [autophagosome membrane] (Dictyostelium discoideum)

GABARAP [autophagosome membrane] (Plasmodium falciparum)

Atg8b [autophagosome membrane] (Drosophila melanogaster)

Homologues of GABARAPL1 [autophagosome membrane] (Drosophila melanogaster)

gabarapl1 [autophagosome membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_005253401.1, NP_113600.1

OpenTargets

ENSG00000139112

ENSEMBL

ENST00000266458, ENST00000543602, ENSP00000266458, ENSP00000444186, ENST00000545887, ENSP00000445857, ENSP00000411256, ENST00000421801

HPA

ENSG00000139112-GABARAPL1

PRO

Q9H0R8

Pharos - Targets

Q9H0R8

GlyGen

Q9H0R8

HMDB Protein

HMDBP10820

PDB

7AA9, 6YOO, 6HOI, 5LXI, 5DPT, 7JHX, 7AA7, 2L8J, 6HOL, 2R2Q, 5LXH

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.953	18
UniProt:Q3MII6 TBC1D25	1	TBC1D25 [autophagosome] (R-HSA-8854607)	0.742	5
UniProt:Q92636 NSMAF	1	NSMAF [cytosol] (R-HSA-5626992)	0.723	8
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.704	4
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.646	3
UniProt:P41145 OPRK1	1	OPRK1 [plasma membrane] (R-HSA-374286)	0.633	5
UniProt:Q96A56 TP53INP1	1	TP53INP1 [nucleoplasm] (R-HSA-3215226)	0.601	9
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.591	4
UniProt:Q9Z2F7	1	Bnip3l [mitochondrial outer membrane] (R-MMU-6798001)	0.571	4
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.556	3
UniProt:O60238 BNIP3L	1	BNIP3L [mitochondrial outer membrane] (R-HSA-6798001)	0.556	3
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.544	2
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.544	2
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.544	2
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.525	6
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.525	2
UniProt:Q9NT62 ATG3	8	CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) ATG3 [cytosol] (R-HSA-5671860)	0.525	3
UniProt:Q9Y3P9 RABGAP1	1	RABGAP1 [cytosol] (R-HSA-8854144)	0.499	2
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.488	2

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