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Metabolism of folate and pterines
Stable Identifier
R-HSA-196757
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Metabolism of folate and pterines (Homo sapiens)
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Folates are essential cofactors that provide one-carbon moieties in various states of reduction for biosynthetic reactions. Processes annotated here include transport reactions by which folates are taken up by cells and moved intracellularly, folate conjugation with glutamate (required for folate retention within a cell), and some of the key reactions in the generation of reduced folates and one-carbon derivatives of folate.
Literature References
PubMed ID
Title
Journal
Year
10466189
Folate and vitamin B12
Scott, JM
Proc Nutr Soc
1999
11001804
Folic acid: nutritional biochemistry, molecular biology, and role in disease processes
Lucock, M
Mol Genet Metab
2000
Participants
Events
FOLR2 binds FOLA
(Homo sapiens)
FOLR2 transports FOLA from extracellular region to cytosol
(Homo sapiens)
SLC46A1 transports FOLA from extracellular region to cytosol
(Homo sapiens)
Cytosolic folate export across the plasma membrane
(Homo sapiens)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol
(Homo sapiens)
DHFR2 reduces FOLA to DHF
(Homo sapiens)
DHFR dimer reduces FOLA to DHF
(Homo sapiens)
DHFR dimer binds DHFR inhibitors
(Homo sapiens)
DHF is reduced to tetrahydrofolate (THF)
(Homo sapiens)
FPGS-2 transforms THF to THFPG
(Homo sapiens)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG
(Homo sapiens)
SLC25A32 transports THF from cytosol to mitochondrial matrix
(Homo sapiens)
SLC25A32 transports THF from mitochondrial matrix to cytosol
(Homo sapiens)
Mitochondrial FPGS-1 transforms THF to THFPG
(Homo sapiens)
PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
(Homo sapiens)
MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF
(Homo sapiens)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG
(Homo sapiens)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG
(Homo sapiens)
MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG
(Homo sapiens)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG
(Homo sapiens)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG
(Homo sapiens)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine
(Homo sapiens)
5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+
(Homo sapiens)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
(Homo sapiens)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG
(Homo sapiens)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF
(Homo sapiens)
MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF
(Homo sapiens)
ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG
(Homo sapiens)
MTHFD1L transforms 10-formyl-THF to HCOOH and THF
(Homo sapiens)
HCOOH translocated from mitochondrial matrix to cytosol
(Homo sapiens)
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG
(Homo sapiens)
Participates
as an event of
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Event Information
Go Biological Process
folic acid metabolic process (0046655)
Orthologous Events
Metabolism of folate and pterines (Bos taurus)
Metabolism of folate and pterines (Caenorhabditis elegans)
Metabolism of folate and pterines (Canis familiaris)
Metabolism of folate and pterines (Danio rerio)
Metabolism of folate and pterines (Dictyostelium discoideum)
Metabolism of folate and pterines (Drosophila melanogaster)
Metabolism of folate and pterines (Gallus gallus)
Metabolism of folate and pterines (Mus musculus)
Metabolism of folate and pterines (Plasmodium falciparum)
Metabolism of folate and pterines (Rattus norvegicus)
Metabolism of folate and pterines (Saccharomyces cerevisiae)
Metabolism of folate and pterines (Schizosaccharomyces pombe)
Metabolism of folate and pterines (Sus scrofa)
Metabolism of folate and pterines (Xenopus tropicalis)
Created
Jassal, B (2007-04-24)
© 2025
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