MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF

Stable Identifier
R-HSA-6801328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF
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Mammalian mitochondria are able to produce formate from one-carbon (1C) donors such as serine, glycine and sarcosine. In mitochondria, the 1C units are oxidised to formate and transported to the cytosol, where the formate is reattached to tetrahydrofolate (THF) for use in de novo purine biosynthesis. The mitochondrial bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolases D2 and D2L (MTHFD2, MTHFD2L) mediate reversible reactions to convert 5,10-methylene-THF, via 5,10-methenyl-THF, to 10-formyl-THF. These enzymes have filled in missing gaps which existed in the transformation of 5,10-methylene-THF to formate in human mitochondria (Yang & MacKenzie 1993, Bolusani et al. 2011, Shin et al. 2014).
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Catalyst Activity

methenyltetrahydrofolate cyclohydrolase activity of MTHFD2, D2L [mitochondrial matrix]

Physical Entity
MTHFD2, D2L [mitochondrial matrix] (Homo sapiens)
Activity
methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)
Orthologous Events
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Bos taurus)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Canis familiaris)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Danio rerio)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Dictyostelium discoideum)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Drosophila melanogaster)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Gallus gallus)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Mus musculus)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Plasmodium falciparum)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Rattus norvegicus)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Saccharomyces cerevisiae)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Schizosaccharomyces pombe)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Sus scrofa)
MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Xenopus tropicalis)
Authored
Jassal, B  (2015-10-01)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-10-01)
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