Reactome | FOLR2 transports FOLA from extracellular region to cytosol

FOLR2 transports FOLA from extracellular region to cytosol

Stable Identifier

R-HSA-8942344

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

ReviewStatus

5/5

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FOLR2 transports FOLA from extracellular region to cytosol

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The folate receptor beta (FOLR2, FBP) binds folate (FOLA) and reduced folic acid derivatives and mediates their delivery into cells (Antony et al. 1985). After ligand binding, the resultant complex is endocytosed into the cell where ligand release occurs in the acidic environment of the recycling endosome (Wibowo et al. 2013). For simplicity, the overall transport of FOLA from the extracellular region to the cytosol of a cell is described here.

Literature References

PubMed ID	Title	Journal	Year
4066659	Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells Kolhouse, JF, Antony, AC, Elwood, PC, Kane, MA, Portillo, RM	J. Biol. Chem.	1985
23934049	Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition Singh, M, Ratnam, M, Dann, CE, Meng, W, Wibowo, AS, Reeder, KM, Kovach, AR, Carter, JJ, Zhang, F	Proc. Natl. Acad. Sci. U.S.A.	2013