MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

Stable Identifier
R-HSA-200676
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
ReviewStatus
5/5
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MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG
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Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyleneTHF polyglutamate, NADPH, and H+ to form 5-methylTHF polyglutamate and NADP+. The specificity and importance of this reaction in vivo have been established through the study of patients deficient in the enzyme (Goyette et al. 1995).
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Catalyst Activity

methylenetetrahydrofolate reductase [NAD(P)H] activity of MTHFR dimer [cytosol]

Physical Entity
MTHFR dimer [cytosol] (Homo sapiens)
Activity
methylenetetrahydrofolate reductase [NAD(P)H] activity (GO:0004489)
Orthologous Events
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Gallus gallus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-24)
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