Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyleneTHF polyglutamate, NADPH, and H+ to form 5-methylTHF polyglutamate and NADP+. The specificity and importance of this reaction in vivo have been established through the study of patients deficient in the enzyme (Goyette et al. 1995).
Rosenblatt, DS, Rozen, R, Goyette, P, Frosst, P
methylenetetrahydrofolate reductase (NAD(P)H) activity of MTHFR dimer [cytosol]
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