MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

Stable Identifier
R-HSA-200676
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
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General
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Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyleneTHF polyglutamate, NADPH, and H+ to form 5-methylTHF polyglutamate and NADP+. The specificity and importance of this reaction in vivo have been established through the study of patients deficient in the enzyme (Goyette et al. 1995).

Literature References
Participants
Participates
Catalyst Activity

methylenetetrahydrofolate reductase (NAD(P)H) activity of MTHFR dimer [cytosol]

Orthologous Events
Created
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