5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+

Stable Identifier
R-HSA-200676
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
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Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyleneTHF polyglutamate, NADPH, and H+ to form 5-methylTHF polyglutamate and NADP+. The specificity and importance of this reaction in vivo have been established through the study of patients deficient in the enzyme (Goyette et al. 1995).

Literature References
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Catalyst Activity
Catalyst Activity
Title
methylenetetrahydrofolate reductase (NAD(P)H) activity of 2xMTHFR [cytosol]
Physical Entity
2xMTHFR [cytosol]
Activity
methylenetetrahydrofolate reductase (NAD(P)H) activity (0004489)
Orthologous Events
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Caenorhabditis elegans)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Canis familiaris)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Danio rerio)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Dictyostelium discoideum)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Drosophila melanogaster)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Gallus gallus)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Mus musculus)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Rattus norvegicus)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Saccharomyces cerevisiae)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Schizosaccharomyces pombe)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Sus scrofa)
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+ (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-23)