MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

Stable Identifier
R-HSA-200676
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyleneTHF polyglutamate, NADPH, and H+ to form 5-methylTHF polyglutamate and NADP+. The specificity and importance of this reaction in vivo have been established through the study of patients deficient in the enzyme (Goyette et al. 1995).

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

methylenetetrahydrofolate reductase (NAD(P)H) activity of MTHFR dimer [cytosol]

Physical Entity
MTHFR dimer [cytosol] (Homo sapiens)
Activity
methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)
Orthologous Events
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Bos taurus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Drosophila melanogaster)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Gallus gallus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Rattus norvegicus)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Schizosaccharomyces pombe)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)
MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-24)
Cite Us!