ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

Stable Identifier
R-HSA-6808496
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of cytosolic biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).

Literature References
PubMed ID Title Journal Year
20498374 ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase

Krupenko, NI, Dubard, ME, Strickland, KC, Moxley, KM, Oleinik, NV, Krupenko, SA

J. Biol. Chem. 2010
21238436 Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase

Strickland, KC, Krupenko, NI, Dubard, ME, Hu, CJ, Tsybovsky, Y, Krupenko, SA

Chem. Biol. Interact. 2011
Participants
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Catalyst Activity
Title
aldehyde dehydrogenase (NAD+) activity of ALDH1L1 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
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Created