ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of cytosolic biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).
Krupenko, NI, Dubard, ME, Strickland, KC, Moxley, KM, Oleinik, NV, Krupenko, SA
Strickland, KC, Krupenko, NI, Dubard, ME, Hu, CJ, Tsybovsky, Y, Krupenko, SA
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