Reactome | ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

Stable Identifier

R-HSA-6808496

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

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ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of cytosolic biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20498374	ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase Krupenko, NI, Dubard, ME, Strickland, KC, Moxley, KM, Oleinik, NV, Krupenko, SA	J. Biol. Chem.	2010
21238436	Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase Strickland, KC, Krupenko, NI, Dubard, ME, Hu, CJ, Tsybovsky, Y, Krupenko, SA	Chem. Biol. Interact.	2011