ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of cytosolic biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).
Moxley, KM, Oleinik, NV, Krupenko, SA, Krupenko, NI, Strickland, KC, Dubard, ME
Hu, CJ, Krupenko, SA, Krupenko, NI, Tsybovsky, Y, Strickland, KC, Dubard, ME
aldehyde dehydrogenase (NAD+) activity of ALDH1L1 tetramer [cytosol]
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