Reactome | SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

Stable Identifier

R-HSA-200652

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Extracellular 5-methyltetrahydrofolate import across the plasma membrane

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SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

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SLC19A1 protein, associated with the plasma membrane, mediates the uptake of extracellular 5-methyltetrahydrofolate and other reduced folates (Williams and Flintoff 1995; Ferguson and Flintoff 1999).

Literature References

PubMed ID	Title	Journal	Year
7852378	Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake Flintoff, WF, Williams, FM	J Biol Chem	1995
10347183	Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion Flintoff, WF, Ferguson, PL	J Biol Chem	1999

Participants

Input

5-methyl-THF [extracellular region]

Output

5-methyl-THF [cytosol]

Participates

as an event of

Metabolism of folate and pterines (Homo sapiens)

Catalyst Activity

folic acid transmembrane transporter activity of SLC19A1 [plasma membrane]

Physical Entity

SLC19A1 [plasma membrane] (Homo sapiens)

Activity

folic acid transmembrane transporter activity (GO:0008517)

Orthologous Events

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Gallus gallus)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)

Created

D'Eustachio, P (2007-07-23)

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