Reactome | SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

Stable Identifier

R-HSA-200652

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Extracellular 5-methyltetrahydrofolate import across the plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SLC19A1 protein, associated with the plasma membrane, mediates the uptake of extracellular 5-methyltetrahydrofolate and other reduced folates (Williams and Flintoff 1995; Ferguson and Flintoff 1999).

Literature References

PubMed ID	Title	Journal	Year
7852378	Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake Williams, FM, Flintoff, WF	J Biol Chem	1995
10347183	Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion Ferguson, PL, Flintoff, WF	J Biol Chem	1999

Participants

Input

5-methyl-THF [extracellular region]

Output

5-methyl-THF [cytosol]

Participates

as an event of

Metabolism of folate and pterines (Homo sapiens)

Catalyst Activity

folic acid transmembrane transporter activity of SLC19A1 [plasma membrane]

Physical Entity

SLC19A1 [plasma membrane] (Homo sapiens)

Activity

folic acid transmembrane transporter activity (GO:0008517)

Orthologous Events

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Gallus gallus)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)

Created

D'Eustachio, P (2007-07-24)

© 2025 Reactome

Cite Us!