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HCOOH translocated from mitochondrial matrix to cytosol
Stable Identifier
R-HSA-6803255
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
,
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Metabolism of folate and pterines (Homo sapiens)
HCOOH translocated from mitochondrial matrix to cytosol (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Formate (HCOOH) is transported from the mitochondrial matrix to the cytosol, where it is reattached to tetrahydrofolate (THF). The mechanism of transport is thought to be carrier-mediated but no protein has been discovered yet (Tibbetts & Appling 2010).
Literature References
PubMed ID
Title
Journal
Year
20645850
Compartmentalization of Mammalian folate-mediated one-carbon metabolism
Appling, DR
,
Tibbetts, AS
Annu. Rev. Nutr.
2010
Participants
Input
HCOOH [mitochondrial matrix]
Output
HCOOH [cytosol]
Participates
as an event of
Metabolism of folate and pterines (Homo sapiens)
Cross References
Rhea
29679
Authored
Jassal, B (2015-10-05)
Reviewed
D'Eustachio, P (2016-10-11)
Created
Jassal, B (2015-10-05)
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