Reactome | Cytosolic folate export across the plasma membrane

Cytosolic folate export across the plasma membrane

Stable Identifier

R-HSA-200646

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

SLC46A1 transports FOLA from cytosol to extracellular region

ReviewStatus

5/5

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Cytosolic folate export across the plasma membrane

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SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition (Qiu et al. 2006; Chen et al. 1996). SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition (Chen et al. 1996; Qiu et al. 2006; Umpathy et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17129779	Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption Qiu, A, Jansen, M, Sakaris, A, Min, SH, Chattopadhyay, S, Tsai, E, Sandoval, C, Zhao, R, Akabas, MH, Goldman, ID	Cell	2006
17962486	Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types Umapathy, NS, Gnana-Prakasam, JP, Martin, PM, Mysona, B, Dun, Y, Smith, SB, Ganapathy, V, Prasad, PD	Invest Ophthalmol Vis Sci	2007
8662720	Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene Chen, L, Qi, H, Korenberg, J, Garrow, TA, Choi, YJ, Shane, B	J Biol Chem	1996