SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition (Qiu et al. 2006; Chen et al. 1996).
Jansen, M, Sandoval, C, Akabas, MH, Goldman, ID, Sakaris, A, Tsai, E, Zhao, R, Chattopadhyay, S, Min, SH, Qiu, A
Korenberg, J, Shane, B, Qi, H, Garrow, TA, Choi, YJ, Chen, L
folic acid transmembrane transporter activity of SLC46A1 [plasma membrane]
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