Cytosolic folate export across the plasma membrane

Stable Identifier
R-HSA-200646
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
SLC46A1 transports FOLA from cytosol to extracellular region
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SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition (Qiu et al. 2006; Chen et al. 1996).

Literature References
PubMed ID Title Journal Year
17129779 Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

Jansen, M, Sandoval, C, Akabas, MH, Goldman, ID, Sakaris, A, Tsai, E, Zhao, R, Chattopadhyay, S, Min, SH, Qiu, A

Cell 2006
8662720 Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene

Korenberg, J, Shane, B, Qi, H, Garrow, TA, Choi, YJ, Chen, L

J Biol Chem 1996
Participants
Participates
Event Information
Catalyst Activity

folic acid transmembrane transporter activity of SLC46A1 [plasma membrane]

Orthologous Events
Created
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