Mitochondrial FPGS-1 transforms THF to THFPG

Stable Identifier
R-HSA-200682
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Conversion of mitochondrial THF to THF-polyglutamate
ReviewStatus
5/5
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Mitochondrial FPGS-1 transforms THF to THFPG
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Mitochondrial folylpolyglutamate synthase catalyzes the reaction of THF-glutamate(n), L-glutamate, and ATP to form THF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of THF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest mitochondrial form of THF has six added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, THF that lacks added glutamate residues cannot be retained in the mitochondrial matrix so this reaction is needed for normal THF function under physiological conditions. The mitochondrial and cytosolic forms of folylpolyglutamate synthase are encoded by the same gene - alternative splicing generates mRNA with or without an initial exon encoding a mitochondrial targeting sequence (Garrow et al. 1992; Chen et al. 1996).
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Catalyst Activity

tetrahydrofolylpolyglutamate synthase activity of FPGS-1 [mitochondrial matrix]

Physical Entity
FPGS-1 [mitochondrial matrix] (Homo sapiens)
Activity
tetrahydrofolylpolyglutamate synthase activity (GO:0004326)
Orthologous Events
Mitochondrial FPGS-1 transforms THF to THFPG (Bos taurus)
Mitochondrial FPGS-1 transforms THF to THFPG (Caenorhabditis elegans)
Mitochondrial FPGS-1 transforms THF to THFPG (Canis familiaris)
Mitochondrial FPGS-1 transforms THF to THFPG (Danio rerio)
Mitochondrial FPGS-1 transforms THF to THFPG (Dictyostelium discoideum)
Mitochondrial FPGS-1 transforms THF to THFPG (Drosophila melanogaster)
Mitochondrial FPGS-1 transforms THF to THFPG (Gallus gallus)
Mitochondrial FPGS-1 transforms THF to THFPG (Mus musculus)
Mitochondrial FPGS-1 transforms THF to THFPG (Rattus norvegicus)
Mitochondrial FPGS-1 transforms THF to THFPG (Saccharomyces cerevisiae)
Mitochondrial FPGS-1 transforms THF to THFPG (Schizosaccharomyces pombe)
Mitochondrial FPGS-1 transforms THF to THFPG (Sus scrofa)
Mitochondrial FPGS-1 transforms THF to THFPG (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-24)
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