MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG

Stable Identifier
R-HSA-200661
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Synonyms
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 10-formylTHF polyglutamate to form 5,10-methenylTHF polyglutamate and H2O. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Literature References
Participants
Input
Output
Participates
as an event of
Event Information
Reverse Reaction
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)
Catalyst Activity

methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]

Physical Entity
MTHFD1 dimer [cytosol] (Homo sapiens)
Activity
methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)
Orthologous Events
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-23)
Cite Us!