MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG

Stable Identifier
R-HSA-200661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O
ReviewStatus
5/5
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MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG
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The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 10-formylTHF polyglutamate to form 5,10-methenylTHF polyglutamate and H2O. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

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Catalyst Activity

methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]

Physical Entity
MTHFD1 dimer [cytosol] (Homo sapiens)
Activity
methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)
Orthologous Events
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-24)
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