MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG

Stable Identifier
R-HSA-200661
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O
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The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 10-formylTHF polyglutamate to form 5,10-methenylTHF polyglutamate and H2O. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Participants
Participates
Event Information
Catalyst Activity

methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]

Orthologous Events
Created
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