10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O

Stable Identifier
R-HSA-200661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O
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The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 10-formylTHF polyglutamate to form 5,10-methenylTHF polyglutamate and H2O. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

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Event Information
Reverse Reaction
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
methenyltetrahydrofolate cyclohydrolase activity of 2xMTHFD1 [cytosol]
Physical Entity
2xMTHFD1 [cytosol]
Activity
methenyltetrahydrofolate cyclohydrolase activity (0004477)
Orthologous Events
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Bos taurus)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Caenorhabditis elegans)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Canis familiaris)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Danio rerio)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Dictyostelium discoideum)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Drosophila melanogaster)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Gallus gallus)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Mus musculus)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Rattus norvegicus)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Saccharomyces cerevisiae)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Schizosaccharomyces pombe)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Sus scrofa)
10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-24)